Incidence of teratological anomalies in control Charles River C-D strain rats☆

Banerjee, B. N.; Durloo, R. S.

doi:10.1016/0300-483x(73)90028-0

Cited by 21 publications

(6 citation statements)

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“…Since fetal hydroureter is a subjective observation and occurs in varying degrees of dilatation, its incidence was analyzed statistically first as a malformation and then as a variation (the data with hydroureter analyzed as a malformation are presented in Table 7). Neither analysis reveale d its incidence to be significantly increase d. The incidence of hydroureter in the rat fetuses from these studies was comparable to the backgrou nd rate observed by Banerjee and Durloo (1973) in more than 2000 control CD rat fetuses and in a related study from this laboratory (Bates et al, 1990).…”

Section: Dose Groups Summed Across Replicatessupporting

confidence: 76%

Developmental Toxicity of Sarin in Rats and Rabbits

LaBorde

Bates²,

Dacre³

et al. 1996

Journal of Toxicology and Environmental Health

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Sarin (Agent GB, isopropyl methylphosphonofluoridate) is an organophosphate cholinesterase inhibitor. Sarin (Type I or Type II) was administered by gavage to CD rats on d 6-15 of gestation at dose levels of 0, 100, 240, or 380 micrograms/kg/d and to New Zealand White (NZW) rabbits on d 6-19 of gestation at dose levels of 0, 5, 10, or 15 micrograms/kg/d. Females were weighed on gestational days (GD) 0, 6-16 for rats and 6-20 for rabbits, and immediately prior to termination (GD 20 for rats and GD 29 for rabbits). All animals were monitored daily for clinical signs of toxicity throughout dosing and until sacrifice. At necropsy, gravid uteri were weighed and examined for the number and status of implants (live, resorbed, or dead). Individual fetal body weight, malformations, and variations (external, visceral, and skeletal) were recorded. Rat and rabbit dams in the high-dose groups exhibited significant signs of maternal toxicity and increased maternal mortality. Examination of gravid uteri revealed no statistical differences among treatment groups in the incidence of resorptions or of dead or malformed fetuses, or in average body weight of live fetuses per litter. These results show no evidence or developmental toxicity in the CD rat or NZW rabbit following exposure to either Type I or Type II sarin during embryonic differentiation and major organogenesis, even at a dose that produced maternal toxicity.

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Section: Dose Groups Summed Across Replicatessupporting

confidence: 76%

Developmental Toxicity of Sarin in Rats and Rabbits

LaBorde

Bates²,

Dacre³

et al. 1996

Journal of Toxicology and Environmental Health

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“…The present study revealed that there were no male rats with low sperm motility or poor sperm number. The incidences of fetal spontaneous malformations were also reasonably low when compared with those in other strain rats (Banerjee and Durloo, 1973;Nakatsuka et al, 1997), although an incidence of supernumerary ribs in the present study was apparently higher than that in the breeder's catalog (CLEA Japan, Inc., 1999).…”

Section: Discussioncontrasting

confidence: 51%

Historical control data on reproductive abilities and incidences of spontaneous fetal malformations in Wistar Hannover GALAS rats

Aoyama¹,

Kikuta²,

Shirasaka³

et al. 2002

Congenital Anomalies

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Wistar Hannover rats, which have recently been introduced into Japan, are expected to be used in reproductive and developmental toxicity studies, yet the accumulation of background data is insufficient. This paper describes our historical data on the reproductive ability of this strain of rat. Three lots of sexually matured females (40 each) were received from CLEA JAPAN, Inc. with males of the same strain (30 or 36 each) and mated. A total of 47 dams were killed on gestation day 20 to examine their fetuses. The remaining 71 pregnant females were allowed to deliver spontaneously and observed for common reproductive parameters. The mating and fertility indices of females were both 99.2%. Overall mean numbers of implants and live fetuses at cesarean sectioning were 12.5 and 11.5, respectively. Fetal resorptions and deaths occurred at an incidence of 8.6%. Morphological examinations of fetuses revealed low incidences of spontaneous malformations (each one case of double aortic arch and absent cervical vertebral arch) and a variety of common variations. The followings are overall means of major reproductive parameters obtained from females with live birth: no. of implants, 12.5; no. of pups delivered, 11.8; viability index of pups at birth, 99.8%; and days of age at sexual maturation (vaginal opening and preputial separation), 30.3 and 42.8, respectively. Our present observations confirmed a minimal deviation among 3 lots of animals in terms of reproductive abilities. These results suggest that this strain of rat can be used in reproductive and developmental toxicity studies, although the sensitivity to toxicants remains to be elucidated.

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“…Its gestation period is short (about 21 day) and has large number of litters. Rats are characterized by their genetic stability and a very low rate of spontaneous malformation [18,19,20,21,22]. The time of the rat copulation is easily determined by vaginal smear examination method.…”

Section: Materials and Methods: I-materialmentioning

confidence: 99%

The effect of Bombyx mori larvae extract in reducing the toxicity of methotrexate in pregnant female albino rats

Ibrahim

Sayed

Ali

et al. 2019

J. Drug Delivery Ther.

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Methotrexate (MTX) is an anticancer agent which is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, cutaneous T cell lymphoma, and lung cancer. Bombyx mori larvae have a huge value as health food especially for cardiac and diabetic patients, bronchial asthma, primary trigeminal neuralgia, vocal nodules and polyps and in the treatment of facial palsy and pain. In the present study meeting occurred under the normal conditions and about 40 pregnant female rats were used. Herein the pregnant females will be divided into five groups; group 1 will be used as negative control received distilled water, group 2 will used as positive control and recived buffer of Bombyx mori larvae extract, group 3 was treated with MTX at the 12th day of gestation (at organogenesis phase), group 4 was treated with Bombyx mori larvae extract at 7th , 9th , 11th ,13th and 15th days of gestation (during the oraganogensis period), & group 5 was injected by MTX the 12th day of gestation as well as bombyx mori larvae extract at 7th ,9th ,11th ,13th &15th days of gestation. Animals of all groups will be sacrificed at 20th day, the end of gestation periods. Then livers of all pregnant rats were removed for examination. The obtained results showed decrease in maternal body weight gain plus increase in the abortion rate and uterine weight in the MTX-treated group. In addition, MTX induced an elevation in the examined liver oxidative stress biomarkers plus myeloperoxidase activity and decrease in reduced glutathione content and catalase activity; in mothers. Histopathological studies of liver tissues showed congestion of central vein of mothers in MTX group showing ballooning degeneration of hepatocytes, perivascular inflammatory cells infiltration and strong deposition of collagen fibers. Noteworthy, Bombyx mori larvae induced marked improvement in injuries associated with MTX administration. Keywords: Methotrexate, Bombyx mori larvae, Pregnant female rats, Hepatotoxicity.

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Incidence of teratological anomalies in control Charles River C-D strain rats☆

Cited by 21 publications

References 1 publication

Developmental Toxicity of Sarin in Rats and Rabbits

Developmental Toxicity of Sarin in Rats and Rabbits

Historical control data on reproductive abilities and incidences of spontaneous fetal malformations in Wistar Hannover GALAS rats

The effect of Bombyx mori larvae extract in reducing the toxicity of methotrexate in pregnant female albino rats

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