The aim of this study was to evaluate the association between timing of permanent tooth emergence with overweight and obesity in children from Brazilian Amazon region. The studied population consisted of 192 children, 09 to 12 year-old, from public schools at Manaus, Amazonas-Brazil. Clinical examination was performed and the tooth emergence was evaluated according to the number of permanent erupted teeth. Body mass index z-score was calculated. For the statistical analysis 'Overweight/obese' group was compared with 'Normal weight' group in a case to control ratio 1:2. The t-test based on age was used for means comparison between the groups. A linear regression analysis using age and gender as co-variants was used. The established alpha was 5%. One hundred twenty-seven children were classified as normal weight and 65 were classified as overweight/obese (49 were overweight and 16 were obese). Overweight/ obesity condition was associated with the gender, in which boys had a higher chance to present higher weight conditions (OR=1.84; CI 95% 1.06-3.37; p=0.04). The mean number of permanent teeth was higher in the overweight/obesity group (p<0.001). Linear regression analysis demonstrated that nutritional status, gender and age were strongly associated with number of permanent erupted teeth (p<0.05). In conclusion, our study demonstrated that timing of permanent tooth emergence is associated with overweigh/obesity in children from Manaus, Brazil.
The aim of this study was to investigate the association between genetic polymorphisms in MMP8, MMP13, and MMP20 with caries experience and developmental defects of enamel (DDE) in children from the Amazon region of Brazil. Den tal caries and DDE data were collected through clinical examination from 216 children. Genomic DNA was extracted from saliva, and genotyping of selected polymorphisms in MMP8 (rs17099443 and rs3765620), MMP13 (rs478927 and rs2252070), and MMP20 (rs1784418) was performed using TaqMan chemistry and endpoint analysis. χ2 or Fisher’s exact tests were used to compare allele and genotype distributions between children with caries experience and caries-free children and between DDE-affected and -unaffected children with an established alpha of 5%. The polymorphism rs478927 in MMP13 was associated with caries experience and DDE (p < 0.05). The analysis performed comparing children with both conditions (caries experience plus DDE) and children with neither of the conditions (caries-free chil dren without DDE) demonstrated that children carrying the MMP13 rs478927 TT genotype were more likely to have concomitant occurrence of these two conditions (OR = 5.8, 95% CI 2.1–15.8; p = 0.0003). In conclusion, the genetic polymorphism rs478927 in MMP13 was associated with caries experience and DDE.
Background Oestrogen (ES) and growth hormone (GH) are hormones that may have a role in caries aetiology and developmental defects of enamel (DDE) since their receptors (ERs and GHR) are expressed during amelogenesis. Aim To evaluate whether genetic polymorphisms in the genes that codify the ERα (ESR1) and GHR are associated with caries experience and DDE in children. Design Two hundred and sixteen children of both genders, aged 9‐12 years, were examined and classified according to caries and DDE phenotype. Genomic DNA was extracted from buccal cells in saliva. Genetic polymorphisms in ERS1 (rs1884051 and rs12154178) and GHR (rs297305, rs2940913, rs2910875, and rs1509460) were genotyped using TaqMan chemistry. Data were analysed by PLINK, while the chi‐square test was used to compare allele and genotype distributions (alpha of 5%). Results A total of 131 children (60.7%) had caries experience, and 43 (19.9%) presented DDE. Genotype and allele distributions were not associated with caries experience (P > 0.05). Genotype and allele distributions between DDE, affected and unaffected, were associated with the polymorphism rs12154178 in ESR1 (P = 0.01 and P = 0.001, respectively) and with the polymorphism rs1509460 in GHR (P = 0.05 and P = 0.02, respectively). Conclusions Genetic polymorphisms in ERS1 (rs12154178) and GHR (rs1509460) are associated with DDE.
AimTo evaluate the association between dental caries and nutritional status in a group of Brazilian schoolchildren, from Manaus. The studied population consisted of 197 students (10–12-year-olds) from public schools at Manaus, Amazonas, Brazil.Materials and methodsA clinical examination was carried out and the decay-missing-filled-teeth index for primary and permanent teeth (dmft and DMFT) was used to evaluate dental caries. Body mass index Z-score was calculated using variables such as individual height, weight, age, and gender. The nutritional status was classified as underweight, eutrophic, overweight, and obese. One-way ANOVA and Tukey's posttests were used for means’ comparison between groups. The established alpha was 5%.ResultsEighty-one (41.1%) children were caries-free. Five (2.5%) children were underweight; 127 (64.5%) were eutrophic; 49 (24.9%) were overweight; and 16 (8.1%) were obese. The mean dmft/DMFT index was 1.67 (2.05). Obese children had more caries experience than eutrophic and overweight children (p < 0.05).ConclusionOur study demonstrated that dental caries is associated with obesity in school children from Manaus.How to cite this articleVasconcelos K, Evangelista S, et al. Assessing the Association between Dental Caries and Nutritional Status in Children from the Brazilian State of Amazonas. Int J Clin Pediatr Dent 2019;12(4):293–296.
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