A Facile Synthesis of New 3‐Substituted‐2,3‐dihydropyrido[3,2‐d]pyrimidine‐2,4‐diones.

Abstract

Fused pyrimidine derivativesFused pyrimidine derivatives R 0515 A Facile Synthesis of New 3-Substituted-2,3-dihydropyrido[3,2-d]pyrimidine-2,4-diones. -Two efficient routes for the synthesis of the title compounds (IV) starting from inexpensive 2,3-pyridinedicarboxylic acid monoester (I) are reported. The first method involves the heterocyclization of urea derivatives (V) derived from isocyanate (II), the second and more efficient route uses direct condensation of the isocyanate (II) with different arylalkylamines. -(MAMOUNI, R.; AKSSIRA*, M.; AADIL, M.; ELHAKMAOUI, A.; LASRI, J.; ZABALLOS-GARCIA, E.; Synth.

Synthesis, characterization, and urease inhibition of 5-substituted-8-methyl-2H-pyrido[1,2-a]pyrimidine-2,4(3H)-diones

“…Pyridopyrimidine has wide range of biological activity, particularly in cancer and virus research (Berthelot, 1859;Mamouni et al, 2003;David et al, 1997). The pyridopyrimidine is of interest as inhibitor of dihydrofolate reductase (Mihailo et al, 2009) but also for its antibacterial, antifungal (Miller et al, 2009;Sayed et al, 2005), antitumor (Cockerill et al, 2001), adenosine kinase inhibitors (Gfesser et al, 2003;Cowart et al, 2001) activities and recently as excellent potent Akt1/2 Inhibitors (Wu et al, 2008).…”