Alkane diols from flower petals of Carthamus tinctorius

Akihisa, Toshihiro; Nozaki, Atsuo; Inoue, Youhei; Yasukawa, Ken; Kasahara, Yoshiyuki; Motohashi, Shigeyasu; Kumaki, Kunio; Tokutake, Norio; Takido, Michio; Tamura, Toshitake

doi:10.1016/s0031-9422(97)00067-8

Cited by 22 publications

(15 citation statements)

References 5 publications

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“…is a commonly used traditional Chinese medicine for treatment of cardiovascular diseases [19], in which components with a wide range of polarity coexist, such as flavonoids [20], polyacetylenes [21], serotonin derivatives [22], steroids [23], lignans [24,25] and alkane diols [26,27], etc. In our former report [28], its medium-polarity component was analyzed by 2D-RPLC/HILIC system based on C18 and click b-CD columns, and the result demonstrated the great complexity of the sample.…”

Section: Discussionmentioning

confidence: 99%

Development of orthogonal two‐dimensional hydrophilic interaction chromatography systems with the introduction of novel stationary phases

Liu

Guo

Feng

et al. 2009

J of Separation Science

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Two different offline 2-D hydrophilic interaction chromatography (2D-HILIC/HILIC) systems have been developed. In the two systems, a click maltose column was used in the first dimension, an amide column or a click beta-CD column was used in the second dimension, respectively. Both of the systems were used for the analysis of very polar components in Carthamus tinctorius Linn., which is a traditional Chinese medicine. Excellent orthogonality and separation results were obtained in both 2D-HILIC/HILIC systems, while the peak capacity of the system based on click maltose and amide column was higher for its adoption of stationary phase with smaller particle size in the second dimension.

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Section: Discussionmentioning

confidence: 99%

Development of orthogonal two‐dimensional hydrophilic interaction chromatography systems with the introduction of novel stationary phases

Liu

Guo

Feng

et al. 2009

J of Separation Science

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“…The active agents, stigmasterol and other phytosterols were isolated from the active fraction of safflower, and stigmasterol inhibited tumor promotion by DMBA/TPA in mouse skin . Subsequently, alkane-6,8-diols were isolated from other active safflower fractions (Akihisa, et al, , 1997. Alkanediol from safflower and synthetic C29-alkane-6,8-diol inhibited tumor promotion by DMBA/TPA in mouse skin (Motohashi, et al, 1995;Yasukawa, et al, 1996b).…”

Section: Compositae Plants and Their Active Componentsmentioning

confidence: 99%

Medicinal and Edible Plants as Cancer Preventive Agents

Yasukawa¹

2012

Drug Discovery Research in Pharmacognosy

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“…The chemical constituents from this plant have been examined, and the isolation of flavonoids [2,3], polyacetylenes [4], serotonin derivatives [5], steroids [6], lignans [7,8], alkanediols [9,10] have been reported. The chalcones in Carthamus tinctorius L. are biologically active compounds, which are reported to have anti-inflammatory, antioxidant, antihepatotoxic, antiviral activities, vasculo-protector and spasmolytic properties [11].…”

Section: Introductionmentioning

confidence: 99%

Separation and determination of chalcones fromCarthamus tinctorius L. and its medicinal preparation by capillary zone electrophoresis

Jiang

Wang

2005

J. Sep. Science

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A new capillary zone electrophoresis (CZE) method was developed for simultaneous assay of four chalcones, hydroxysafflor yellow A, safflor yellow A, safflamin C, and safflamin A, in the Chinese herbal extract from Carthamus tinctorius L. The optimum buffer system was 30 mM borate buffer (Na2B407/HCl, pH 9.00) with 10% (v/v) methanol. The voltage was 15 kV and detection was at 270 nm. Regression equations revealed linear relationships (correlation coefficients: 0.9973, 0.9992, 0.9989, and 0.9996) between the peak area of each compound and its concentration. The within-day relative standard deviations of migration times and peak areas were < 1.53 and 4.14%, respectively. The effects of several CE parameters on the resolution were studied systematically. The contents of four chalcones in Carthamus tinctorius L. were successfully determined with satisfactory repeatability and recovery. The possibilities of using this method for the determination of chalcones in Chinese medicinal preparation was also tested.

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Alkane diols from flower petals of Carthamus tinctorius

Cited by 22 publications

References 5 publications

Development of orthogonal two‐dimensional hydrophilic interaction chromatography systems with the introduction of novel stationary phases

Development of orthogonal two‐dimensional hydrophilic interaction chromatography systems with the introduction of novel stationary phases

Medicinal and Edible Plants as Cancer Preventive Agents

Separation and determination of chalcones fromCarthamus tinctorius L. and its medicinal preparation by capillary zone electrophoresis

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