The performance of the SE-9000 automated haematology analyser in a laboratory receiving a high number of abnormal specimens from haematological oncology patients was assessed according to formal protocols for the evaluation of blood cell counters. Linearity over a useful working range, precision in clinically important ranges and negligible carry-over were demonstrated in this group of patient samples confirming the results of previous investigators. The comparability of instrument derived differential leucocyte counts from both normal and distributionally abnormal samples with those obtained by visual microscopy using the NCCLS H-20 A protocol was very good. The sensitivity of flags for the detection of immature granulocytes and myeloid blast cells was high and this can be attributed to the incorporation of a new measuring channel (Immature Myeloid Information or IMI channel). The number of unrecognized abnormalities was low and when compared with the poor sensitivity of the routine 100-cell visual differential leucocyte count, the analyser was judged suitable for monitoring patients with haematological malignancies. The performance of flags such as 'left shift' and 'atypical lymphocytes' can be improved by taking into consideration distributional abnormalities such as neutrophilia and lymphocytosis. The trigger level for these flags should be adapted to the clinical need particularly in cases of neutropenia following chemotherapy, and in lymphoproliferative disorders and infection.
Im Rahmen unserer systematischen (S a n t a v f 1957) Untersuchung colcliicinhaltiger Pflanzen (und ihrer Bestandteile) wandten wir von allem Anfang an unsere Aufmerksamkeit auch der Gloriosa superba zu. Aus den Knollen dieser Pflanze (gesammelt in Ceylon) haben bereits im Jahre 1915 C 1 e W e r , G r e e n U. T U t i n neben Colchicin eine Reihe weiterer Substanzen isoliert. Da das Material aus Gebieten, in denen diese Pflanze wild vorkommt, schwer zugänglich ist, haben wir zuerst die in europäischen Gewächshäusern als Zierpflanze gezogenen Knollen untersucht (S a n t a V f U. B a r t e k 1952). Kürzlich hatten wir nun Gelegenheit, Knollen, Blätter und Blüten der Gloriosa indischer Herkunft zu analysieren (PotESilovA, B a r t o Z o * i U. S a n t a v j 1954; S a n t a v f , K i n c l U. S h i n d e 1957). S u b b a r a t n a m (1952, 1953) führte auch unabhängig von uns die Untersuchung der in Indien wachsenden Knollen durch. Die Samen von Gloriosa superba sind bisher überhaupt nicht untersucht worden, und keiner der genannten Autoren analysierte die Knollen der in Afrika wachsenden Gloriosn superba.
Subretinal fluid and serum from 34 patients with retinal detachment were excmined using disc electrophoresis on polyacrylamide gel. A quantitative evaluation of 4 groups of globulin fractions, namely post-albumin (POST) fraction, transferrin (T) fraction, polyglobulin (POLY) fraction and macroglobulin (MACRO) fraction, has been made, and it was found that the fractions POST and T, in comparison to serum, are considerably increased while the fractions POLY and MACRO of subretinal fluid are decreased. There was a significant reduction in POST and an increase in POLY fractions present in cases of retinal detachment more than 3 months old and those affecting large areas of the retina. The level of T fraction was lower in cases when retina failed to become attached after operation.
Aqueous humour and serum taken from 24 patients with retinal detachment have been examined using the technique of disc electrophoresis on polyacrylamide gel. An evaluation of four groups of globulin fractions (post-albumins, transferrin, polyglobulin and macroglobulin) has been made in persentages of the total number of globulins. Significant differences were found in the 4 aqueous humour globulin fractions as compared to the same fractions of the serum. Patients with retinal detachment due to inflammation were characterized by the higher level of the post-albumin fraction and lower level of the transferrin fraction in the aqueous humour, whereas in traumatic cases and in aphakia the conditions were just the opposite. With the duration of the disease, the level of the polyglobulin fraction was enhanced both in the aqueous humour and in the serum.
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