Pulmonary disease is a worldwide public health problem that reduces the life quality and increases the need for hospital admissions as well as the risk of premature death.A common problem is the significant shortage of lungs for transplantation as well as patients must also take immunosuppressive drugs for the rest of their lives to keep the immune system from attacking transplanted organs. Recently, a new strategy has been proposed in the cellular engineering of lung tissue as decellularization approaches. The main components for the lung tissue engineering are: (1) A suitable biological or synthetic three-dimensional (3D) scaffold, (2) source of stem cells or cells, (3) growth factors required to drive cell differentiation and proliferation, and (4) bioreactor, a system that supports a 3D composite biologically active. Although a number of synthetic as well biological 3D scaffold suggested for lung tissue engineering, the current favorite scaffold is decellularized extracellular matrix scaffold. There are a large number of commercial and academic made bioreactors, the favor has been, the one easy to sterilize, physiologically stimuli and support active cell growth as well as clinically translational. The challenges would be to develop a functional lung will depend on the endothelialized microvascular network and alveolar-capillary surface area to exchange gas. A critical review of the each components of lung tissue engineering is presented, following an appraisal of the literature in the last 5 years. This is a multibillion dollar industry and consider unmet clinical need. K E Y W O R D S in vivo, lung, scaffold, stem cell, tissue engineering
Polylactide-co-glycolide acid (PLGA) is known as a biodegradable and biocompatible polymer. This polymer has been highly used in tissue engineering. In this study, the biological behavior of Schwann cells (Rat) was investigated in co-culture with L lysine/gelatine coated PLGA nano-fiber. In this study, PLGA was dissolved in a hexafluoro propanol based solvent and nanofiber prepared by an electronic method. They were coated with gelatin and poly-L-lysine individually. These polymer properties were investigated by Scanning Electron Microscopy (SEM) analysis and contact angle measurement. After extraction of rat Schwann cells, the cells were cultured in three groups of nano-fiber; nano-fiber PLGA, nano-fiber gelatine coated PLGA and nano-fiber poly-L-lysine coated PLGA. Cell death and Cell proliferation were evaluated by Acridine orange staining (living cell with a green nucleus and dead cell with an orange nucleus) and morphology was investigated by SEM in 2, 4 and 6 days. The diameter of electronic nanofiber PLGA was between 270 to 700 nm. Average contact angles of PLGA, PLGA coated with gelatine, coated with poly-L-lysine and PLGA were 40.12, 64.58 and 107.66degrees, respectively. The findings showed a significant reduction of cell proliferation in PLGA nanofiber ( it was important than PLGA without nano-fiber (P <0.05)). But, this amount was increased in nanofiber which coated with poly-L-lysine and gelatine. PLGA nanofiber-poly-L-lysine was more biocompatible than PLGA nanofiber-gelatine and this comparison was done with rat Schwann cells.
The purpose of writing this article is an analytical study of Talibov Tabrizi's Thoughts as one of the intellectuals supporting the Iranian people who is in the middle of the background of the Iranian Constitutional Revolution and the realization of this revolution (1284 AH) in Iranian society. He is one of the influential people in the realization of the Constitutional Revolution, to whom a part of the new ideas in the constitutional period Iran are dedicated. He was one of the pioneers of constitutionalist politics and is one of the first modern thinkers in Iran in the field of thought making. He has also brought aspects of cultural and political modernity to Iranian culture. His ideas and thoughts on cultural, social, political, and economic issues are in a Rupture from traditional science and education. New scientific topics and philosophical foundations of the modern world were the main foundations of his intellectual system. Based on what he learned from modernity, he commented on political issues and came up with new ideas on cultural, social and political issues. He is one of the promoters of natural sciences and modern social and political thought and the representative of the intellectual currents of his time, one of the followers of the originality of reason and experimental philosophy. A believer in philosophical liberalism, he generally rejects the medieval way of thinking and the political system associated with it. His political views are a combination of political liberalism and social democracy, and he seeks to establish a democratic system. Emphasizes the liberty right and the rule of law. He believes in the rule of the elite, that is, the people of knowledge and thought of the agents of reform and progress. It preaches national sovereignty and the right of nations to determine their own destiny.
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