Polyethylene glycols (PEGs) with different molecular weights (M w = 200, 400, 1000) were phosphorylated to their bis-diphenyl phosphinite derivatives as stable solids which are melted in the range 140-160 C. These phosphorylated PEGs were used as ligands and reducing agents to generate nano-Pd(0) catalysts in 2.5-8.3 nm. The nano-Pd(0) particles supported on phosphorylated PEG 200 were applied for the efficient Heck-Mizoroki carbon-carbon coupling reactions of ArX (X = Cl, Br, I) at 80-100 C under solvent-free conditions and for the Suzuki-Miyaura coupling reaction in ethanol at 70 C. The catalyst was recycled easily and reused for several runs.
In this study synthesis of a drug delivery system (DDS) is described which has several merits over its counterparts. In order to synthesize this nano-carrier, graphene oxide nano-sheets are used to accommodate MCM-41 nanoparticles. Furthermore Fe 3 O 4 nanoparticles are introduced to this nanomaterial to produce a traceable nanoparticle. Since cancerous tissues have lower pH than healthy tissues, pH-sensitive oligomers are attached to this nano-material. Finally the nano-carrier is wrapped by a biocompatible shell (PEGylated sodium alginate); this polymeric shell makes the DDS capable of a more controllable drug release. By measuring in vitro situation, 'loading content%' and 'entrapment efficiency%' proves to be 21 and 93.5 % respectively. In an acidic medium, the drug carrier without a polymeric shell (naked DDS) releases the whole of its drug content in 18 h, while the drug carrier with a polymeric shell (core-shell DDS) releases 45 % of its drug content during 48 h.
Phosphorylated PEG (PPEG) as a New Support for Generation of Nano-Pd(0): Application to the Heck-Mizoroki and Suzuki-Miyaura Coupling Reactions. -This describes new nano-Pd catalysts generated in situ from PdCl 2 and bis-diphenylphosphorylated PEGs. The catalysts are successfully applied in coupling reactions and can be easily recycled and reused at least four times without a significant loss in activity. -(IRANPOOR*, N.; FIROUZABADI, H.; RIAZI, A.; SHAKERPOOR, A.; Appl. Organomet. Chem. 27 (2013) 8, 451-458, http://dx.doi.org/10.1002/aoc.3002 ; Dep. Chem., Coll. Sci., Shiraz Univ., Shiraz 71454, Iran; Eng.) -Roessler 52-082
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.