A Facile Synthesis of New 3-Substituted-2,3- dihydropyrido[3,2-d]pyrimidine-2,4-diones

A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

“…Due to the wide range of biological activities of six-membered heterocyles, such as pyridinones [93] , [94] , [95] , [96] , [97] , [98] , pyridopyrimidine and other compounds, [99] , [100] , [101] , [102] , [103] , [104] , [105] , [106] , [107] , [108] , [109] several studies aiming to develop urease inhibitors based on these structural motifs have been reported. Rauf et al [110] evaluated the urease inhibitory activity of pyridopyrimidine derivatives.…”

Efficient Access to Novel Mono- and Disubstituted Pyrido[3,2-d]pyrimidines

“…First we developed an original synthesis of the 2,4-dichloropyrido [3,2-d]pyrimidine (6) with a high yield from a commercially 2,3-pyridinedicarboxylic anhydride (1, Scheme 1). 9,10 The first step consisted in a methanolysis, carried out in refluxing MeOH to afford, after recrystallization in a small amount of EtOAc, the pure regioisomer 2 in a 72% yield. 11 A further multistep sequence led to the isocyanate 3 from compound 2.…”