Our NPD is better than standard wound care procedures and cost-effective for management of PU.

Reduced levels of MMP-8 and an increased rate of healing were found in patients allocated to treatment with a novel negative pressure device as compared to wet to moist gauze conventional dressing. The novel NPWT device used in this study reduced exudate production and enhanced the rate of formation of red granulation tissue.

Introduction: Severe Acute Respiratory Infection (SARI) is an important cause of morbidity and mortality worldwide, caused by a large number of viral and bacterial agents. PARV4 is a recently identified virus detected in human blood and variety of tissues, but its disease association with SARI could not be established.Objective: In the present case control study, we aim to investigate the association of PARV4 with SARI. Methods: The Nasal and Throat swab (NS/TS) samples of 241 cases and 146 healthy controls were tested for most common respiratory viruses and PARV4 by real-time PCR. Results: PARV4 was detected in 64(26.55%) SARI cases and only one healthy control (0.68%). PARV4 was the most common viral agent detected in SARI cases. A strong association of PARV4 is seen with severe respiratory illness. Conclusion: Detection of PARV4 in a significantly higher number of SARI cases, in comparison with controls, suggests association of PARV4 with SARI. PARV4 genotype 2 is the only circulating strain detected in our study.

The conventional methods of treatment of pressure ulcers (PUs) by serial debridement and daily dressings require prolonged hospitalisation, associated with considerable morbidity. There is, however, recent evidence to suggest that negative pressure wound therapy (NPWT) accelerates healing. The commercial devices for NPWT are costly, cumbersome, and electricity dependent. We compared PU wound healing in traumatic paraplegia patients by conventional dressing and by an innovative negative pressure device (NPD). In this prospective, non-randomised trial, 48 traumatic paraplegia patients with PUs of stages 3 and 4 were recruited. Patients were divided into two groups: group A (n = 24) received NPWT with our NPD, and group B (n = 24) received conventional methods of dressing. All patients were followed up for 9 weeks. At week 9, all patients on NPD showed a statistically significant improvement in PU healing in terms of slough clearance, granulation tissue formation, wound discharge and culture. A significant reduction in wound size and ulcer depth was observed in NPD as compared with conventional methods at all follow-up time points (P = 0·0001). NPWT by the innovative device heals PUs at a significantly higher rate than conventional treatment. The device is safe, easy to apply and cost-effective.

Scrub typhus, JEV and DENV are the main aetiological agents of AES in UP. DENV and JEV can no longer be considered paediatric diseases. The prevalence of non-JEV/DENV aetiology of AES increases in the monsoon and post-monsoon seasons.

Objective: This study was done to determine the cause effect relationship between pressure ulcers (PUs) and metabolic alterations in individual having PUs with Spinal Cord Injury (SCI) Methods: 123 SCI subjects with PUs were enrolled in the study. PUs were measured for surface area, exudate, depth and formation of granulation tissue using the pressure ulcers scale for healing tool. The nutritional status of subjects was assessed by measuring serum haemoglobin, albumin and transferrin levels at baseline (week 0), weeks 3 and 6 during follow-up.Results: An inverse correlation of wound size was observed with nutritional status at weeks 3 and 6. There was a significant increase (p < 0.001) in: Haemoglobin (10.7 -12.4 g/dl), Albumin (2.9 -4.04 g/dl) and Transferrin (174.1 -186.9 μg/dl) levels at the time of discharge. The size of PUs was drastically reduced up to 5.4 fold at the time of discharge. Conclusion:Given the high prevalence of malnutrition among subjects with PUs, performing a routine nutritional screening should result in early identification of residents with the risk of developing PUs. This article gives statistical evidence that healing of PUs is associated with an increase in Hb level and improving metabolic alterations. There seems to be a positive relationship between PU healing cascade and nutritional corrections. In future, this relation may be disclosed with newer intervention.

This study was planned to study the association of parvovirus 4 (PARV4) with Influenza‐like illness (ILI). A total of 1111 patients with a clinical diagnosis of ILI and 220 healthy controls were tested for Influenza A/HINI/and H3N2, Influenza B, and PARV4. Further sequencing was done to analyze the genotype distribution of parvovirus 4. Influenza A/HINI, A/H3N2, and B were detected in 334 (30.06%), 9 (0.81%), and 10 (0.9%) cases respectively. PARV4 was detected in 135 (12.15%) cases and one healthy control. Parvovirus 4 was significantly higher in cases as compared to controls (relative risk, 30.77%; p < .0006). Sequencing of 20 isolates suggests the dominance of genotype 2 in our region.

¼ 0.85). The GPE model also displayed adequate internal validation (optimism-adjusted AUC ¼ 0.81) and consisted of 12 predictors. Baseline age, back pain chronicity, pain intensity, disability, recent episodes of back pain, comorbid musculoskeletal pain, pain during rotation, and patient's expectation to recover were consistent predictors for nonrecovery. Morning stiffness longer than 30 minutes, kinesiophobia and pain catastrophizing were predictors in the disability and GPE models. Leg pain and depression were included only in the disability model, while sex was included only in the GPE model. Conclusions: This study presented the development and internal validation of three clinical prediction models for non-recovery in older adults with back pain. These models have potential to help primary care clinicians to determine which patients may not recover from a back pain episode. However, before being implemented in clinical practice, these models should be externally validated in a similar population, and an impact analysis should be conducted.