RS-8359, (+/-)-4-(4-cyanoanilino)-5,6-dihydro-7-hydroxy-7H-cyclopenta[d]pyrimidine selectively and reversibly inhibits monoamine oxidase A (MAO-A). After oral administration of rac-RS-8359 to rats, mice, dogs, monkeys, and humans, plasma concentrations of the (R)-enantiomer were greatly higher than were those of the (S)-enantiomer in all species studied. The AUC((R)) to AUC((S)) ratios were 2.6 in rats, 3.8 in mice, 31 in dogs, and 238 in monkeys, and the (S)-enantiomer was almost negligible in human plasma. After intravenous administration of RS-8359 enantiomers to rats, the pharmacokinetic parameters showed that the (S)-enantiomer had a 2.7-fold greater total clearance (CL(t)) and a 70% shorter half-life (t(1/2)) than those for the (R)-enantiomer but had no difference in distribution volume (V(d)). No significant difference in the intestinal absorption rate was observed. The principal metabolites were the 2-keto form, possibly produced by aldehyde oxidase, the cis-diol form, and the 2-keto-cis-diol form produced by cytochrome P450 in rats, the cis-diol form in mice, RS-8359 glucuronide in dogs, and the 2-keto form in monkeys and humans. Thus, the rapid disappearance of the (S)-enantiomer from the plasma was thought to be due to the rapid metabolism of the (S)-enantiomer by different drug-metabolizing enzymes, depending on species.

The binding of (؊)-epigallocatechin gallate (EGCG), a representative natural polyphenol, to human serum albumin (HSA) and bovine serum albumin (BSA) was investigated using induced circular dichroism (

second indoor sample (collected at a spectator's area) was 221 ppb, with a range of 1-3,175 ppb. The ratio of the indoor to outdoor NO 2 concentrations was above 1 for 95% of the rinks sampled, indicating the presence of an indoor NO 2 source (mean indoor:outdoor ratio = 20). Estimates of short-term NO 2 concentrations indicated that as many as 40% of the sampled rinks would have exceeded the World Health Organization 1-hour guideline value of 213 ppb NO 2 for indoor air.Statistically significant associations were observed between NO 2 levels and the type of fuel used to power the resurfacer, ABSTRACTAn international survey of nitrogen dioxide (NO 2 ) levels inside indoor ice skating facilities was conducted. One-week average NO 2 concentrations were measured inside and outside of 332 ice rinks located in nine countries. Each rink manager also completed a questionnaire describing the building, the resurfacing machines, and their use patterns. The (arithmetic) mean NO 2 level for all rinks in the study was 228 ppb, with a range of 1-2,680 ppb, based on a sample collected at breathing height and adjacent to the ice surface. The mean of the Brauer, Lee, Spengler, Salonen, Pennanen, Braathen, Mihalikova, Miskovic, Nozaki, Tsuzuki, Rui-Jin, Xu, Qing-Xiang, Drahonovska, and Kjaergaard Journal of the Air & Waste Management AssociationVolume 47 October 1997 the absence of a catalytic converter on a resurfacer, and the use of an ice edger. There were also indications that decreased use of mechanical ventilation, increased number of resurfacing operations per day, and smaller rink volumes were associated with increased NO 2 levels. In rinks where the main resurfacer was powered by propane, the NO 2 concentrations were higher than in those with gasoline-powered resurfacers, while the latter had NO 2 concentrations higher than in those using diesel. Rinks where the main resurfacer was electric had the lowest indoor NO 2 concentrations, similar to the levels measured outdoors.

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QEESI # (Miller and Prihoda, 1999a: Toxicology and Industrial Health , 15, 370) was applied to 498 subjects, recruited from the general population of Miyagi prefecture, Japan, who had not been diagnosed previously as having multiple chemical sensitivity (MCS) or sick building syndrome.Seventeen (3.8%) of 440 subjects who returned valid completed questionnaires were classified as having symptoms 'very suggestive' of MCS using the four-classification system of Miller and Prihoda (1999a). We conducted detailed telephone interviews with these 17 individuals. All were visiting local hospitals on an outpatient basis with diagnoses other than MCS and had either current or previous presumed chemical exposure. Therefore, we recommended they undergo a medical check by MCS medical experts and indoor air quality assessment.Seven subjects participated in both the medical check and indoor air quality monitoring, six subjects participated in indoor air quality monitoring only and four subjects participated in neither. The seven subjects who participated in both the medical check and monitoring were diagnosed as having MCS by the above expert physicians. In nine houses of 13 subjects who participated in indoor environmental quality (IEQ) survey, acetaldehyde (9/9), formaldehyde (8/9), total volatile compounds (TVOCs) (6/9) and paradichlorobenzene (3/9) levels were above the respective guideline values for indoor air concentrations, outlined by the Ministry of Health, Labor and Welfare of Japan and were presumed to act as factors contributing to the subjects' hypersensitivity and onset or development of symptoms.These results suggested that there might still be a population of patients not properly diagnosed as having MCS by clinicians in Japan. Therefore, we verified the efficacy of QEESI (Japanese version) for screening of MCS patients.The results of indoor air quality analysis suggested the manifestation and deterioration of MCS in Japan might be precipitated by indoor air pollutants, such as formaldehyde, acetaldehyde, volatile compounds (VOCs) and paradichlorobenzene. Toxicology and Industrial Health 2005; 21: 113 Á/124.

In order to make clear the relationship the chemical substances concentration and symptom of sick house syndrome, an investigation of 62 houses in Japan has been done for 9 years. The results showed that the indoor air of many sick houses was polluted with high carbonyl compounds and Volatile Organic Compounds (VOC) concentrations exceeded the criterions of Japan Standard. In addition, high concentration was found not only in the houses which were just built or renovated, but also in the houses with well-air-tightened and low air change rate.Keywords : Sick House Syndrome, Field survey, VOC, Formaldehyde, Occupant's health, Statistician In order to make clear the relationship between the chemical substances concentration and symptom of sick house syndrome, an investigation of 62 houses in Japan has been done for 9 years. The results showed that the indoor air of many sick houses was polluted with high carbonyl compounds and Volatile Organic Compounds (VOC) concentrations exceeded the criterions of JapanStandard. In addition, high concentration was found not only in the houses which were just built or renovated, but also in the houses with well-air-tightened and low air change rate.

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