Evaluation of the Antioxidant Potency of &lt;i&gt;Seseli&lt;/i&gt; L. Species (Apiaceae)

Önder, Alev; Çınar, Ahsen Sevde; Sarıaltın, Sezen Yılmaz; Izgi, Mehmet Necat; Çoban, Tülay

doi:10.4274/tjps.galenos.2019.80488

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…Seseli is an important genus with a high number of aromatic species used as traditional medicine due to their richness in coumarins, terpenoids, and essential oils. They have many important pharmacological activities such as reduction of inflammation, swelling, rheumatism, pain, and minimization of the common cold’s symptoms [ 22 – 24 ]. Five Seseli taxa ( S. mairei H. Wolff, S. mairei var.…”

Section: Introductionmentioning

confidence: 99%

The phylogeny of Seseli (Apiaceae, Apioideae): insights from molecular and morphological data

et al. 2022

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Background The genus Seseli L., which consists of 125–140 species distributed in the Old World from western Europe and northwestern Africa to China and Japan, is one of the largest and most taxonomically difficult genera of Apiaceae Lindl. Although several previous studies have been conducted on Seseli based on limited morphological characteristics and molecular fragments, a robust and comprehensive phylogeny of Seseli remains elusive. Plastomes provide abundant genetic information and have been widely used in studying plant phylogeny and evolution. Consequently, we newly generated the complete plastomes of eleven Seseli taxa. We combined plastome data and morphological characteristics to investigate the phylogeny of Seseli. Results In our study, we observed that the genome length, gene numbers, IR/SC borders, and repeat composition of the eleven Seseli plastomes were variable. Several appropriate mutation hotspot regions may be developed as candidate DNA barcodes for evolution, phylogeny, and species identification of Seseli. The phylogenetic results identified that Seseli was not a monophyletic group. Moreover, the eleven newly sequenced Seseli taxa did not cluster with S. tortuosum (the type species of Seseli, belonging to the tribe Selineae), where S. delavayi clustered with Eriocycla belonging to the tribe Echinophoreae and the other ten belonged to Selineae. The comparative plastome and morphological characteristics analyses confirmed the reliability of the phylogenetic analyses and implied the complex evolution of Seseli. Conclusion Combining molecular and morphological data is efficient and useful for studying the phylogeny of Seseli. We suggest that “a narrow sense” of Seseli will be meaningful for further study and the current taxonomic system of Seseli needs to be revised. In summary, our study can provide new insights into the phylogenetic relationships and taxonomic framework of Seseli.

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Section: Introductionmentioning

confidence: 99%

The phylogeny of Seseli (Apiaceae, Apioideae): insights from molecular and morphological data

et al. 2022

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“…Several Seseli species have been previously validated for their antioxidant capacity. In the study of Önder, et al [44], the radical scavenging activity and anti-lipid peroxidation of the ethyl acetate and methanolic extracts obtained from several Seseli species growing in Turkey namely, S. andronakii, S. campestre, S. corymbosum, S. gummiferum subsp. gummiferum, S. hartvigii, S. libanotis, S. petraeum, S. arenarium, S. resinosum, and S. tortuosum were evaluated (in DPPH assay: IC 50 = 0.086-4.27 mg/mL; in lipid peroxidation assay: % inhibition of 43-95% at 5 mg/mL).…”

Section: Resultsmentioning

confidence: 99%

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

et al. 2021

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Seseli L. is one of the largest genera of the Apiaceae family widely known for their traditional uses as herbal remedies. In the present study, the methanolic and water extracts of two Seseli species, S. gummiferum and S. transcaucasicum were evaluated for their bioactive contents and biological activities. The total phenolic and flavonoid contents in the extracts ranged from 19.09 to 24.33 mg GAE/g and from 0.45 to10.09 mg RE/g, respectively. Moreover, while narcissin was detected as the most abundant component in the methanolic extract of S. transcaucasicum (261.40 µg/g), chlorogenic acid was identified as the major component in all the other extracts, although a high amount was also present in the methanolic S. transcaucasicum extract (107.48–243.12 µg/g). The total antioxidant capacity was also determined by the phosphomolybdenum assay (0.66–1.18 mM TE/g). Other antioxidant assays such as the radical scavenging assays (DPPH: 5.51–11.45 mg TE/g; ABTS: 43.46–51.91 mg TE/g), reducing assays (CUPRAC: 41.67–53.20 mg TE/g; FRAP: 31.26–34.14 mg TE/g), as well as the metal chelating activity assay (14.38–38.57 mg EDTAE/g) were conducted. All the extracts showed inhibitory potential against the enzyme’s amylase (0.12–0.78 mM ACAE/g), acetyl- and butyryl-cholinesterase (0.15–9.71 mg GALAE/g), while only the methanolic extracts acted as inhibitors of tyrosinase (107.15 and 109.37 mg KAE/g) and only the water extract of S. gummiferum displayed anti-glucosidase activity (0.13 mM ACAE/g). Interestingly, the methanolic extracts of both Seseli species showed lower cytotoxicity towards HaCaT cells (IC50: >500 µg/mL), compared to the water extracts (IC50: 267.8 and 321.41 µg/mL). Besides, only the methanolic extracts showed a slight wound healing effect (28.21 and 31.23%). All extracts showed antibacterial action against Staphylococcus lugdunensis (minimum inhibitory and bactericidal concentrations: 0.025–2 mg/mL). S. gummiferum methanolic extract, which exhibited the highest antibacterial potency was found to inhibit adhesion and invasion of S. lugdunensis to HaCaT cells as well. Taken together, this study demonstrated the two Seseli species to harbour interesting bioactive components, in particular polyphenolics and to exhibit several biological properties that could be further investigated for their potential exploitation as healing agents as supported by various traditional medicinal uses.

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“…The antioxidant capacity of the Apiaceae family (Umbelliferae) has been extensively studied, showing very promising potential [ 14 , 15 , 16 ]. Ammi visnaga L. ( Daucus visnaga L., Visnaga daucoides Gaertn.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antioxidant Activity of Ammi visnaga L. Essential Oil

et al. 2022

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The present study evaluated the chemical composition and the in vitro and in vivo antioxidant potential of Ammi visnaga L. essential oil to provide a scientific basis for the use of this plant in the traditional pharmacopoeia. Gas chromatography-mass spectrometry was used to identify the volatile constituents present of the oil. The in vitro antioxidant capacity was evaluated by the DPPH and the reducing power assays. For the in vivo tests, oral administration of Ammi visnaga L. oil (600 and 1200 mg/kg body weight) was performed in Swiss albino mice treated with acetaminophen (400 mg/kg). The toxic effect of acetaminophen and the action of the essential oil were measured by determining the levels of lipid peroxidation and antioxidant enzymes in liver and kidneys homogenates. The major components identified were butanoic acid, 2-methyl-, pentyl ester, (Z)-β-ocimene, D-limonene, linalool, pulegone and lavandulyl-butyrate. The in vitro DPPH and reducing power assays showed moderate to low free radical scavenging activity and the antioxidant power was positively correlated with the polyphenols’ concentration. In vivo, the Ammi visnaga L. essential oil showed a high antioxidant capacity at both concentrations (600 and 1200 mg/kg), effectively increasing the levels of reduced glutathione, superoxide dismutase, and catalase and significantly reducing the lipid peroxidation. The results obtained from this study suggest that Ammi visnaga L. could represent a source of molecules with antioxidant potential in the prevention of free radical-related diseases.

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Evaluation of the Antioxidant Potency of <i>Seseli</i> L. Species (Apiaceae)

Cited by 10 publications

References 23 publications

The phylogeny of Seseli (Apiaceae, Apioideae): insights from molecular and morphological data

The phylogeny of Seseli (Apiaceae, Apioideae): insights from molecular and morphological data

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

Chemical Composition and Antioxidant Activity of Ammi visnaga L. Essential Oil

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