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The authors have indicated no significant interest with commercial supporters.S kin needling or percutaneous collagen induction (PCI) suing a dermal rolling device (a needling tool) is an office procedure used for managing postacne scars. The treatment of postvaricella scars and postacne scars usually requires multiple sessions. We would hereby like to report the undesirable effect of "tram tracking" with the use of this microneedling technique.

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A rapid and sensitive RP-HPLC method with UV detection (262 nm) for routine analysis of adefovir dipivoxil in bulk and in pharmaceutical formulation was developed. Chromatography was performed with mobile phase containing a mixture of acetonitrile and phosphate buffer (50:50, v/v) with flow rate 1.0 mL min-l. In the range of 5.0-100 µg/mL, the linearity of adefovir dipivoxil shows a correlation co-efficient of 0.9999. The proposed method was validated by determining sensitivity accuracy, precision, robustness stability, specificity, selectivity and system suitability parameters.

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334 Photopiethysmography and laser Doppler flowmetryInstrumental methods for indirectly quantifying erythema include blood plethysmography and blood flow measure-

Importance of the global collaboration for the sake of regional development is very well understood by the rising economic structure of China as it has played a very important role in developing such initiates such as Belt and Road Initiative for regional advancement in Middle Eastern countries. The importance of One Belt One road initiative for the economic, cultural, and regional development cannot be overemphasized and thus it is going to bridge the gap between China and Middle Eastern countries. This research is focused on those specific requisite areas, which need a systematic scenario for the implementation of this global progressive initiative. Moreover, this research also exploits the relationship between imperative areas. Although these highlighted associations do not play a stand‐alone role, though they are and will be affected by other prompting factors. The major findings of this research study expose the dependency and mutual exclusion of these factors such as the significant change in our main variable (IPR Paradigm) due to change in Trademark, IPR institution, ownership, and confidentiality adoption because of the Sig. value is 0.014, 0.015, 0.003, and 0.002 respectively, which is less than the acceptable value of 0.05. With a 1% increase in the adoption of trademark, IPR institution, ownership, and confidentiality, the IPR Paradigm will increase by 0.183%, 0.173%, 0.197%, and 0.197% (B value) respectively.