The characterization of phenolic compounds via LC-ESI-MS/MS, antioxidant, enzyme inhibitory activities of Salvia absconditiflora, Salvia sclarea, and Salvia palaestina: A comparative analysis

Önder, Alev; Izgi, Mehmet Necat; Çınar, Ahsen Sevde; Zengin, Gökhan; Yılmaz, Mustafa Abdullah

doi:10.1016/j.sajb.2022.07.030

Cited by 13 publications

(9 citation statements)

References 43 publications

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“…Tohma et al [ 44 ] also studied the antioxidant properties of S. aethiopis in DPPH, FRAP, and cupric-ion-reducing antioxidant (CUPRAC) assays. Extracts from S. sclarea were shown to scavenge DPPH (85.08 mg TE/g) and ABTS (33 mg TE/g) radicals, reduce ferric (77.06 mg TE/g) and cupric (144.75 mg TE/g) ions, and chelate ferrous ions (37.27 mg EDTAE/g) [ 57 ]. The antioxidant effects of other Salvia species (e.g., S. blepharochlaena , S. euphratica var.…”

Section: Resultsmentioning

confidence: 99%

Chemical Profile and Bioactivity Evaluation of Salvia Species from Eastern Europe

et al. 2023

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The Salvia genus comprises about 1000 species endowed with medicinal, aromatic, cosmetic, and ornamental applications. Even though the genus is one of the most-studied taxa of the Lamiaceae family, data on the chemical composition and biological properties of certain locally used Salvia species are still scarce. The present work aimed to evaluate the phytochemical profile and antimicrobial, antioxidant, and cytotoxic potential of ten Salvia species that grow in Eastern Europe (e.g., the Republic of Moldova). LC-HRMS/MS metabolite profiling allowed for the annotation of 15 phenolic and organic acids, 18 flavonoids, 19 diterpenes, 5 sesterpenes, and 2 triterpenes. Multivariate analysis (e.g., principal component analysis, hierarchical cluster analysis) revealed that S. austriaca, S. nutans, and S. officinalis formed individual clusters, whereas the remaining species had a similar composition. S. officinalis showed the highest activity against Staphylococcus aureus and Streptococcus pneumoniae (MIC = 0.625 mg/mL). As evaluated in DPPH, ABTS, and FRAP assays, S. officinalis was one of the most potent radical scavenging and metal-reducing agents (CE50 values of 25.33, 8.13, and 21.01 μg/mL, respectively), followed by S. verticillata, S. sclarea, S. kopetdaghensis, S. aethiopis, and S. tesquicola. Pearson correlation analysis revealed strong correlations with rosmarinic acid, luteolin-O-glucuronide, and hydroxybenzoic acid. When the cytotoxic activity was evaluated in human breast carcinoma MCF-7 and MDA-MB-231 cells, no significant reduction in cell viability was observed over the concentrations ranging from 25 and 100 μg/mL. The results confirm the potential use of understudied Salvia species as promising sources of antioxidant compounds for developing novel pharmaceutical, nutraceutical, or cosmeceutical products.

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Section: Resultsmentioning

confidence: 99%

Chemical Profile and Bioactivity Evaluation of Salvia Species from Eastern Europe

et al. 2023

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“…The quantification of the total phenolic and flavonoid contents was conducted through the utilization of the Folin-Ciocalteu and AlCl 3 assays, correspondingly. [57,58] The outcomes were denoted in terms of gallic acid (mg GAEs/g extract) and rutin equivalents (mg REs/g extract) for their respective analyses.…”

Section: Total Phenolic and Flavonoid Contentsmentioning

confidence: 99%

Detailed Phytochemical Evaluation of a Locally Endemic Species (Campanula baskilensis) by LC‐MS/MS and Its In‐Depth Antioxidant and Enzyme Inhibitory Activities

Yilmaz,

Cakir,

Izol

et al. 2023

Chemistry & Biodiversity

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The importance of bioactive plant species in the scientific world is increasing day by day. The relationship between health and traditional‐modern life, promotes the creation of new value‐added natural products. This is the first research to conduct a bioactivity and chemical composition analysis of Campanula baskilensis species, which belongs to the medicinally important genus Campanula L (Campanulaceae). The aim of the current study is to quantitatively investigate the phytochemical contents of aerial and root parts of different C. baskilensis extracts (ethanol, methanol, and water) by LC‐MS/MS and to evaluate their total phenolic and flavonoid contents, antioxidant and enzyme inhibitory activities. Remarkably, LC‐MS/MS results revealed that, high amounts of quinic acid (53.6 mg/g aerial‐MeOH extract), fumaric acid (6.3 mg/g aerial‐H2O extract, 2.5 mg/g root‐ H2O extract), protocatechuic acid (11.4 mg/g aerial‐H2O extract), vanilic acid (1.4 mg/g aerial‐EtOH extract), quercetin‐3‐O‐rutinoside (rutin) (2.3 mg/g aerial‐EtOH extract), hesperetin 7‐rutinoside (hesperidin) (2.0 mg/g aerial‐EtOH extract), kaempferol‐3‐O‐rutinoside (nicotiflorin) (5.5 mg/g aerial‐EtOH extract) were detected in the extracts of the species. Considering the bioactivity tests performed on C. baskilensis extracts, aerial‐H2O extract showed significant activity in all antioxidant assays. However, ethanol extracts of root and aerial parts exhibited the highest activities in all enzyme inhibitory tests.

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“…[3] Türkiye is the host of many different kinds of plants because of having different geographical regions. [4] There are more than ten thousand plant taxa in Türkiye and about four thousand of them are endemic. [5] Species of the genus Verbascum spread wild to many parts of Eurasia.…”

Section: Introductionmentioning

confidence: 99%

“…Studies reporting the biological activities of the plant extracts serve as a reference for the discovery of plants with therapeutic potential for many diseases [3] . Türkiye is the host of many different kinds of plants because of having different geographical regions [4] . There are more than ten thousand plant taxa in Türkiye and about four thousand of them are endemic [5] .…”

Section: Introductionmentioning

confidence: 99%

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Ferruginoside D: A Novel Phenylethanoid from Verbascum leiocarpum

Şimşek,

Akşit,

Aydın

et al. 2023

Chemistry & Biodiversity

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A novel phenylethanoid, ferruginoside D, together with fourteen known compounds were isolated from the Verbascum leiocarpum for the first time. Chemical structures of isolated compounds were determined by spectroscopic analysis including HR‐ESI‐MS and NMR spectra. The antioxidant, α‐glucosidase inhibitory properties, and antiproliferative activities against multiple cell lines (A172, C6, HeLa, A2780, SW620, HT29, Beas2B, RPE, and HSF) of the isolated compounds were evaluated in vitro. According to the results, iridoids, flavonoids (luteolin and apigenin), and phenylethanoids (poliumoside and isoverbascoside) with strong antiproliferative potential were also found to have cytostatic effects. Furthermore, the investigation revealed that compounds luteolin, poliumoside, verbascoside, isoverbascoside, ferruginoside C, ferruginoside D, and ursolic acid show potent alpha‐glucosidase inhibitory activity, while compounds luteolin, verbascoside, and isoverbascoside exhibit substantial antioxidant activity. The new compound (ferruginoside D) was found moderately active against cancer cell lines, with strong alpha‐glucosidase inhibitory activity, and moderate antioxidant properties.

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The characterization of phenolic compounds via LC-ESI-MS/MS, antioxidant, enzyme inhibitory activities of Salvia absconditiflora, Salvia sclarea, and Salvia palaestina: A comparative analysis

Cited by 13 publications

References 43 publications

Chemical Profile and Bioactivity Evaluation of Salvia Species from Eastern Europe

Chemical Profile and Bioactivity Evaluation of Salvia Species from Eastern Europe

Detailed Phytochemical Evaluation of a Locally Endemic Species (Campanula baskilensis) by LC‐MS/MS and Its In‐Depth Antioxidant and Enzyme Inhibitory Activities

Ferruginoside D: A Novel Phenylethanoid from Verbascum leiocarpum

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