BACKGROUNDAcute Lymphoblastic Leukaemia (ALL), a malignancy of lymphoid lineage cells, has excellent prognosis in children. Leukemia is the most prevalent childhood cancer and Acute Lymphoblastic Leukemia (ALL) constitutes 75% of all cases. The most frequent presenting symptoms are fever, weight loss and pallor. Early detection of clinical symptoms positively affects timely diagnosis. AIMS & OBJECTIVESThe objectives of the present study were to assess frequency of presenting symptoms, laboratory data and prognostic factors in children with diagnosis of ALL. MATERIALS & METHODSThe present study ( 2014) was performed in the hematology section of Department of Pathology of Gajra Raja Medical College, Gwalior over a period of 12 months from 1st October 2013 to 30th September 2014. This was a prospective study. The blood samples were received from various departments of Jayarogya hospital especially from the Pediatric and Medicine departments. RESULTSOut of the 37 cases diagnosed as Acute Lymphoblastic Leukemia, 25(67.57%) were male and 12(32.43%), were female, (male:female ratio: 2.1:1). 43.35% of patients which comprises highest number of cases belonged to 11-20 years of age group. The most frequent presenting symptoms was fever (83.78%) followed by weakness (70.27%) and loss of appetite (27% while most frequent presenting sign was pallor (86.48%) followed by lymphadenopathy (67.57%) and splenomegaly (48.65%)). Complete blood cell count was abnormal in all of the patients, and pancytopenia was detected in 10.81% of the patients. Of all the patients, 91.89% had abnormal white blood cell (WBC) count at presentation, 10.81% had leucopenia and 80% had leucocytosis. FAB L1 subtype was more common as compared to FAB L2 subtype. CONCLUSIONIn our study (2014), Acute Lymphoblastic Leukemia was more prevalent in males than in females and more common in childhood than in adult. FAB L1 subtype was more common as compared to FAB L2 subtype.
Background: Since covid has emerged as the most dreadful global health crisis and data on diagnostic profile and morbidity mortality indicators in it is still limited, we propose to study the correlation of morbidity and mortality with values of Inflammatory markers in these patients. To STUDY variations in INFLAMMATORY MARKERS IN Aim: COVID19 PATIENTS and correlating it with severity of disease. using CLIA technique, four Materials and Methods: inflammatory markers ( TROPONIN -I , ferritin, procalcitonin, IL -6) were studied among 400 patients. This was correlated with severity of the disease outcome among the patients. Among the inflammatory markers we studied Results: IL-6 ,Ferritin,Troponin -I ,Procalcitonin. Raised values of IL-6 and raised ferritin levels were associated with severity. Troponin I (91%) ,Ferritin( 70.8%) ,Calcitonin ( 78.5%) were increased but showed no association with mortality. However only IL-6 seems to be associated with increased mortality among Covid patients. On the basi Conclusion: s of findings in this study Inflammatory markers particularly IL -6 and ferritin can be concluded as important predictors of disease severity and outcome.These parameters can be used to identify high-risk patients at resource-limited settings
INTRODUCTION Dysmegakaryopoiesis is characterized by various Megakaryocytic alterations in bone marrow and includes both dysplastic and non dysplastic features.Dysplastic changes are mostly seen in myelodysplastic syndrome however megakaryocyte alteration have also been noted in some bone marrow aspiration in non myelodysplastic conditions. AIMS OBJECTIVE To evaluate changes in megakaryocytes in various hematological conditions in bone marrow aspiration examination. MATERIAL AND METHODS Study was done at Central Pathology lab in the Department of Pathology GAJRA RAJA MEDICAL COLLEGE GWALIOR over a period of 1.5 year FROM NOV 2019 TO MAY 2021.Total 84 bone marrow were received out of 14 were dilute so excluded from study and results were prepared from 70 cases.Age range was 9 months to 75 years RESULTS AND OBSERVATIONS In this study out of 70 patients, 43 were male and 27 were female.Patients were categorised into neoplastic and non neoplastic category.Out of 70 cases 46 were non neoplastic forming majority while 24 were neoplastic. Out of non neoplastic, megaloblastic anemia was most common while acute leukemia was most frequent in neoplastic category.Bone marrow was evaluated for cellularity. 47 were hypercellular marrow forming majority with 15 cases showing normal cellularity and 08 as hypocellular. Acute leukemia and megaloblastic anemia were two conditions which had hypercellular marrow. The number of the megakaryocytes was considered normal when one megakaryocyte per 3 low power fields was encountered,increased if more than two megakaryocytes per low power field were seen and decreased when one megakaryocyte per five to ten low power fields was documented and absent when no megakaryocytes were seen per ten low power field. Our study showed 27 cases of megakaryocytic hypocellularity, 22 cases normal number of megakaryocytes and 18 as increased number of megakaryocytes. Normally megakaryocytes have four to sixteen nuclear lobes. Immature megakaryocytes were defined as young forms of megakaryocytes with scant bluish cytoplasm and lacking lobulation of the nucleus. Dysplastic megakaryocytes are those with single, multiple/separated nuclei. Micro megakaryocytes were defined as megakaryocytes whose size was that of large lymphocyte or monocyte and which had a single / bi-lobed nucleus. Our study – showed normal megakaryocyte morphology in 32/70 (45%) cases and 35/70 (50%) were with altered morphology. CONCLUSION Dysplastic Morphologic changes in megakaryocyte were not only seen in MDS but also in various non MDS conditions which should be considered during diagnosis.Understanding and detailed knowledge of changes in megakaryocytes,including both cellularity and morphology,can improve the diagnostic accuracy for a wide range of hematological disorders
Background: Dengue is common mosquito born viral disease of human caused by dengue virus .Dengue virus belongs to family of Flaviviridae and there are 4 serotypes of virus which are DENV-1 to DENV -4. Across the world about 100 million infections are detected every year in which 5,00,000 manifest in hemorrhagic cases.By clinical presentation and laboratory test, infection with dengue can be diagnosed. The study was from March 2020 to NovemberMethod: 2021.Total 200 samples were taken .All the patients suspected for dengue were considered in this study and after ELISA only positive cases for NS1 were undertaken for molecular study. A total 200 clinically suspected samples wereResult: taken .Out of 200 samples 120 (60.0%) were dengue positive ,80 (40.0%) were dengue negative .Out of 120 serologically dengue positive samples, 81 (67.5%) were positive for NS1 antigen and 39 were positive for IgM by ELISA. Out of 120 dengue posistive cases fever was the most common clinical presentation in 120 (100%) and thrombocytopenia was the most common hematological finding present in 102 (85.0 %) cases . Out of 81 (67.5%) dengue NS1 antigen positive samples on which molecular study was done showed, 22 (27.16%) positive for dengue virus RNA and 59 (72.84%) negative for dengue virus RNA by conventional PCR method. Awareness of clinical features, laboratoryConclusion: findings consisting of hematological and serological parameters as well as molecular study are important for diagnosis and management of dengue and dengue like illness.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.