These findings indicate that the Leu10Pro and C-509T polymorphisms may be involved in the modulation of expression of the TGF-beta1 gene, and therefore a predisposition to peptic ulcer disease could be linked to particular alleles of this gene. In particular, a possible role of TGF-beta1 in the pathogenesis of gastric ulcer disease is discussed.
Objective of the study: to analyze and systematize the results of fundamental and clinical studies of recent years devoted to the study of the pathogenetic mechanisms of myocardial and coronary artery damage in patients who have undergone a new coronavirus infection (COVID-19). Materials and methods. The search for scientific information was carried out in domestic (E-Library) and foreign databases (PubMed, Scopus, Oxford University Press, Springer, Web of Science Core Collection). Results. It has been shown that the variety of cardiovascular system pathologies after a coronavirus infection is quite wide: heart failure, arrhythmias, sudden cardiac death, coronary heart disease, coronary microvascular dysfunction with coronary insufficiency, formation of coronary artery and aortic aneurysms, hypertension, labile heart rate and BP response to physical activity, acceleration of atherogenesis processes, venous and arterial thromboembolism. Cardiovascular pathology can develop both in patients after severe and moderate COVID-19, and in oligosymptomatic and asymptomatic individuals. Patients with emerging cardiovascular pathology in the acute period of coronavirus infection, as a rule, are under observation and in this situation changes in therapeutic strategies occur faster. Patients with newly diagnosed cardiovascular pathology after suffering COVID-19 need special attention and timely assessment to exclude or confirm cardiovascular complications. Conclusion. The presented data suggest that the tactics and strategy for the management of cardiovascular diseases in the post-covid period should be based on the timely and modern diagnosis of the onset or decompensation of cardiovascular pathology, competent, in accordance with current recommendations management of cardiovascular pathology with emphasis on the use of therapeutic interventions affecting the pathophysiological mechanisms of long covid.
The purpose of the study is to establish the relationship between the accentuation of temperament properties, clinical picture of disease, and adherence to therapy in patients with gastroesophageal reflux disease with different phenotype of oxidative metabolism. Materials and methods. To achieve this goal, a case-control study was conducted in 156 patients aged 21 to 55 years (101 men and 55 women, mean age 38 years (IQR 29-46)) with verified gastroesophageal reflux disease with assessment of the clinical picture, assessment of the severity of symptoms using a visual analogue scale, concomitant pathology, adherence to therapy, phenotype of oxidative metabolism with the eufillin marker drug, determination of personal psychophysiological features using a temperament accentuation test. Statistical analyses were performed according to study objectives and data set features. Results. In patients with gastroesophageal reflux disease, 3 main personality types were identified: hyperthymic (n = 29; 19 %), mixed (n = 61; 39 %) and emotionally unstable type (n = 66; 42 %). By oxidative metabolism phenotype, 156 patients were divided into rapid (n = 51; 33 %), intermediate (n = 82; 52 %) and slow metabolizers (n = 23; 15 %). Analysis of multinomial logistic regression showed that in patients with rapid metabolism, in contrast to intermediate and slow metabolizers, low pain syndrome intensity should be expected (p = 0.014). There was no effect on the clinical presentation of temperament properties (p = 0.063). When studying the dependence of adherence to therapy on the properties of temperament and the patient`s metabolic level by multinomial logistic regression in patients with a hyperthymic type of accentuation of temperament properties, the probability of high adherence to therapy was more than 65 % in fast and intermediate metabolizers and 100 % in slow metabolizers (p = 0.006), in patients with mixed types the probability of high adherence to therapy is observed only in slow metabolizers (p = 0.006), patients with emotionally unstable type have a high probability of low adherence to therapy regardless of metabolic level (p = 0.006). Conclusion. To predict adherence of patients with gastroesophageal reflux disease to therapy, it is advisable to determine the level of oxidative metabolism and the type of accentuation of temperament properties.
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