Clinicopathological Study of Acute Lymphoblastic Leukemia - A Multiparameter Study

Jatav, Jagannath; Jain, Bharat; Niranjan, Amit

doi:10.18410/jebmh/2015/1184

Cited by 3 publications

(4 citation statements)

References 9 publications

(12 reference statements)

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“…Our present study findings are similar to Jatav et al 8 Their study was conducted at Gajra Raja Medical College, Gwalior, and they found AML to be more common than ALL which was at 55.4% and 44.6% respectively.…”

Section: Discussionsupporting

confidence: 91%

Clinico-hematological study of leukemias in a hospital-based setup

et al. 2021

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Background: Leukemia, the malignant proliferation of hematopoietic cells, accounts for a major portion of cancer globally. Types of leukemia are necessary for effective therapy as prognosis, and survival rates are different for each type of leukemia. The objective of the study was to know the relative incidence of leukemia in Silchar Medical College and Hospital, Assam. This study also aims to know the clinical manifestations of leukemia and their hematological correlation.Methods: It was a retrospective study of 60 patients carried out in the Department of Pathology in SMCH, Assam, over a period of 2 years from April 2019 to March 2021. Diagnosis was based on peripheral blood count, peripheral blood smear and bone marrow examination for morphology, along with cytochemistry study whenever required.Results: In this study, acute leukemia was more prevalent than chronic leukemia. The most common form was CML followed by AML, ALL and then CLL. Male predominance was observed in this study with male: female ratio = 1.7:1. Conclusions: In our study, Acute leukemia was more prevalent than chronic leukemia. Leukemia affected male more than female. In this study, the frequency of AML is more than that of ALL but number of cases of CML exceeds that of AML.

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Section: Discussionsupporting

confidence: 91%

Clinico-hematological study of leukemias in a hospital-based setup

et al. 2021

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“…In this study, the AML-to-ALL ratio was approximately 1.5:1. The finding was consistent with the findings of Kassahun et al, Idris et al, and Jatav et al 1,9,10 This study is a hospital-based study and only those patients who visited us have been included; hence, the findings are not externally valid.…”

Section: Discussionsupporting

confidence: 90%

Clinico-Hematological Profile of Acute Leukemia Cases in Bihar: A Multiparameter Study in a Tertiary-Care Hospital

et al. 2022

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Objective The actual incidence and demographic profile of hematological malignancies are unknown in Bihar because of lack of population-based cancer registry (PBCR) data and specialized tertiary cancer center facilities. The objective of this study was to estimate the prevalence, clinico-hematological profile and subtyping of acute leukemia cases by retrospective medical records. Materials and Methods A retrospective study was conducted in the Department of Hematology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India, over 2 years from July 2019 to June 2021. A total of 176 cases with relevant clinical features and hematological findings were involved in the study. Medical records were studied and data were retrieved. Statistical Analysis Data were recorded and analyzed using SPSS version 25. Results A total of 176 cases with relevant clinical features and hematological findings were involved in the study. Acute myeloid leukemia (AML) was most prevalent (52.8%), followed by acute lymphoblastic leukemia (ALL) (34.1%) and unclassified acute leukemia cases (13.1%). Flow cytometry correlation was available in 150 cases. The ratio of males (62.5%) to females (37.5%) is 1.6:1. There was statistically significant difference in physical examination findings between AML and ALL patients. Splenomegaly, lymphadenopathy, and sternal tenderness were more often seen in ALL than in AML patients (p < 0.05). Pallor was more significantly associated with AML than with ALL patients (p < 0.05). Anemia and leucocytosis were found to be significantly associated with acute leukemia patients (p < 0.000). Conclusion AML M2 was the most common subtype of AML, and B-ALL was the most common subtype of ALL cases.

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“…When the results of peripheral blood tests lead to leukemia, then bone marrow examination, immunophenotypes, and cytogenetics must be carried out immediately to make a diagnosis. 6 Our result found 42 patients (84%) with thrombocytopenia, as one of hematopoiesis dysfunction results. Signs and symptoms related to bleeding such as melena, petechiae, bruising, nosebleed, or purpura.…”

Section: Discussionmentioning

confidence: 46%

“…Variations in the infiltration of leukemia cells into organs are related to the time of diagnosis. 6 Hepatomegaly often occurs in patients with hemoglobin <10 g / dl. In diseases that arise more slowly, hepatomegaly is followed by splenomegaly, lymphadenopathy, and hyperleukocytosis.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Study of Clinical and Laboratory Profiles of Patients with Acute Lymphoblastic Leukemia at Dr. Soetomo Hospital Surabaya

Putri

Ugrasena

Hernaningsih

2019

BHSJ

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Introduction: Considering the high number of acute lymphoblastic leukemia (ALL) and it being the type of cancer with the highest fatality rate among the children, this study seeks to determine the epidemiological description of the clinical and laboratory profiles of patients with ALL.Methods: This research used a descriptive study by using medical data record of patients with ALL. The research variables were gender, age, leukemia history of the patient’s family, nutritional status, symptoms and signs, laboratory examination, ALL subtypes, risk factors, and result outcomes. All data presented descriptively.Results: From a total of 50 patients, 54 % of them were male aged 1,5 – 10 years old. 84% of the patients’ family had no medical record related to leukemia. 42% of the patient malnutrition. Pale (78%), fever (64%), pain (32%), hepatomegaly (38%), lymphadenopathy (28%), splenomegaly (26%), patients with anemia (82%), leukocytosis (38%), thrombocytopenia (54%). The highest types were ALL–LI (68%), SR-ALL (54%), and remission outcome reached 82%.Conclusion: Insidence higher in male, aged 1,5 – 10 years old, malnourished at the start of the diagnosis. Most of the patients’ family had no medical history of leukemia. Symptoms and medical signs mostly appeared were pale, fever, and bone/joint pain. The physical examination showed hepatomegaly, lymphadenopathy, and splenomegaly and laboratory first test showed the patients had anemia, leukocytosis, and thrombocytopenia.

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Clinicopathological Study of Acute Lymphoblastic Leukemia - A Multiparameter Study

Cited by 3 publications

References 9 publications

Clinico-hematological study of leukemias in a hospital-based setup

Clinico-hematological study of leukemias in a hospital-based setup

Clinico-Hematological Profile of Acute Leukemia Cases in Bihar: A Multiparameter Study in a Tertiary-Care Hospital

Epidemiological Study of Clinical and Laboratory Profiles of Patients with Acute Lymphoblastic Leukemia at Dr. Soetomo Hospital Surabaya

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