Justification of Diazoline Permissible Levels in Occupational Air in Chemical and Pharmaceutical Industries

Abstract

The toxicological assessment of diazoline, the first- generation antihistaminic preparation, was carried out together with justification of the hygiene standard for permissible content ( (Tentative Safe Exposure LevelTSEL) of occupational air in production premises. It was found out that according to acute oral toxicity criterion, Diazoline refers to low hazardous substances. In the clinical picture of acute and sub-chronic intoxication, CNS involvement prevails. Diazolin has a weak local irritant effect in case of contact with mucous membranes, shows a strong cumulative activity. In case of intracutaneous sensitization, it influences indicators of the cellular and humoral component of innate and acquired immunity. TSEL of diazoline in occupational air is 1.0 mg/m .