Delta-9-Tetrahydrocannabinol (THC) was dissolved in propylene glycol and 25, 50, or 100 mg/kg administereed dialy sc to pregnant Charles River Sprague-Dawley rats on days 6-15 of gestation (presence of sperm considered day 1). Maternal weight gain was depressed, but a significant decrease in fetal weight occurred only in the 50 mg/kg group. No malformations were noted, only some abnormalities consisting of several instances of rudimentary 14th rib and soft or spongy spinal cords.

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Synthetic delta 9-tetrahydrocannabinol (THC) was dissolved in undiluted propylene glycol and administered in daily subcutaneous doses of 15.0, 30.0 or 60.0 mg/kg to pregnant New Zealand white rabbits on days 7--19 of gestation. Maternal food consumption and weight gain were markedly reduced at all dose levels. Embryotoxicity and embryocidal effects were observed in the form of reduced litter weight and number of viable fetuses, respectively, in offspring from pregnant mothers treated with THC. However, on the basis of extensive external, visceral and skeletal examination of all fetuses it may be concluded that THC is not teratogenic in the New Zealand white strain rabbit following subcutaneous administration of doses as high as 60.0 mg/kg/day during the critical period of organogenesis (days 7--19 of gestation). On the other hand, an oral dose of thalidomide (200.0 mg/kg/day), the positive control used in this study, was both embryocidal and teratogenic.

This work describes the fatty acid and glyceride structures of Indian buffalo milk and depot fats. Only three other an4lyses of buffalo milk fat exist in the literature (Bhattacharya & Hilditch, 1931; Heiduschka & Cicekdagi, 1940), in only one of which was an examination made of the glyceride configuration, while no analysis of buffalo depot fat has so far been reported. The work below was therefore undertaken to indicate peculiarities, if any, in the make-up of the fats and general fat metabolism of the buffalo. Finally, data are presented to illustrate some striking peculiarities of Indian animal fats in both fatty acid and glyceride structures. R.M. =Reichert-Meissl value. P.V. =Polenske value. i.v. =iodine value. s.v. saponification value.

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