“…Among a variety of DDSs, great effort has been taken for the development of porous inorganic nanoparticles, such as mesoporous silica nanoparticles (MSNs), , carbon nanotubes (CNTs), , nanographene, , and copper sulfide nanoparticles. , Biocompatible MSNs with unique properties, including large specific surface areas, high pore volumes, highly ordered channels, easy surface modification, and low toxicity, have been widely developed into a type of excellent candidates for controlled drug delivery. Currently, a variety of multifunctional MSNs have been intensively fabricated by incorporating diverse kinds of nanovalves, such as peptides, nanoparticles, polymers, and biomolecules, and utilized for encapsulating antitumor drugs into the mesopores without premature drug release under a physiological environment. ,,− However, nanovalves can be removed by some specific stimuli, such as redox potential, enzymatic activity, temperature, pH, light, magnetic actuation, and electrostatics, leading to a quick release of antitumor drugs. For example, Zhang’s group reported an envelope-type DDS based on MSNs that were end-capped with multifunctional peptide and β-cyclodextrin (β-CD) via disulfide bonds, which exhibited great potential for matrix metalloproteinase (MMP)-triggered tumor-specific targeting and glutathione-induced controlled drug release .…”