This article presents a retrospective review of data on side effects of drugs containing naphazoline and data on toxicity of the agent when entered the body via different pathways. Most publications on clinical signs of possible naphazoline-associated side effects are lacking thorough analysis of possible causes. Limited data on the pharmacokinetics and pharmacodynamics of the drug led to various complications after its administration. Therefore, further studies on naphazoline content dynamics or products of its biotransformation in biological substrates and determination of half-life of the agent must be conducted. This will allow establishingsafe levels for different exposure pathways and harmful levels of the naphazoline with respect to its material accumulation. It should be noted that scientific publications contain controversial data regarding allergenic potential of the agent. Possible side effects of the drug on the reproductionand development are not revealed. Determination of effects the products containing naphazoline may have on immune and reproductive system is an important part of the research.
ітчизняний гепатопротектор антраль ефективно використовується для лікування гепатитів різного генезу [1-3], атеросклерозу, ішемічної хвороби серця, порушень згортання крови [4], цукрового діабету [5], обструктивної нефропатії, ускладненої інфекційнозапальним процесом, [6] тощо за їх самостійного перебігу і на тлі хронічної патології печінки [4]. Враховуючи фармакологічні ефекти антралю, можна передбачити його подальше активне впровадження у клінічну практику, що сприятиме збільшенню обсягів його виробництва на вітчизняних підприємствах. Відомо, що дія лікарських препаратів за умов промислового виробництва відрізняється від терапевтичного впливу, оскільки їхні дози, тривалість та шляхи надходження можуть змінюватися. Нині випуск антралю здійснюється за відсутності його гігієнічних нормативів в об'єктах довкілля. Сучасні підходи до оцінки токсичності хімічних речовин передбачають проведення біотестування шляхом застосування КУ ЗЬМІНОВ Б.П., МАТ ИСІК С.І., ЗА ЗУЛЯК Т.С., МИК ИТЧАК Т.І.* Львівс ь кий націона л ьн ий медичний універси тет ім. Да н ила Га ли ць ко го, *Інсти тут ек ол огії Карп ат НАН України УДК 614.35:615.244.099 Ключові сло ва: антраль, то ксичність, Daph nia mag na Straus.
Introduction. According to the European legislation and requirements, industrial production of medication shall be provided with well-defined regulations of the quality of such preparation. Material and methods. Cytotoxic action of hepatoprotector Antral on bull sperm was evaluated. Samples of sperm were divided into control and two experimental samples: control one was diluted with phosphate-buffered saline (PSB), which included NaCl - 0.8 g, KСl - 0.02 g, Na2HPO4 - 0.11 g, КH2PO4 - 0.02 g, MgCl2 - 0.01 г, Н2О till 100ml; in the first experimental sample PSB was added with antral in the dose 1/500 LD50 (2.77 mg); in the second - PSB with Antral in the dose 1/100 LD50 (13.87 mg) was added. The survival of spermatozoa was defined until termination of rectilinear forward movement in sperm, which was preserved in temperature of 2-5 °C; respiratory activity was defined (by polarography (ng-atom O/0.1 ml of semen (S) ∙ min) in thermostated sell (temperature of 38.5 °C), with the volume of 1.0 ml with the automatic registration of process flow by potentiometer, the proportion of decrease of which was evaluated in accordance to impacted dose of antral in substrate and restorative activity was defined potentiometrically (mV/0.1ml C ∙ min) using a system of pen microelectrodes that were inserted in thermostated polarographic cell). Results. In the experimental samples of semen in comparison with the control sample the respiratory and restorative activities were reduced; dose 1/500 LD50 to 58.8% and dose 1/100 LD50 to 68.5%; restorative activity - to 66.7% and 54.5% correspondingly. Conclusion. Antral reduces the survival of sperm being irrespective of dose.
The toxicological assessment of diazoline, the first- generation antihistaminic preparation, was carried out together with justification of the hygiene standard for permissible content ( (Tentative Safe Exposure LevelTSEL) of occupational air in production premises. It was found out that according to acute oral toxicity criterion, Diazoline refers to low hazardous substances. In the clinical picture of acute and sub-chronic intoxication, CNS involvement prevails. Diazolin has a weak local irritant effect in case of contact with mucous membranes, shows a strong cumulative activity. In case of intracutaneous sensitization, it influences indicators of the cellular and humoral component of innate and acquired immunity. TSEL of diazoline in occupational air is 1.0 mg/m .
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.