Purun Danau (Lepironia articulata (Retz.) Domin) has been shown to have antimalarial and antioxidant activity. This study aimed to standardize simplicia and extract of L. articulata by determining the value of its specific and non-specific parameters. A sampling of L. articulata rhizome was carried out in Guntung Manggis, Haur Gading, and Halat. The standardization method used was based on the Indonesian Herbal Pharmacopoeia and the General Standard Parameter of Extract. The organoleptic observations showed that L. articulata simplicia was reddish-brown in color, chelated taste, and had a specific odor. Microscopic observation showed parts of this plant: epidermis, cortex, endodermis, parenchyma, bundle vessels, and scalariform vessels. Ethanol-soluble extract content was 10.00-12.66%, water-soluble extract content 8.03-10.87%, drying shrinkage 7.10-7.33%, total ash content 2.03-2.52%, acid-insoluble ash 0.33-0.42%, Pb content 5.698-9.989 ppm, Cd content 0.300-0.500 ppm, Hg content 0.070-0.090 ppm. Ethanol extract of L. articulata rhizome contained alkaloids, flavonoids, tannins, glycosides, and saponins. The yield obtained was 8.05-11.23%, total ash content was 1.58-1.67%, acid-insoluble ash was 0.23-0.33%, and water content was 7.10-8.50%. Standardization of simplicia and ethanol extract of L. articulata rhizome has met the criteria.
Indonesia, which is located in the tropics, causes people's skin to easily experience premature aging and tan. Most of these cosmetic products contain dangerous synthetic chemicals. For this reason, cosmetic products with natural active ingredients or phytocosmetics that are effective and safe to use need to be developed. One of the typical natural plant plants from South Kalimantan that has the potential to be developed as a cosmetic preparation is Sungkai (Peronema canescens Jack). The aim of the study was to determine the antioxidant activity and sunscreen activity of Sungkai leaves. The method used for the determination of antioxidant activity is the DPPH method using a uv-vis spectrophotometer and for the determination of sunscreen activity using a uv-vis spectrophotometer. The results showed that the P. canescens plant extract contained anthraquinones, flavonoids, saponins, tannins, and phenols. P.canescens plants have an Inhibitory Concentration 50 (IC50 ) of 42.219±19.440 ppm and have sunscreen activity with spf (Sun Protecting Factor) values ??with concentrations of 600 ppm, 400 ppm, 200 respectively as follows: 24±0.31; 16±0.34; and 8±0.3. The conclusion of this study Sungkai (Peronema canescens Jack) has antioxidant activity and has sunscreen activity so that it has the potential to be developed into natural skin care.
This study aims to determine the best formulation for the peel-off mask Arachi or peanut (Arachis hypogaea L). Arachis hypogaea kefir as an active ingredient is added with variations in the concentration of F1 (0.5%) and F2 (2%) (w/v). Organoleptic tests, homogeneity, dry time, and pH were carried out on the peel-off mask that had been made. Antioxidant test (DPPH methods) was performed on masks F1 and F2. The results showed that the peel-off mask of A. hypogaea kefir had the best antioxidant activity at a concentration of 2% (F2) kefir with an IC50 value of 1.865 ppm and was very active. The characteristics of the peel-off mask have good physical stability, proven by not experiencing a change in color, odor, being homogeneous, having good dispersion power, and having a dry time ranging from 10-23 minutes. The pH value of the peel-off mask preparation is 4.52, and it is appropriate with SNI and the pH balance of normal human skin. The peel-off mask of A. hypogaea kefir can be produced because has good physical stability and antioxidant activity.
Pasak bumi sebagai obat tradisional pria telah digunakan oleh masyarakat melayu, khususnya orang Sumatra dan kalimantan, akan tetapi mekanisme secara molekuler belum dikatahui dengan jelas. Salah satu pendekatan yang dapat digunakan untuk mengetahui mekanisme pasak bumi sebagai obat tradisional yang bermanfaat mengatasi disfungsi ereksi adalah penambatan molekul. Penambatan melekul dilakukan dengan cara melihat interaksi ligand dengan reseptor. Ligand yang berasal dari pasak bumi adalah 5-methoxycanthin-6-one, 9-methoxycanthin-6-one, eurycomalactone, eurycomalide A, eurycomanone, eurycomaoside, laurycolactone A, longilactone, niloticin, picrasidine O. Sehingga kesepuluh ligand ini didocking menggunakan salah satu aplikasi docking yaitu PLANTS 1.1 untuk melihat ikatan dengan PDE5. Sebelum dilakukan docking terhadap ligand pasak bumi, terlebih dahulu dilakukan docking terhadap ligand Sildenafil untuk melhat nilai RMSD. RMSD ini diperlukan sebagai alat validasi metode, berdasarkan percobaan, nilai RMSD dari Sildenafil adalah 1,2517 A0. Hasil terbaik dari penambatan molekul pasak bumi adalah niloticin dengan skor doking -97,8802, sehingga nilai interaksinya terhadap reseptor sebesar 93,71% dari Sildenafil.Pasak bumi as traditional male medicine has been used by Malay people, especially Sumatra and Borneo people, but the molecular mechanism is not yet known clearly. One approach that can be used to determine the mechanism of the Pasak Bumi as a traditional medicine that is useful to overcome erectile dysfunction is docking molecules. Molecular docking is done by looking at the interaction of ligands with receptors. Ligands originating from the Pasak Bumi are 5-methoxycanthin-6-one, 9-methoxycanthin-6-one, eurycomalactone, eurycomalide A, eurycomanone, eurycomaoside, laurycolactone A, longilactone, niloticin, picrasidine O. docking application namely PLANTS 1.1 to see the bond with PDE5. Before docking Pasak Bumi ligand, it is first docking Sildenafil ligand to see the RMSD value. The RMSD is needed as a method validation method, based on experiments, the RMSD value of Sildenafil is 1.2517 A0. The best results from docking of the Pasak bumi molecule is niloticin with a doctor score of -97.8802, so interaction skor to the receptor is 93.71% of Sildenafil.Keywords: Pasak Bumi, PDE5, PLANTS
One of the fermented milk products, namely kefir, is increasingly popular because it has many health benefits. Peanut juice has a high enough protein content that it can be used as a substitute for animal milk. The purpose of this study was to determine the quality of peanut kefir with variations in the concentration of ragi tape inoculum and fermentation time. This research method used 3 variations in the concentration of tape yeast (1, 2 and 4%) and long fermentation time (24, 48 and 72 hours). The results showed that the highest total LAB was in 4% ragi tape inoculum with a fermentation time of 24 hours (4.4x108 cells/mL) and the lowest was in 4% tape yeast inoculum with a fermentation time of 72 hours (9.8x107 cells/mL) and total yeast between 1x104 cells/mL - 3x105 cells/mL) and alcohol produced <1%. Total acid obtained between 6% - 17.6%. The increase in total acid is proportional to the decrease in pH. The pH of the peanut kefir medium was between 3.44 - 4.12. Peanut kefir with tape yeast inoculum meets the standard requirements for fermented milk and can replace milk kefir.
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