The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position
and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were
highly active against human cytomegalovirus with a therapeutic index superior to 150. These
compounds also showed pronounced activity against varicella-zoster virus. Their structure−activity relationship is discussed.
The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.
Synthesis and Antiviral Activity of 3-Substituted Imidazo(1,2-a) pyridines.-The title compounds, e.g. (VII), are synthesized as potential antiviral agents. (VII) shows activity against both TK+ and TK-strains of varicella-zoster virus. -(ELHAKMAOUI, A.; GUEIFFIER, A.; MILHAVET, J.-C.; BLACHE, Y.; CHAPAT, J.-P.; CHAVIGNON, O.; TEULADE, J.-C.; SNOECK, R.; ANDREI, G.; DE CLERCQ, E.; Bioorg. Med.
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