Coumarins from Seseli petraeum M. Bieb. (Apiaceae) and their α-glucosidase inhibitory activity

Önder, Alev; Çınar, Ahsen Sevde; Baran, Merve Yüzbaşıoğlu; Kuruüzüm-Uz, Ayşe; Трендафилова, Антоанета

doi:10.1016/j.sajb.2021.09.022

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…Several coumarins were tested for their inhibitory activity against α-amylase and α-glycosidase, and were found to show prominent inhibitory activity against α-glycosidase and a low inhibitory potential against α-amylase. Octanoyllomatin was the best inhibitor of a-glycosidase (IC50 = 69.00 ± 0.43 µg/mL) [61].…”

Section: Other Activitiesmentioning

confidence: 94%

Plant Pyranocoumarins: Description, Biosynthesis, Application

Ханды

Sofronova

Gorpenchenko

et al. 2022

Plants

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This overview article contains information about pyranocoumarins over the last 55 years. The article is based on the authors’ phytochemical and physiological studies in vivo and in vitro as well as search and analysis of data in literature available on Google Scholar, Web of Science, PubMed, and ScienceDirect before January 2022. Pyranocoumarins are synthesized in plants of the Apiaceae, Rutaceae families, and one species in each of the Cornaceae, Calophyllaceae, and Fabaceae families can synthesize this class of compounds. The physiological role of these compounds in plants is not clear. It has been proven that these substances have a wide range of biological activities: anti-cancer, anti-spasmatic, and anticoagulant, and they also inhibit erythrocyte lysis and accumulation of triacylglycerides. The overview generalizes the modern understanding of the classification, structure, and biological activity of natural pyranocoumarins, and summarizes dispersed data into a unified scheme of biosynthesis. The review analyzes data on the localization and productivity of these substances in individual organs and the whole plant. It discusses a link between the unique structure of these substances and their biological activity, as well as new opportunities for pyranocoumarins in pharmacology. The article evaluates the potential of different plant species as producers of pyranocoumarins and considers the possibilities of cell cultures to obtain the end product.

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Section: Other Activitiesmentioning

confidence: 94%

Plant Pyranocoumarins: Description, Biosynthesis, Application

Ханды

Sofronova

Gorpenchenko

et al. 2022

Plants

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“…The results unveiled notable and significant inhibitory effects [28] . Similarly, a coumarin called octanoyllomatin isolated from the hexane extract of Seseli petraeum exhibited significant inhibition of the α ‐glucosidase enzyme [29] . Additionally, a hexane extract from Ferula haussknechtii flowers showed significant inhibitory effects on α ‐glucosidase activity [30]…”

Section: Resultsmentioning

confidence: 99%

Exploring Astrodaucus orientalis (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes

Yuca,

Aydin,

Karakaya

et al. 2024

Chemistry & Biodiversity

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In current study antioxidant, antidiabetic, antimicrobial, anticholinesterase, and human carbonic anhydrase I, and II (hCA I and II) isoenzymes inhibition activities of Astrodaucus orientalis different parts were investigated. Achetylcholinesterse (AChE) and butyrylcholinesterse (BChE) inhibitory activities of octyl acetate were determined via molecular docking. Quantitative assessment of specific secondary metabolites was conducted using LC‐MS/MS. An examination of chemical composition of essential oils was carried out by GC‐MS/MS. A thorough exploration of plant's anatomical characteristics was undertaken. The highest phenolics level and DPPH antioxidant capacity were seen in root and fruit. Fruit essential oil demonstrated the highest AChE inhibition (44.13±3.61%), while root dichloromethane sub‐extract had the best inhibition towards BChE (86.13±2.58%). Cytosolic hCA I, and II isoenzymes were influentially inhibited by root oil with 1.974 and 2.207 µM IC50 values, respectively. The most effective extracts were found to be root all extract/sub‐extracts (except water) against C. tropicalis and C. krusei strains with MIC value 160> µg/mL. Sabinene (29.4%), α‐pinene (20.2%); octyl acetate (54.3%); myrcene (28.0%); octyl octanoate (71.3%) were found principal components of aerial parts, roots, flowers, and fruits, respectively. Flower essential oil, fruit dicloromethane and ethyl acetate exhibited potent α‐glucosidase inhibitory activity with 900, 40, and 937 µg/mL IC50 values, respectively.

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“…In this context, there is a necessity to explore and develop new natural antidiabetic candidates. Previous records indicated the therapeutic effects of coumarins and their derivatives on diabetes; fraxetin significantly decreased BGL as well as glycosylated hemoglobin and increased the plasma insulin level at a dose of 80 mg/kg body weight [ 36 ] and octanoyllomatin exhibited a prominent α-glucosidase inhibition with IC50 value (69 µg/mL) [ 37 ]. Further examples include peucedanol glucoside, which showed a 39% reduction in postprandial hyperglycemia at a dose of 5.8 mg/kg [ 38 ], and umbelliferone, which revealed a notable antihyperglycemic effect comparable to GB at a dose of 30 mg/kg body weight [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanistic Insights into the Ameliorative Effect of Cichoriin on Diabetic Rats—Assisted with an In Silico Approach

et al. 2022

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Type 2 diabetes mellitus is considered to be a substantial socioeconomic burden worldwide on both patients and governments. Coumarins are biomolecules with a diversity of biological activities. The current investigation aimed to explore the ameliorative effects of cichoriin, which is a type of coumarin, on high-fat diet/streptozotocin (HFD/STZ)-induced diabetic rats. Methods: Rats were allocated into five groups. Group I was considered as the control group, while the other groups were HFD/STZ-induced diabetic rats. Group II was assigned as the diabetic control. Groups III and IV were treated with cichoriin (50 or 100 mg/kg, respectively). Group V received glibenclamide (5 mg/kg) (as a positive control). The blood glucose (BG), serum insulin, triglycerides (TG), total cholesterol (TC), total antioxidant capacity (TAC), catalase, hepatic superoxide dismutase (SOD) and content of malondialdehyde (MDA) were assessed. Histopathological and immunohistochemistry analysis of pancreatic tissue were performed. mRNA and protein expressions of GLUT4, AMPK, and PI3K were estimated. Results: Cichoriin treatment ameliorated HFD/STZ-induced diabetic conditions and mitigated the histopathological characteristics of the pancreas, as well as increasing pancreatic insulin expression. This decreased the levels of BG, TG, TC, and MDA and improved the TAC, catalase and SOD contents. Cichoriin demonstrated upregulation of mRNA and protein expressions of GLUT4, AMPK, and PI3K. The in silico binding of cichoriin with GLUT4, AMPK, and PI3K supported the possible current activities. Conclusion: Collectively, this work highlighted the potential role of cichoriin in mitigating HFD/STZ-induced diabetic conditions and showed it to be a valuable product.

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Coumarins from Seseli petraeum M. Bieb. (Apiaceae) and their α-glucosidase inhibitory activity

Cited by 8 publications

References 24 publications

Plant Pyranocoumarins: Description, Biosynthesis, Application

Plant Pyranocoumarins: Description, Biosynthesis, Application

Exploring Astrodaucus orientalis (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes

Mechanistic Insights into the Ameliorative Effect of Cichoriin on Diabetic Rats—Assisted with an In Silico Approach

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