Our results showed significant improvement in wound size and epithelial healing after topical ozonated oil application compared to control oil on palatal wounds.

Objective: The present study was undertaken to assess the therapeutic effects of topical ozonated oil on early healing of free gingival graft surgical sites. Study Design: Twenty subjects were entered into this triple-blinded, randomized, placebo-controlled clinical trial, designed to evaluate the efficacy of ozonated oil on free gingival graft surgical wounds. Subjects were assigned to either the ozone group, in which ozonated oil was applied to the surgical wound, or the control group, in which non-ozonated oil was used as a control. Patients were postoperatively evaluated by cytological analysis. Cytological analysis consisted of the keratinisation and superficial cell indices measured at baseline, after 24 h, on the 3rd, 7th, 14th and 21st day and 2, 3, 8 and 18 months postoperatively. Results: Cytological results showed that there was a significant (p < 0.001) improvement in epithelial healing by the 7th, 14th and 21st day and 2, 3 and 8 months postoperatively in the ozone group compared to the control group. Conclusion: The present study showed significant improvement in epithelial healing and gingival health after topical application of ozone-treated plant oil to gingival surgical sites.

ObjectiveTo determine sex-based differences in risk of a second ACL injury (overall and by laterality) following primary ACL reconstruction in athletes who are attempting to return to sport.DesignSystematic review with meta-analysis.Data sourcesSystematic search of five databases conducted in August 2019.Eligibility criteria for selecting studiesStudies reporting sex-based differences in the incidence of second ACL injury in athletes attempting to return-to-sports and who were followed for at least 1 year following primary ACL reconstruction.ResultsNineteen studies were included in this review, with seven studies excluded from the primary meta-analysis due to high risk of bias. The remaining 12 studies (n=1431 females, n=1513 males) underwent meta-analysis, with all 19 studies included in a sensitivity analysis. Total second ACL injury risk was 21.9% (females: 22.8%, males: 20.3%). Females were found to have 10.7% risk of an ipsilateral ACL injury and 11.8% risk of a contralateral ACL injury. Males were found to have 12.0% risk of an ipsilateral ACL injury and 8.7% risk of a contralateral ACL injury. No statistically significant differences were observed for total second ACL injury risk (risk difference=−0.6%, 95% CI −4.9 to 3.7, p=0.783, I2=41%) or contralateral ACL injury risk (risk difference=1.9%, 95% CI −0.5% to 4.4%, p=0.113, I2=15%) between sexes. Females were found to have a 3.4% absolute risk reduction in subsequent ipsilateral ACL injury risk compared with males (risk difference=−3.4%, 95% CI −6.7% to −0.02%, p=0.037, I2=35%).ConclusionBoth sexes have >20% increased risk of experiencing a second ACL injury. Any difference in the absolute risk of either a subsequent ipsilateral or contralateral ACL injury between sexes appears to be small.RegistrationPROSPERO (CRD42020148369)

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Calcinosis cutis is an abnormal deposition of calcium in the skin or subcutaneous tissue and can be categorized into five subgroups: dystrophic, metastatic, iatrogenic, calciphylaxis, and idiopathic. 1,2 Subepidermal calcified nodules (SCN) are an uncommon form of idiopathic calcinosis cutis that typically presents on children's faces as whitish, yellow papules. 3,4 (Figure 1). They are often mistaken for verrucae or molluscum. 3,5 However, subepidermal calcified nodules are a distinct benign entity and can be treated by excision. 6,7 We present a literature review of current SCN case reports. | ME THODSA literature review was conducted on PubMed using the terminology "subepidermal calcified nodule" and "idiopathic calcinosis cutis." The search occurred on March 19, 2020, was not limited by date, and resulted in 268 journal articles. A total of 227 articles were excluded from data analysis due to the topic being unrelated to subepidermal calcified nodules (n = 219), unavailability of full text (n = 4), unavailability of article in English (n = 3), or lack of patient data (n = 2). The remaining 39 case reports and series were analyzed. The following data were extracted: age of patients, sex of patients, presence of systemic disease, location of lesion(s), maximum size of lesion(s), number of lesion(s), duration of lesion(s), symptoms, differential diagnoses, histopathological findings, and treatment(s) (Table 1). | RE SULTS | DemographicsA total of 109 patients (male = 70, female = 39) with median (IQR) age of 12 (10.8) were reported with subepidermal calcified nodules, which were confirmed by biopsy. Of these, 73 patients were pediatric (Pd), age < 18, and 16 patients were adults (Ad), age ≥ 18, and 20 patients' ages were not noted (NN). Median (IQR) age was 10.5 (9.0) and 40 (53.5) for the pediatric and adult populations, respectively. Most patients (96%; Pd = 71, Ad = 15, NN = 20) did not have any systemic diseases (Table 1).