With a broad ethnopharmacological tradition in Brazil, Montrichardia linifera has been reported as a potent antirheumatic, antimicrobial, and antiprotozoan agent. However, there is a lack of studies on its effect on bacterial biofilm formation and Schistosoma mansoni worms. This study reports the effects of antibacterial, antibiofilm, and antischistosomal properties of leaf extracts of M. linifera. Phytochemical screening and identification of the main compounds of the extracts were performed. All the extracts evaluated showed antibacterial activity at the concentrations tested. We checked for the presence of flavonoids and derivatives of phenolic acids by the presence of spectra with bands characteristic of these classes in the sample analyzed. The antibacterial assays showed that the best MICs corresponded to 125 µg/mL against Enterococcus faecalis ATCC 29212 in all fractions. The ethanolic and methanolic extracts showed the ability to inhibit biofilm of Staphylococcus aureus ATCC 25123. For the antischistosomal activity, only the acetone and ethyl acetate extracts had a significant effect against helminths, with potent activity at a concentration of 50 µg/mL, killing 100% of the worms after 72 h of incubation. The M. linifera leaf extracts showed antibacterial activity, biofilm inhibition capacity, and anthelmintic activity against S. mansoni.

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The tannic acid is a polyphenol with several properties that give it different applications, including leather and pharmaceutical industry. It belongs to the group of water soluble metabolites, and has the ability to complex macromolecules and metal ions, which gives it antioxidant, antimicrobial and healing activity. Therefore, such properties can be used to develop technologies related to wound healing systems. This prospective study summarizes bibliographic information about the use of tannic acid in topical formulations for healing skin wounds. The data were collected through the search tool available in patent databases (INPI, USPTO, EPO, WIPO, DERWENT) and articles (Web of Science) about the application of tannic acid in skin wound healing system. In recent decades, there has been growth in number of searches for elucidation of antimicrobial and antioxidant activities of tannic acid, and its incorporation in biomaterials in the pharmaceutical field. The United States, Japan and China stood out in inventions and publishing articles. The Brazilian biodiversity is immense, although underexplored and poorly study about extraction and properties of tannins in topical formulations, which lacks encourages to research technologies for healing system more effective and cheap.

A esquistossomose é uma doença parasitária que tem o homem como hospedeiro definitivo e comum em locais sem saneamento básico. Esta pesquisa tem o objetivo de realizar uma prospecção científica e tecnológica sobre a esquistossomose no Estado do Maranhão. A prospecção tecnológica foi realizada por meio da busca nas bases: EPO, USPTO, INPI e DII, e por busca em artigos científicos nas bases: Scielo, Bireme, PubMed, Web of Science, Scopus e Science Direct, de 1997 até 2019. Os resultados para patentes mostraram que a base USPTO obteve o maior número de publicações, com 1.879 registros. Nos resultados para prospecção científica, observa-se que para o descritor “Schistosoma mansoni” a base Bireme lidera com 8.063 e para o "Schistosoma mansoni" and "Maranhão" diminui para 21 artigos.  Dessa forma, percebe-se que é necessário mais incentivo e investimentos para a realização de mais pesquisas relacionadas à esquistossomose, isso devido ao seu impacto na saúde pública e os poucos tratamentos quimioterápicos encontrados.