In this paper, we report the results of heterocyclizations in the pyrido[2,3‐b]pyrazine series to give the pyrido[2,3‐e] or [3,2‐e]pyrrolo[1,2‐a]pyrazine. The Clauson‐Kaas reaction on 2,3‐diaminopyridine is investigated; regioselectivity on the 3‐amino group is shown by 1H‐ and 13C‐nmr. Synthesis and reactivity of the original pyrazino[2,3‐g]indolizine series is also reported.
Synthesis and Antiviral Activity of 3-Substituted Imidazo(1,2-a) pyridines.-The title compounds, e.g. (VII), are synthesized as potential antiviral agents. (VII) shows activity against both TK+ and TK-strains of varicella-zoster virus. -(ELHAKMAOUI, A.; GUEIFFIER, A.; MILHAVET, J.-C.; BLACHE, Y.; CHAPAT, J.-P.; CHAVIGNON, O.; TEULADE, J.-C.; SNOECK, R.; ANDREI, G.; DE CLERCQ, E.; Bioorg. Med.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.