Association between genetic polymorphisms in DEFB1 and microRNA202 with caries in two groups of Brazilian children

Oliveira, Daniela Silva Barroso de; Oliveira, Sara; Dutra, André Luiz Tannus; Santos, Adriana S; Praxedes, Ananda Deva Noronha; Belém, Leandro Coelho; Antunes, Lívia Azeredo Alves; Lips, Andrea; Filho, Paulo Nelson; Silva, Léa Assed Bezerra da; Alves, Gutemberg Gomes; Küchler, Érika Calvano

doi:10.1016/j.archoralbio.2018.04.010

Cited by 19 publications

(13 citation statements)

References 52 publications

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“…Except for 2 variants (rs11362 and rs1799946) in DEFB1 gene, variants in other genes in our study were not found to be correlated with dental caries, which was not in line with some previous studies conducted among other populations (Anjomshoaa et al., 2015; Gerreth et al., 2017; Kuchler et al., 2018). The explanation for the inconsistent findings across studies is that genetic heterogeneity may lead to some true association absent in an independent sample (Greene et al, 2009; Ioannidis, 2007; Oliveira et al., 2018). If a small mutation at interacting loci could significantly change the statistical power of an individual study to replicate main effects, different results across independent samples were exhibited (Oliveira et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The explanation for the inconsistent findings across studies is that genetic heterogeneity may lead to some true association absent in an independent sample (Greene et al, 2009; Ioannidis, 2007; Oliveira et al., 2018). If a small mutation at interacting loci could significantly change the statistical power of an individual study to replicate main effects, different results across independent samples were exhibited (Oliveira et al., 2018). Therefore, findings from an individual study could not be directly extrapolated to other populations with different genetic background.…”

Section: Discussionmentioning

confidence: 99%

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An association analysis for genetic factors for dental caries susceptibility in a cohort of Chinese children

Zhou

et al. 2020

Oral Diseases

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Objective To comprehensively investigate the effects of 25 variants in 15 genes on dental caries susceptibility in a cohort of Chinese children. Methods A total of 25 variants in 15 genes were genotyped with MassARRAY iPLEX system and analyzed in 265 healthy controls and 254 children affected by dental caries with different dmft scores. The children with dental caries were stratified into “mild group” (scores from 1 to 3), “moderate group” (scores from 4 to 6), and “severe group” (scores from 7 to 14). Results The association analysis revealed that rs11362 of defensin β1 (DEFB1) was significantly associated with dental caries susceptibility (OR = 2.447, p = 1.165E−04). Furthermore, rs11362 was positively correlated with the severity of dental caries. For another selected variant of DEFB1, rs1799946 was significantly associated with dental caries susceptibility in the severe group (OR = 0.473, p = 3.70E−03) and also significant in the group consisted of moderate and severe subjects (OR = 0.623, p = .033). The results from logistic regression in additive, dominant, and recessive models also exhibited the similar patterns. Conclusion Out of 25 selected variants, only 2 of DEFB1 gene (rs11362 and rs1799946) were significantly associated with dental caries susceptibility in children.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An association analysis for genetic factors for dental caries susceptibility in a cohort of Chinese children

Zhou

et al. 2020

Oral Diseases

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“…Taking the molecules of the innate immune system into consideration, this study focused on SNPs in DEFB1 due to their previous association with clinical conditions such as dental caries (Lips et al 2017, Oliveira et al 2018, periodontal disease (Zhong et al 2019), pulpal and periapical pathosis (Paris et al 2009, Lee & Baek 2012 and the potential impact on the protein level (Nurjadi et al 2013, Polesello et al 2015. Some studies suggested that gene regulatory SNPs in DEFB1 influence gene expression and protein production (Nurjadi et al 2013, Polesello et al 2015.…”

Section: Discussionmentioning

confidence: 99%

“…2017, Oliveira et al . 2018), periodontal disease (Zhong et al . 2019), pulpal and periapical pathosis (Paris et al .…”

Section: Discussionmentioning

confidence: 99%

Association between genetic polymorphisms in the promoter region of the defensin beta 1 gene and persistent apical periodontitis

et al. 2020

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Aim To evaluate the association between the promoter region of defensin beta 1 (DEFB1) genetic polymorphisms and persistent apical periodontitis (PAP) in Brazilian patients. Methodology Seventy‐three patients with post‐treatment PAP (PAP group) and 89 patients with root filled teeth with healed and healthy periradicular tissues (healed group) were included (all teeth had apical periodontitis lesions at the beginning of the treatment). Patients who had undergone at least 1 year of follow‐up after root canal treatment were recalled, and their genomic DNA was extracted from saliva. Two single nucleotide polymorphisms (SNPs) in DEFB1 at the g. −52G>A (rs1799946) and g. −20G>A (rs11362) positions were analysed using real‐time polymerase chain reaction. The chi‐squared test was performed, and the odds ratios were calculated using Epi Info 3.5.2. Logistic regression analysis in the codominant model, using the time of follow‐up as a variable, was used to evaluate the SNP‐SNP interaction. All tests were performed with an established alpha of 0.05 (P = 0.05). Results For the rs11362 polymorphism in the codominant and recessive models, patients who carried two copies of the T allele had a significantly lower risk of developing PAP (P = 0.040 and P = 0.031, respectively). For the rs1799946 polymorphism in DEFB1 in the codominant and recessive models, carrying one copy of the T allele significantly increased the risk of developing PAP (P = 0.007 and P = 0.031, respectively). In the logistic regression, both polymorphisms were associated with PAP as well as the SNP–SNP interaction (P < 0.0001). Conclusions Polymorphisms in DEFB1 genes were associated with the development of post‐treatment persistent apical periodontitis.

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“…Associação entre polimorfismos nos genes que codificam MMP8, MMP13 e MMP20 com lesões de cárie e DDE Pesquisas de associação são instrumentos para a identificação de variantes genéticas que predispõem a doenças complexas e multifatoriais (Li et al, 2006 , 1997), empregados em estudos prévios sobre associações entre polimorfismos genéticos e cárie dentária (Slayton et al, 2005;Deeley et al, 2008;Patir et al, 2008;Lips et al, 2017;Oliveira et al, 2018).…”

Section: Avaliação Dos Defeitos Do Desenvolvimento Do Esmalte (Ddes)unclassified

Associação entre lesões de cárie dentária e defeitos do desenvolvimento do esmalte com o índice de massa corporal e com polimorfismos nos genes que codificam as metaloproteinases 8, 13 e 20, em crianças de Manaus - AM

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Association between genetic polymorphisms in DEFB1 and microRNA202 with caries in two groups of Brazilian children

Cited by 19 publications

References 52 publications

An association analysis for genetic factors for dental caries susceptibility in a cohort of Chinese children

An association analysis for genetic factors for dental caries susceptibility in a cohort of Chinese children

Association between genetic polymorphisms in the promoter region of the defensin beta 1 gene and persistent apical periodontitis

Associação entre lesões de cárie dentária e defeitos do desenvolvimento do esmalte com o índice de massa corporal e com polimorfismos nos genes que codificam as metaloproteinases 8, 13 e 20, em crianças de Manaus - AM

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