Dendrimer-like supramolecular nanovalves based on polypseudorotaxane and mesoporous silica-coated magnetic graphene oxide: a potential pH-sensitive anticancer drug carrier

Multifunctional Peptide-Amphiphile End-Capped Mesoporous Silica Nanoparticles for Tumor Targeting Drug Delivery

“…Among a variety of DDSs, great effort has been taken for the development of porous inorganic nanoparticles, such as mesoporous silica nanoparticles (MSNs), , carbon nanotubes (CNTs), , nanographene, , and copper sulfide nanoparticles. , Biocompatible MSNs with unique properties, including large specific surface areas, high pore volumes, highly ordered channels, easy surface modification, and low toxicity, have been widely developed into a type of excellent candidates for controlled drug delivery. Currently, a variety of multifunctional MSNs have been intensively fabricated by incorporating diverse kinds of nanovalves, such as peptides, nanoparticles, polymers, and biomolecules, and utilized for encapsulating antitumor drugs into the mesopores without premature drug release under a physiological environment. ,,− However, nanovalves can be removed by some specific stimuli, such as redox potential, enzymatic activity, temperature, pH, light, magnetic actuation, and electrostatics, leading to a quick release of antitumor drugs. For example, Zhang’s group reported an envelope-type DDS based on MSNs that were end-capped with multifunctional peptide and β-cyclodextrin (β-CD) via disulfide bonds, which exhibited great potential for matrix metalloproteinase (MMP)-triggered tumor-specific targeting and glutathione-induced controlled drug release .…”

Acid and base dual-controlled cargo molecule release from polyaniline gated-hollow mesoporous silica nanoparticles

“…6 Among these nanocontainers, mesoporous silica nanoparticles (MSNs) stand out because of their easy surface modification, uniform-ordered mesoporous structure, and tunable size. 7,8 A stimuli-responsive gate was constructed on MSNs by several mechanisms, such as using dendrimers, 9 inorganic nanoparticles, 10 macrocyclic molecules, 11,12 and responsive-molecular chains to effectively encapsulate and reduce the cargo molecules' premature leakage from mesoporous silica nanoparticles. 13 Among these, molecular chains can flexibly operate the "on" or "off" of the gate.…”

Recent Advances of Graphene-based Hybrids with Magnetic Nanoparticles for Biomedical Applications

“…In a recent study, drug nanocarriers based on mesoporous silica-coated magnetic GO were synthesized for anti-cancer drug delivery of DOX [ 24 ]. The addition of mesoporous silica increases the surface area, thus drug loading, as well as the cellular uptake.…”