Interaction of Polyphenolic Metabolites with Human Serum Albumin: A Circular Dichroism Study

Nozaki, Atsuo; Kimura, Takeshi; Ito, Hideyuki; Hatano, Tsutomu

doi:10.1248/cpb.57.1019

Cited by 28 publications

(11 citation statements)

References 19 publications

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Section: Effects Of Catabolitesmentioning

confidence: 99%

“…3 -Hydroxyphenylpropionic acid, 3 ,4 -dihydroxyphenylpropionic and 3 -methoxy-4 -hydroxyphenylpropionic might also achieve sufficient concentrations following repeated consumption of coffee or tea. Note, however, that at least some of these catabolites, including protocatechuic and vanillic acids, bind to human serum albumin [172], and this might reduce their potency in vivo.There has been limited investigation of mixtures of (poly)phenolic catabolites. In one study there was no evidence of any additive effect [173], but in another study a mixture of 4-hydroxybenzoic acid, protocatechuic acid and vanillic acid (albeit each at 0.33 µM) was more effective than any component alone at the same concentration [174], suggesting that there is some synergy rather than merely an additive effect.…”

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Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Williamson

Clifford

2017

Biochemical Pharmacology

265

172

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Please cite this article as: G. Williamson, M.N. Clifford, Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols, Biochemical Pharmacology (2017), doi: http://dx.doi.org/10.1016/ j. bcp.2017.03.012 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1Role of the small intestine, colon and microbiota in determining the metabolic fate of in the small intestine, or reaches the colon and is subject to extensive catabolism by colonic microbiota. Untransformed substrates may be absorbed, appearing in plasma primarily as methylated, sulfated and glucuronidated derivatives, with in some cases the unchanged substrate. Many of the catabolites are well absorbed from the colon and appear in the plasma either similarly conjugated, or as glycine conjugates, or in some cases unchanged.Although many (poly)phenol catabolites have been identified in human plasma and / or urine, the pathways from substrate to final catabolite, and the species of bacteria and enzymes involved, are still scarcely reported. While it is clear that the composition of the human gut microbiota can be modulated in vivo by supplementation with some (poly)phenol-rich commodities, such modulation is definitely not an inevitable consequence of supplementation, it depends on the treatment, length of time and on the individual metabotype, and it is not clear whether the modulation is sustained when supplementation ceases. Some catabolites have been recorded in plasma of volunteers at concentrations similar to those shown to be effective in in vitro studies suggesting that some benefit may be achieved in vivo by diets yielding such catabolites. and are also present at high levels in supplements [4], and form essential components of many Chinese medicines [5]. A study within the European Prospective Investigation intoCancer and Nutrition (EPIC) using the Phenol Explorer database reported that the cohort studied consumed 427 different polyphenols including 94 that were consumed at a rate of >1 g/day. The estimated total polyphenol consumption ranged from 584 mg/day by Greek women to 1786 mg/day for men in Aarhus-Denmark. The corresponding data for Greek men and for Aarhus women were 744 mg/day and 1626 mg/ day, respectively, with all data adjusted for age and weighted by season and weekday of dietary recall [6]. This study defined the major contributors to be the phenolic acids (predominantly the caffeoylquinic acids (27-53%), also called chlorogenic acids) and flavonoids (predominantly flavanols (16-29%), proanthocyanidins (5-9%) and theaflavins (14-25%)) [6]. Hydroxybenzoic acids (3.3-7.4%), alkyl-phenols (1.6...

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Section: Effects Of Catabolitesmentioning

confidence: 99%

mentioning

confidence: 99%

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Williamson

Clifford

2017

Biochemical Pharmacology

265

172

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“…Indeed, they have been shown to induce antitumor, antibacterial, antimutagenic and anticancerogenic effects (Kroll, Rawel, & Rohn, 2003), although many studies have also demonstrated their harmful effects, especially when applied at high concentrations (Arts, Hollman, de Mesquita, Feskens, & Kromhout, 2001;Lambert, Sang, & Yang, 2007). These properties are partially attributed to the interactions between the polyphenols and biomolecules in the body, such as proteins and lipids (Ishii et al, 2009;Nozaki, Kimura, Ito, & Hatano, 2009). …”

Section: Introductionmentioning

confidence: 99%

Interactions of different polyphenols with bovine serum albumin using fluorescence quenching and molecular docking

et al. 2012

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“…9). Our investigation of the binding of EGCG and those low-molecular-weight metabolites revealed that they affects the bindings of site-I-and site-II-binding drugs to human serum albumin, depending on their structures (Nozaki et al, 2009). …”

Section: State In Hot-water Extract: Possible Binding To Other Compoundsmentioning

confidence: 89%

Functional Analysis of Natural Polyphenols and Saponins as Alternative Medicines

Sakagami¹,

Kushida²,

Makino³

et al. 2012

A Compendium of Essays on Alternative Therapy

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Interaction of Polyphenolic Metabolites with Human Serum Albumin: A Circular Dichroism Study

Cited by 28 publications

References 19 publications

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Interactions of different polyphenols with bovine serum albumin using fluorescence quenching and molecular docking

Functional Analysis of Natural Polyphenols and Saponins as Alternative Medicines

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