Acid and base dual-controlled cargo molecule release from polyaniline gated-hollow mesoporous silica nanoparticles

Abstract

Polyaniline chains grafted onto the surface of hollow mesoporous silica served as the gate to realize drug dual-controlled release.

Polymer‐Brush‐Grafted Mesoporous Silica Nanoparticles for Triggered Drug Delivery

“…The polymer chains tend to interact preferentially with the water molecules, modulate their swelling properties gradually from neutral state to ionized state and then the loaded drug will depart from MSNs ,. Currently, a great number of MSN‐based pH‐responsive controlled release systems have been studied, especially in cancer therapy due to the significantly lower pH values in tumor tissues . In one study, poly (L‐histidine) (PLH) and poly (ethylene glycol) (PEG)‐grafted MSNs (MSNs‐PLH‐PEG) with an ‘‘on‐off” switch was designed and evaluated for tumor‐specific drug release .…”

“…Responsive polymers Synthesis References pH poly(l-histidine) graft to [7] polyaniline graft from [21] poly (acrylic acid) graft to [22] Temperature poly-N-isopropylacrylamide graft from [23] poly(epsilon-caprolactone) graft to [24] poly(ethylene glycol-lactide) graft to [25] Enzyme polyglutamic acid graft from [10] azido-GFLGR 7 RGDS graft to [26] Light azobenzene/b-cyclodextrin graft to [27] 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 controllability over the shape and length of polymers, which is essential for drug delivery and cell targeting. [38]…”

“…[41,42] Currently, a great number of MSN-based pH-responsive controlled release systems have been studied, especially in cancer therapy due to the significantly lower pH values in tumor tissues. [21] In one study, poly (L-histidine) (PLH) and poly (ethylene glycol) (PEG)-grafted MSNs (MSNs-PLH-PEG) with an ''on-off" switch was designed and evaluated for tumor-specific drug release. [7] NPs with an "off" switch first accumulated in tumor site via enhanced permeability and retention (EPR) effect, then PLH accepted proton and facilitated the endocytosis of NPs by tumor cells.…”

Hollow Mesoporous Functional Hybrid Materials: Fascinating Platforms for Advanced Applications

“…Many polymers have been used as gatekeepers on HMS nanoparticles (PEG, PEG‐chitosan, polyaniline, spiropyran‐containing light‐responsive copolymer, poly(2‐(diethylamino)ethyl methacrylate), poly(hyaluronic acid), polymeric prodrug integrated with tert ‐butoxycarbonyl protected hydrazide groups, and oligoethylene glycols). Most of these gatekeepers respond to pH, redox agents, and light.…”

“…Polyaniline‐coated HMSNs were also synthesized by in situ chemical oxidative polymerization . The HMSNs coated with a long polyaniline chain had a significantly lower DOX loading capacity due to channel blockage, whereas HMSNs grafted with oligomer polyaniline encapsulated effectively the cationic cargo molecules (rhodamine 6G and DOX) with aromatic structures and exhibited the controlled release of guest molecules under acidic conditions.…”