Abstract.A neurodegenerative accumulation of α-synuclein effect of rotenone on the increase synuclein in the midbrain of Wistar rats. Thirty 250 g) were divided into three groups: the Blank group, the Solvent group (intraperitoneally injected with 1 ml/kg body weight of sunflower seed oil), and the Rotenone group (intraperitoneally injected with 2.5 mg/kg body weight of rotenone) for 9, 19, and 28 days. The rats were for the 9-day treatment, day 20 for the 19 for the 28-day treatment (2 rats/gr midbrains were isolated and extracted. Glutathione assay and α tests were performed. The results showed that the average oxidative stress index was highest in the Blank group (0.95 ± 0.24, 0.63 ± respectively). Meanwhile, groups (0.09 ± 0.03, 0.15 ± 0.03, and 0.13 ± 0.02 ng/mg tissue, respectively). Correlation analysis showed that the oxidative stress index proportional to the concentration of α midbrain of Wistar rats treated with rotenone indicated oxidative stress and led to an accumulation of α-synuclein protein. Here, we report our findings on the on the increase of oxidative stress and accumulation of α-synuclein in the midbrain of Wistar rats. Thirty six male rats (8-9 weeks, 200-were divided into three groups: the Blank group, the Solvent-rotenone group (intraperitoneally injected with 1 ml/kg body weight of sunflower seed tenone group (intraperitoneally injected with 2.5 mg/kg body weight of rotenone) for 9, 19, and 28 days. The rats were decapitated on day 10 day treatment, day 20 for the 19-day treatment, day 30, 40, 50 and 60 day treatment (2 rats/group or 6 rats/day of observation time). The midbrains were isolated and extracted. Glutathione assay and α-synuclein ELISA tests were performed. The results showed that the average oxidative stress index was highest in the Blank group (0.95 ± 0.24, 0.63 ± 0.23, 0.81 ± 0.27, Meanwhile, the concentration of α-Synuclein had decreased in all (0.09 ± 0.03, 0.15 ± 0.03, and 0.13 ± 0.02 ng/mg tissue, respectively). Correlation analysis showed that the oxidative stress index was inversely ortional to the concentration of α-synuclein. Our conclusion is that the midbrain of Wistar rats treated with rotenone indicated oxidative stress and led synuclein protein. Keyword
Abstract. Land use in the Cikapundung watershed by constructing buildings at a distance of less than 10 meters from the river causes an increase in the burden of river water pollution by domestic waste. Not least in the Tamansari Village, only a few of the heads of families have access to clean water, so they still use well water that is close to the Cikapundung River and has the potential to be polluted due to domestic waste disposal, one of the contaminants is Escherichia coli bacteria. This study aims to analyze Escherichia coli contamination in water sources along the Cikapundung River in Tamansari Village. The samples taken were 10 wells along the Cikapundung River in Tamansari Village. This study uses a descriptive observational method. The results showed that the Escherichia coli content in 10 wells taken along the Cikapundung River, Tamansari Village, exceeded the quality standards set in accordance with Minister of Health Regulation No. 492 of 2010, namely 0 CFU/100ml of water sample. Two out of 10 wells had Escherichia coli content of 4 CFU/100ml water sample, while 8 out of 10 wells had Escherichia coli content of >2400 CFU/100ml water sample. All water samples examined did not meet the quality standards set by the Minister of Health Regulation No. 492 of 2010, well water along the Cikapundung River, Tamansari Village has polluted water quality. Theoretically, watersheds are not allowed to have land or building structures that stand less than 10 meters, so it needs attention from local regional policy makers, one of the consequences is polluting the water sources used by local residents. Abstrak. Penggunaan lahan di DAS Cikapundung dengan mendirikan bangunan pada jarak kurang dari 10 meter dari sungai menyebabkan peningkatan beban pencemaran air sungai oleh limbah domestik. Tak terkecuali di Kelurahan Tamansari terhitung hanya sedikit dari sejumlah kepala keluarga yang mendapatkan akses air bersih sehingga masih memanfaatkan air sumur yang dekat dengan Sungai Cikapundung serta berpotensi tercemar karena pembuangan limbah domestik, salah satu pencemarnya adalah bakteri Escherichia coli. Penelitian ini bertujuan untuk menganalisis cemaran Escherichia coli pada sumber air di sepanjang Sungai Cikapundung di Kelurahan Tamansari. Sampel yang diambil adalah air sumur di sepanjang Sungai Cikapundung di Kelurahan Tamansari sejumlah 10 sumur. Penelitian ini menggunakan metode observasional deskriptif. Hasil penelitian menunjukkan bahwa kandungan Escherichia coli pada 10 sumur yang diambil di sepanjang Sungai Cikapundung Kelurahan Tamansari melebihi baku mutu yang ditetapkan sesuai dengan Peraturan Menteri Kesehatan No. 492 Tahun 2010 yaitu 0 CFU/100ml sampel air. Dua dari 10 sumur memiliki kandungan Escherichia coli sebanyak 4 CFU/100ml sampel air, sementara 8 dari 10 sumur memiliki kandungan Escherichia coli sebanyak >2400 CFU/100ml sampel air. Semua sampel air yang diperiksa tidak memenuhi baku mutu yang ditetapkan sesuai dengan Peraturan Menteri Kesehatan No. 492 Tahun 2010, air sumur di sepanjang Sungai Cikapundung Kelurahan Tamansari memiliki kualitas air tercemar. Secara teoritis daerah aliran sungai tidak diperbolehkan terdapat adanya lahan atau struktur bangunan yang berdiri kurang dari 10 meter sehingga perlu adanya perhatian dari pemangku kebijakan daerah setempat, salah satu akibatnya adalah mencemari sumber air yang dimanfaatkan warga sekitar.
Abstract. Poor sleep quality can reduce cognitive function, which has a negative effect on academic performance. Physical activity is one of the factors that affect sleep quality, because low physical activity causes a decrease in sleep quality, but there is no clear mechanism for the relationship between the two. This study aims to analyze the relationship between physical activity and sleep quality in students of the Faculty of Medicine, Islamic University of Bandung. This research is quantitative observational analytic with a cross sectional research design. Data analysis used purposive sampling technique, then data was analyzed using Chi-Square. The subjects of this study amounted to 100 respondents. Data were collected using the International Physical Activity Questionnaire and Pittsburgh Sleep Quality Index questionnaires. The results showed that 48% of students had low physical activity and 40% of them had poor sleep quality. Based on this study, it was concluded that there was no relationship between physical activity and sleep quality in students of the Faculty of Medicine, Islamic University of Bandung after Chi-Square analysis (p> 0.05). This can be caused by other factors such as psychological conditions, lifestyle, and physical health that affect sleep quality. Abstrak. Kualitas tidur buruk dapat menurunkan fungsi kognitif yang memberikan efek negatif terhadap performa akademik. Aktivitas fisik menjadi salah satu faktor yang memengaruhi kualitas tidur sebab aktivitas fisik yang rendah menyebabkan penurunan kualitas tidur, namun belum diperoleh mekanisme hubungan yang jelas diantara keduanya. Penelitian ini bertujuan untuk menganalisis hubungan antara aktivitas fisik dengan kualitas tidur pada mahasiswa Fakultas Kedokteran Universitas Islam Bandung. Penelitian ini merupakan kuantitatif analitik observasional dengan desain penelitian cross sectional. Analisis data menggunakan teknik purposive sampling, selanjutnya data dianalisis menggunakan Chi-Square. Subjek penelitian ini berjumlah 100 responden. Data diambil dengan metode kuesioner International Physical Activity Questionnaire dan Pittsburgh Sleep Quality Index. Hasil penelitian menunjukkan bahwa sebanyak 48% mahasiswa memiliki aktivitas fisik rendah serta 40% diantaranya memiliki kualitas tidur buruk. Berdasarkan penelitian ini, diperoleh simpulan bahwa tidak terdapat hubungan antara aktivitas fisik dengan kualitas tidur pada mahasiswa Fakultas Kedokteran Universitas Islam Bandung setelah dilakukan analisis Chi-Square (p>0,05). Hal tersebut dapat disebabkan oleh faktor lain seperti kondisi psikologis, gaya hidup, dan kesehatan fisik yang memengaruhi kualitas tidur. Kata Kunci: Aktivitas fisik, Kualitas tidur, Mahasiswa kedokteran
Abstract. The high incidence of dyslipidemia is one of the risk factors for cardiovascular disease in Indonesia, therefore optimal treatment is needed, but pharmacological therapy has many side effects. Hesperidin herbal treatment with minimal side effects can be considered as complementary therapy. The purpose of this study was to analyze the effect of hesperidin on lipid levels of dyslipidemic rats. This study uses a scoping review method using four databases (Springerlink, Sciencedirect, Pubmed, Proquest) with articles from 2011 – 2021 which with certain keywords obtained 680 articles, then after screening using PICOS four articles were obtained. There are four articles that meet the eligible criteria according to the critical appraisal instrument Arrive 2.0. The research design of the article is entirely true experimental with a population of dyslipidemic rats given hesperidin. The results of all articles showed a decrease in lipid levels (decrease in TC, TG, C-LDL, and increased C-HDL) significantly (p < 0.05). The processes involved in improving the lipid profile in this study were the inhibition of HMG-CoA reductase, ACAT, and regulation of mRNA, C-FABP, and H-FABP that play a role in fat metabolism. Thus, hesperidin can reduce lipid levels in dyslipidemic rats, but this study is qualitative, furthermore it is recommended for further researchers to conduct studies using quantitative methods (meta analysis). Abstrak. Tingginya angka kejadiaan dislipidemia merupakan salah satu faktor risiko dari penyakit kardiovaskular di Indonesia, maka penanganan optimal sangat dibutuhkan, namun terapi farmakologis memiliki banyak efek samping. Pengobatan herbal hesperidin yang minim efek samping dapat dipertimbangkan sebagai terapi komplementer. Tujuan penelitian ini adalah untuk menganalisis efek hesperidin pada kadar lipid tikus dislipidemia. Penelitian ini menggunakan metode scoping review menggunakan empat database (Springerlink, Sciencedirect, Pubmed, Proquest) dengan artikel dari tahun 2011 – 2021 yang dengan kata kunci tertentu didapat 680 artikel, kemudian setelah dilakukan screening menggunakan PICOS didapatkan empat artikel. Artikel yang sesuai kriteria eligible menurut instrumen critical appraisal Arrive 2.0 berjumlah empat artikel. Desain penelitian artikel seluruhnya adalah true experimental dengan populasi tikus dislipidemia yang diberi hesperidin. Hasil dari semua artikel menunjukan penurunan pada kadar lipid (menurunnya K-total, TG, K-LDL, dan meningkatnya K-HDL) secara signifikan (p < 0,05). Proses yang terlibat dalam perbaikan profil lipid pada penelitian ini adalah inhibisi HMG-KoA reduktase, ACAT, dan regulasi mRNA, C-FABP, dan H-FABP yang berperan dalam metabolisme lemak. Maka, hesperidin dapat menurunkan kadar lipid tikus dislipidemia, namun penelitian ini masih bersifat kualitatif dan disarankan untuk peneliti selanjutnya untuk melakukan kajian dengan metode kuantitatif (meta analysis).
Abstract. Game online are games that are played at the same time even though they are not played in the same place. Faculty of Medicine students are students who are currently studying medical studies. Faculty of Medicine students are known for their busy schedules and many assignments, so they play game online to overcome boredom. Game online addiction can be understood as an excessive attitude towards the use of digital tools to play game online, makes players unable to control attitudes and emotions caused by excessive attitudes, and can have an impact on social behavior problems, especially at the emotional level. The purpose of this study was to analyze the relationship between game online addiction and emotional levels in medical students at the Islamic University of Bandung. In the results of this study it was revealed that of the 114 students of the Faculty of Medicine at the Islamic University of Bandung, the dominant ones were not addicted to game online (81.6%) and had good emotions in playing game online (66.7%). From the results of this study it was found that the value of P = 0.490 which stated that there was no relationship between game online addiction and emotional levels in students of the Faculty of Medicine, Islamic University of Bandung. This is based on the existence of several things that can affect emotional levels such as student achievement and also good emotional intelligence. Abstrak. Game online adalah game yang dimainkan dalam waktu yang bersamaan walaupun tidak dimainkan di tempat yang sama. Mahasiswa Fakultas Kedokteran merupakan mahasiswa yang sedang belajar dalam studi kedokteran. Mahasiswa Fakultas Kedokteran dikenal dengan jadwal yang padat dan juga tugas yang banyak, sehingga mereka bermain game online untuk mengatasi jenuh. Kecanduan game online dapat dipahami sebagai sikap berlebihan terhadap penggunaan alat digital untuk bermain game online, membuat pemain tidak dapat mengontrol sikap dan emosi yang disebabkan oleh sikap berlebihan, dan dapat berdampak pada masalah perilaku sosial terutama pada tingkat emosional. Tujuan dari penelitian ini adalah untuk menganalisa hubungan kecanduan game online terhadap tingkat emosi pada mahasiswa fakultas kedokteran Universitas Islam Bandung. Pada hasil penelitian ini terungkap bahwa dari 114 orang mahasiswa Fakultas Kedokteran Universitas Islam Bandung dominan tidak mengalami kecanduan game online (81,6 %) dan memiliki emosi baik dalam bermain game online (66,7%). Dari hasil penelitian tersebut didapatkan bahwa nilai P = 0,490 yang menyatakan bahwa tidak terdapat adanya hubungan antara kecanduan game online terhadap tingkat emosi pada mahasiswa Fakultas Kedokteran Universitas Islam Bandung. Hal tersebut didasarkan pada adanya beberapa hal yang dapat mempengaruhi tingkat emosi seperti prestasi belajar mahasiswa dan juga kecerdasan emosional yang bagus.
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