Several studies have shown that individuals with previous history of SARS-CoV-2 infection had boosted antibody response after single dose of mRNA or adenovirus-vectored vaccines. We wondered whether single dose CoronaVac, a whole-inactivated vaccine, could be considered for COVID-19 survivors in Indonesia. We measured IgG anti-RBD titre among 18 survivors and 37 non-survivors. Among survivors, there were 9 survivors with positive antibody titre (seropositive) before vaccination and 9 seronegative survivors. All respondents received two doses of CoronaVac vaccine at 14-days interval. We found no significant antibody titre difference between non-survivor at 14 or 28 days after second dose as well as seronegative survivor at at 14 days after second dose. Seropositive survivors were rapidly boosted after first dose with higher antibody titer than non-survivors and seronegative survivors after second dose. However, antibody titer did not differ between first and second dose among seropositive survivors. Seropositive COVID-19 survivors could receive single dose of CoronaVac vaccine which could potentially ease the vaccine supply constrain. A long-term follow-up must be conducted to observe difference in antibody response and persistence.
Maternal Mortality Rate (MMR) is an indicator to assess the degree of a nation, especially women. MMR according to the results of the 2012 Indonesian Demographic and Health Survey in Indonesia was 359 per 100,000 live births. The most common causes of maternal death in the city of Dumai are ante partum hemorrhage and preeclampsia in 3 cases each. The purpose of this service activity is to increase knowledge and understanding of anemia in pregnant women and to find out the status of anemia in pregnant women at the Sungai Sembilan Health Center, Sungai Sembilan District, Dumai Regency. In addition to counseling activities, a pre-test and post-test were carried out using 10 multiple-choice questions to assess the knowledge of the community, totaling 30 people. Overall, more than 50% of participants already have a good level of knowledge about anemia in pregnancy. There were 33% of participants who had a hemoglobin level <11 which means they had mild anemia. By conducting counseling about anemia and hemoglobin examination, it is hoped that it can increase the knowledge of the community at the Sungai Sembilan Health Center, Sungai Sembilan District, Dumai Regency.
Stunting merupakan kondisi malnutrisi kronis pada anak yang ditandai dengan tinggi badan anak berada di bawah 2 standar deviasi dibawah grafik pertumbuhan anak. Stunting menjadi masalah kesehatan yang serius terutama di negara-negara berkembang, termasuk di Indonesia. Kampar merupakan salah satu wilayah prioritas penanganan stunting di Provinsi Riau dengan 10 lokus stunting yang telah diidentifikasi. Desa Tambang Kecamatan Tambang merupakan desa di Kabupaten Kampar dengan prevalensi stunting cukup tinggi yaitu memiliki 42 balita. Tujuan dari kegiatan pengabdian ini adalah meningkatkan pengetahuan dan keterampilan kader Desa Tambang dalam melakukan penilaian status gizi anak balita. Pengabdian dilakukan pada bulan Juli 2020 di Kantor Camat Tambang. Metode pelatihan meliputi ceramah, tanya jawab, studi kasus dan praktek langsung pengukuran tinggi dan berat badan anak balita. Topik pelatihan meliputi stunting dan strategi pencegahan stunting di desa, penilaian status gizi anak balita serta kebutuhan gizi ibu hamil dan anak balita. Pelatihan diikuti oleh 25 kader posyandu yang ada di Desa Tambang. Hasil evaluasi kegiatan menggunakan kuesioner pre-test dan post-test menunjukkan terdapat peningkatan pengetahuan kader posyandu tentang stunting dan strategi pencegahannya.
Salah satu kendala program vaksinasi dalam penanganan pandemiCorona Virus Disease 19 (COVID-19) adalah stok vaksin yang terbatas. Beberapa studi pada vaksin mRNA menunjukkan bahwa penyintas COVID-19 menunjukkan respon yang lebih cepat dalam membentuk antibodi. Penelitian ini bertujuan memberikan gambaran awal mengenai respon imun penyintas COVID-19 setelah pemberian vaksin CoronaVac. Metode: 14 sampel dari penyintas COVID-19 yang divaksinasi menggunakan CoronaVac diambil untuk melihat total antibodi terhadap Receptor Binding Domain (RBD) protein spike SARS-CoV-2 yang diperiksa dari serum pada sebelum vaksinasi, 14 hari setelah dosis pertama, dan 14 hari setelah dosis kedua. Hasil: Didapatkan 6 orang penyintas mempunyai antibodi anti RBD (seropositif) sedangkan 8 orang lainnya tidak (seronegatif). Rerata durasi PCR positif menunjukkan individu seronegatif memiliki waktu yang lebih singkat (3,3 ± 1,7 hari, p<0.001) dibandingkan kelompok seropositif Kesimpulan: Kelompok penyintas seropositif mengalami peningkatan antibodi yang signifikan setelah pemberian vaksin dosis pertama (GMT 648.6,166.0 U/mL). Titer ini signifikan lebih tinggi jika dibandingkan dengan kelompok seronegatif bahkan setelah pemberian vaksin dosis kedua (GMT 49.1, 95% CI 14.0 -172.7 U/mL). Temuan awal ini harus direplikasi dalam sampel yang lebih besar untuk mengidentifikasi prioritas vaksinasi diantara individu yang sebelumnya terinfeksi.
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