Magnetic graphene oxide mesoporous silica hybrid nanoparticles with dendritic pH sensitive moieties coated by PEGylated alginate-co-poly (acrylic acid) for targeted and controlled drug delivery purposes

Abstract

In this study synthesis of a drug delivery system (DDS) is described which has several merits over its counterparts. In order to synthesize this nano-carrier, graphene oxide nano-sheets are used to accommodate MCM-41 nanoparticles. Furthermore Fe 3 O 4 nanoparticles are introduced to this nanomaterial to produce a traceable nanoparticle. Since cancerous tissues have lower pH than healthy tissues, pH-sensitive oligomers are attached to this nano-material. Finally the nano-carrier is wrapped by a biocompatible shell (PEGylated sodium alginate); this polymeric shell makes the DDS capable of a more controllable drug release. By measuring in vitro situation, 'loading content%' and 'entrapment efficiency%' proves to be 21 and 93.5 % respectively. In an acidic medium, the drug carrier without a polymeric shell (naked DDS) releases the whole of its drug content in 18 h, while the drug carrier with a polymeric shell (core-shell DDS) releases 45 % of its drug content during 48 h.

Synthesis and Properties of Cefixime Core–Shell Magnetic Nano-Molecularly Imprinted Materials

“…MIPs are synthetic materials with a specific selection of target molecules [13], which, owing to their imprinted site, are complementary to the target molecules in shape and size [14,15], vividly described as artificially synthesized tailor-made polymers [16,17]. MIPs benefit from excellent properties, such as prominent selectivity, strong anti-interference ability, and convenient synthesis [18][19][20]. They have application opportunities in solid phase extraction, controlled drug release, sensors, and catalysis [21,22].…”