Seseli L. is an important genus of the Apiaceae family, with a large number of aromatic species. It is used in traditional medicine extensively, but there is quite limited information on their phytochemicals and biological activities. Seseli petraeum M. Bieb. grows in Northern Anatolia, and there are no phytochemical studies on this species. In the present study, we aimed to investigate the effect of the extracts of S. petraeum on A549 lung cancer cell proliferation. For this purpose, the antiproliferative effect was determined via MTT assay, and the extracts obtained from the root of S. petraeum showed a significant inhibitory effect on cell proliferation. The hexane extract of the root exhibited potent inhibition on A549 cancer cell growth at the 24 th hour with 3.432 mg/mL IC 50 value. The results also showed that the hexane extract had displayed cytotoxic effect through an arrest at the G0/G1 phase of the cell cycle and induced apoptosis as well as DNA damage of A549 cells. Consequently, this study demonstrated the antiproliferative potential of the extracts from S. petraeum, especially hexane extract from the roots. Further studies are required to identify the mechanisms underlying these effects.
INTRODUCTION: In the present study, the antioxidant potency of ethyl acetate (AcOEt) and methanol (MeOH) extracts from aerial parts of Seseli L. species have been investigated for the first time. METHODS: The Seseli species L. such as Seseli andronakii Woronow ex Schischk., S.
Most of the medicinal plants possess interesting antioxidant properties. The present study aimed to evaluate the antioxidant capacity of some medicinal plants from Turkey, such as Anthemis tinctoria L. (Compositae), Inula britannica L. (Compositae), Malabaila secacul Banks & Sol (Apiaceae), Zosima absinthifolia (Vent) Link (Apiaceae), Thymus sipyleus Boiss. (Lamiaceae), Phlomis armeniaca Willd. (Lamiaceae), Sideritis galatica Bornm. (Lamiaceae), Sedum acre L. (Crassulaceae), Potentilla erecta Uspenski ex Ledeb. (Rosaceae), Digitalis lamarckii Ivan (Scrophulariaceae), Glaucium grandiflorum Boiss. & Huet var. grandiflorum (Papaveraceae), Fumaria asepala Boiss. (Papaveraceae), Centranthus longiflorus Stev. (Valerianaceae), Allium rotundum L. (Amaryllidaceae). The ethyl acetate and methanol extracts of the 14 species were screened by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, superoxide anion (SO) radical scavenging, and lipid peroxidation (LPO) assays. The methanol and ethyl acetate extracts of Potentilla erecta have the highest DPPH scavenging activity (IC50=0.014 and 0.03 mg/mL, respectively). The maximum inhibition of LPO has been exhibited by ethyl acetate extract of Glaucium grandiflorum var. grandiflorum (IC50=0.34 mg/mL) followed by methanol extracts of T. sipyleus (IC50=0.38 mg/mL). The methanol extract of A. rotundum demonstrated the highest SO activity (IC50=0.11 mg/mL). In conclusion, these extracts have a high potential for antioxidant activity may be considered to use free radical-related diseases.
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