Therapeutic effect of topical ozonated oil on the epithelial healing of palatal wound sites: a planimetrical and cytological study

Patel, Punit Vaibhav; Kumar, Veerendra; Kumar, Sheela; Gd, Vidya; Patel, Akash D

doi:10.1111/j.2041-1626.2011.00072.x

Cited by 51 publications

(73 citation statements)

References 35 publications

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“…The application of ozonated water had accelerated the wound healing in the oral cavity within the first 48 hours as compared to placebo water, resulting in an earlier epithelial wound closure after 7 days. Our study also supports the findings of Patel et al, [2,10,12] where an improved healing was found after one week of the ozone application.…”

Section: Discussionsupporting

confidence: 93%

“…Which it readily dissolves in water, it generates hydrogen peroxide and lipoperoxides, which can explain its prolonged disinfectant and stimulatory activity on ulcerated chronic wounds [4]. Moreover, the phenomenon of an improved wound healing after the ozone therapy has been related to the rapidly changing cell types and to the release of cytokines that modulate the complex healing process [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…The methodology was adopted as has been described in our previous paper [12]. Finally, the obtained morphometrical data of the pre-ozone treated lesion and the post-ozone treated lesion were compared and the difference was considered as the change in the morphological size of the lesion.…”

Section: Case Report and Methodologymentioning

confidence: 99%

“…Now-a-days, ozone gas which is dissolved in an oil base is gaining importance due to its excellent curative results, simple application, longer-term effects and non toxic nature [1][2][3][4]. In the past years, the therapeutic effect of ozonated oil was attributed to its antibacterial, antifungal, antiviral, antiparasitic, antihypoxic, analgesic and immunomodulatory effects on biological systems [1,[5][6][7][8][9][10][11][12]. In the present context of time, these empirical mechanisms of actions are supported by few published case reports and scientific studies, which restrict the application of the ozonated products in different fields of medicine and dentistry.…”

Section: Introductionmentioning

confidence: 99%

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The Morphometrical and Histopathological Changes which were Observed after Topical Ozone Therapy on an Exophytic Fibrous Gingival Lesion: A Case Report

Patel

Gujjari²

2013

JCDR

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We are presenting 2 cases where ozone therapy was used in the form of ozonated oil on an exophytic fibrous gingival lesion. A 42-years female patient was selected, who presented with a mild to moderately painful, exophytic, fibrous lesion on the upper anterior gingiva. This gingival lesion was treated with 2ml of ozonated oil, thrice daily for one week. After the ozone therapy, the postoperative outcomes were measured and analyzed. Finally, the lesion was subjected to an excisional biopsy and a histopathological evaluation. After the ozone therapy, the patient revealed that there was less pain. On examination of the lesion, an improvement was observed in the clinical sign of the inflammation and also a reduction in the surface ulceration. During the final biopsy, less bleeding was observed. The morphometrical analysis showed a reduction in the size of the lesion. The histopathological analysis showed a reduction in the collagen fibres and in the inflammatory cells in the connective tissue stroma. Topical ozone therapy provides potential benefits for the treatment of exophytic gingival lesions. The observed benefits in present case report needs to be verified in future with well-controlled clinical trials.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Case Report and Methodologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Morphometrical and Histopathological Changes which were Observed after Topical Ozone Therapy on an Exophytic Fibrous Gingival Lesion: A Case Report

Patel

Gujjari²

2013

JCDR

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“…Ozone gas dissolved in plant oils, such as olive oil, is being discussed in dentistry for its excellent antimicrobial property, without the development of drug resistance and facilitation of wound healing [26][27][28][29] . In orthodontics, clinicians tend to seek out an effective antimicrobial agent to apply prior to bracket bonding in order to prevent dental caries during fixed appliance treatment [30][31][32][33][34] .…”

Section: Volume 41 -June 2012mentioning

confidence: 99%

In vivo study of the effectiveness of ozonized olive oil gel on inhibiting enamel demineralization during orthodontic treatment

Ghobashy

Eltokhey

2012

Egyptian Orthodontic Journal

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The present study assessed the effect of ozonized olive oil gel during orthodontic treatment to inhibit demineralization around orthodontic brackets.Material and Methods: Material and Methods: Material and Methods: Material and Methods: Fourteen patient, aged 15-18 years, scheduled to have premolars extraction as a part of orthodontic treatment participated in the present study. The patients were randomly divided into 3 groups; control group (16 upper and lower premolars) and two experimental groups (20 upper and lower premolars for each). In the Control group no treatment was applied on the premolars. In experimental groups, after etching and bonding, T-loops were formed with 0.014 inch stainless steel wire and engaged on the experimental teeth. In experimental group II, ozonized olive oil gel was applied sparingly to the tooth surface with concentration of 20:25 µgm/ml. Participants were instructed to apply the ozonized olive oil gel to the buccal surface of the premolars three times daily for 8 weeks after regular oral hygiene procedures. After 8 weeks, the brackets were deboned and the premolars extracted carefully. The premolars of each group were divided into 2 equal numbers; 28 premolars prepared for elemental analyses (calcium and phosphorus) followed by scanning electron microscope investigation, and 28 premolars examined with polarized light. ANOVA test was applied followed by post hoc LSD test to compare between each 2 groups.

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Topical phenytoin effects on palatal wound healing

Doshi

McAuley

Tatakis

2020

Journal of Periodontology

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Background: The clinical benefits of autogenous soft tissue grafts are countered by donor site morbidity. The aim of this prospective split-mouth clinical trial is to assess clinical, histological and patient outcomes following topical phenytoin (PHT) treatment of experimental palatal wounds. Methods: Systemically healthy adults were recruited. One 6 mm diameter wound (posterior) and one 4 mm diameter wound (anterior), each 1-1.5 mm deep, were created on both sides of the palate. Wounds on one randomly chosen side received 10% phenytoin USP and contralateral wounds received carrier alone. Biopsies were harvested from anterior wounds (Day 1 or Day 5) and were routinely processed for histology. Posterior wounds were left undisturbed to clinically evaluate healing (using photographs and Healing Score Index) on Days 1, 5, 14, and 21. Questionnaires were used to assess patient-centered outcomes. Data analysis was performed using generalized logistic and generalized linear mixed models. Results: Twenty participants completed all visits. 30% of participants reported more pain on control side than the PHT side at Day 1 (P = 0.014). PHT treated sites were more likely to not exhibit swelling (OR = 9.35; P = 0.009) and to not experience pain on palpation (OR = 6.278; P = 0.007). PHT significantly and timedependently affected granulation tissue appearance (P = 0.004). Histologically, there were no significant differences between control and PHT, at any time point (P ≥ 0.853). Conclusions: The results of the present study, the first one to report on topical PHT as palatal wound treatment, suggest that PHT application on palatal wounds could result in improved healing outcomes. K E Y W O R D S biopsy, gingiva, phenytoin, wound healing 1 INTRODUCTION The available evidence indicates that autogenous soft tissue grafts are the most predictable and most stable long-term option for both root coverage. 1,2 and gingival augmentation. 3,4 However, autogenous soft tissue graft harvesting is accompanied by postoperative morbidity associated with the resulting palatal wounds, which leads to poorer patient experiences, at least in the short term. 5-8 Because of the morbidity and complications associated with autogenous soft tissue graft donor sites, several clinical studies have tested various post-operative protocols, such as application of hemostatic agents, 9 collagen matrix, 10 ozonated oil, 11 platelet concentrates, 12,13

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Therapeutic effect of topical ozonated oil on the epithelial healing of palatal wound sites: a planimetrical and cytological study

Abstract: Our results showed significant improvement in wound size and epithelial healing after topical ozonated oil application compared to control oil on palatal wounds.

Cited by 51 publications

References 35 publications

The Morphometrical and Histopathological Changes which were Observed after Topical Ozone Therapy on an Exophytic Fibrous Gingival Lesion: A Case Report

The Morphometrical and Histopathological Changes which were Observed after Topical Ozone Therapy on an Exophytic Fibrous Gingival Lesion: A Case Report

In vivo study of the effectiveness of ozonized olive oil gel on inhibiting enamel demineralization during orthodontic treatment

Topical phenytoin effects on palatal wound healing

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