A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

Rego, Yuri F.; Queiroz, Marcelo; Brito, Tiago O.; Carvalho, Priscila Pamela Trindade; Queiroz, Vagner Tebaldi de; Fátima, Ângelo de; Macedo, Fernando

doi:10.1016/j.jare.2018.05.003

Cited by 85 publications

(55 citation statements)

References 187 publications

(199 reference statements)

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“…Due to their structure with two ortho hydroxyl groups, isoflavone polyphenols become less toxic to urease only after the c-isoflavone ring is broken [122]. It should be emphasised that binding substituents with single pairs of electrons to the phenyl ring around the thiourea core and the presence of fluorine atom in phenyl groups, regardless of its position, also results in strong urease inhibition [123,124]. The findings of Zaborowska et al [110,111] and Siczek et al [101] corroborate the experiment results.…”

Section: Soil Enzymesupporting

confidence: 57%

Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

Zaborowska

Wyszkowska

Borowik

2020

IJMS

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The choice of the study objective was affected by numerous controversies and concerns around bisphenol F (BPF) and bisphenol S (BPS)—analogues of bisphenol A (BPA). The study focused on the determination and comparison of the scale of the BPA, BPF, and BPS impact on the soil microbiome and its enzymatic activity. The following parameters were determined in soil uncontaminated and contaminated with BPA, BPF, and BPS: the count of eleven groups of microorganisms, colony development (CD) index, microorganism ecophysiological diversity (EP) index, genetic diversity of bacteria and activity of dehydrogenases (Deh), urease (Ure), catalase (Cat), acid phosphatase (Pac), alkaline phosphatase (Pal), arylsulphatase (Aryl) and β-glucosidase (Glu). Bisphenols A, S and F significantly disrupted the soil homeostasis. BPF is regarded as the most toxic, followed by BPS and BPA. BPF and BPS reduced the abundance of Proteobacteria and Acidobacteria and increased that of Actinobacteria. Unique types of bacteria were identified as well as the characteristics of each bisphenol: Lysobacter, Steroidobacter, Variovorax, Mycoplana, for BPA, Caldilinea, Arthrobacter, Cellulosimicrobium and Promicromonospora for BPF and Dactylosporangium Geodermatophilus, Sphingopyxis for BPS. Considering the strength of a negative impact of bisphenols on the soil biochemical activity, they can be arranged as follows: BPS > BPF > BPA. Urease and arylsulphatase proved to be the most susceptible and dehydrogenases the least susceptible to bisphenols pressure, regardless of the study duration.

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Section: Soil Enzymesupporting

confidence: 57%

Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

Zaborowska

Wyszkowska

Borowik

2020

IJMS

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“…Several imperative review articles have critically reviewed and documented various natural, synthetic, and semi-synthetic UIs studied on various types of ureases and performed in vitro and in vivo studies. These articles have covered a wide range of chemical classes including phenolic compounds, alkaloids, terpenoids, and other synthetic molecules [46,47,48,49]. Given the potential efficacy of such substances against urease, it is valuable to highlight that the problem associated with the toxicity and instability, which were observed in many in vivo investigations, is a challenge for many researchers and pharmaceutical industries worldwide.…”

Section: Resultsmentioning

confidence: 99%

A Multi-Biochemical and In Silico Study on Anti-Enzymatic Actions of Pyroglutamic Acid against PDE-5, ACE, and Urease Using Various Analytical Techniques: Unexplored Pharmacological Properties and Cytotoxicity Evaluation

Šudomová¹,

Hassan

Khan

et al. 2019

Biomolecules

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In the current study, pyroglutamic acid (pGlu), a natural amino acid derivative, has efficiently inhibited the catalytic activities of three important enzymes, namely: Human recombinant phosphodiesterase-5A1 (PDE5A1), human angiotensin-converting enzyme (ACE), and urease. These enzymes were reported to be associated with several important clinical conditions in humans. Radioactivity-based assay, spectrophotometric-based assay, and an Electrospray Ionization-Mass Spectrometry-based method were employed to ascertain the inhibitory actions of pGlu against PDE5A1, ACE, and urease, respectively. The results unveiled that pGlu potently suppressed the activity of PDE5A1 (half-maximal inhibitory concentration; IC50 = 5.23 µM) compared with that of standard drug sildenafil citrate (IC50 = 7.14 µM). Moreover, pGlu at a concentration of 20 µg/mL was found to efficiently inhibit human ACE with 98.2% inhibition compared with that of standard captopril (99.6%; 20 µg/mL). The urease-catalyzed reaction was also remarkably inactivated by pGlu and standard acetohydroxamic acid with IC50 values of 1.8 and 3.9 µM, respectively. Remarkably, the outcome of in vitro cytotoxicity assay did not reveal any significant cytotoxic properties of pGlu against human cervical carcinoma cells and normal human fetal lung fibroblast cells. In addition to in vitro assays, molecular docking analyses were performed to corroborate the outcomes of in vitro results with predicted structure–activity relationships. In conclusion, pGlu could be presented as a natural and multifunctional agent with promising applications in the treatment of some ailments connected with the above-mentioned anti-enzymatic properties.

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“…From the results, it was found that urease inhibition activity depends on the number of aryl rings and substituents on it. As the number of aryl ring increases, the probability of π-π stacking of aryl rings with the active sites of enzyme or its side chain which contains cysteine or methionine groups also increase (Rego et al, 2018). As a result, good urease inhibition activity was shown by the synthesized triaryl triglycerides (3a-3d), compared to the monoglycerides reported by Sheikh et al, (2018).…”

Section: Discussionmentioning

confidence: 84%

New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities

Arshad

Sheikh

Kazmi

et al. 2018

Bangladesh J Pharmacol

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Four new bioactive aryl triester derivatives of glycerol and benzoic acids were synthesized. The synthetic compounds were studied for their antimicrobial and urease inhibition activities. Esterification was carried out by using carbonyldiimidazole to enhance the acyl elimination addition reaction with benzoic acid derivatives. The structure of triglycerides were studied by EI-MS, 1H, 13C-NMR, FT-IR and elemental analysis. All synthetic compounds showed urease inhibition activity with highest value of IC50 value 22.4 ± 0.45 μM which is nearest to standard thiourea IC50 value (21.6 ± 0.12 μM). Except compound (3d), all other compounds exhibited antimicrobial activity against Streptococcus pneumoniae, Staphylococcus epidermidis, Bacillus pumilus, Escherichia coli, Pseudomonas aeruginosa and Candida albican.Video Clip of Methodology:7 min 59 sec <a href="https://youtube.com/v/PvGTYUxO7-4">Full Screen</a> <a href="https://youtube.com/watch?v=PvGTYUxO7-4">Alternate</a>

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A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

Abstract: Graphical abstract

Cited by 85 publications

References 187 publications

Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

Soil Microbiome Response to Contamination with Bisphenol A, Bisphenol F and Bisphenol S

A Multi-Biochemical and In Silico Study on Anti-Enzymatic Actions of Pyroglutamic Acid against PDE-5, ACE, and Urease Using Various Analytical Techniques: Unexplored Pharmacological Properties and Cytotoxicity Evaluation

New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities

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