Synthesis and Antiviral Activity of 2 and 3-Substituted Imidazo[1,2-a]pyrimidine

Gueiffier, Alain; Blache, Yves; Chapat, Jean‐Pierre; Elhakmaoui, Ahmed; Essassi, E. M.; Andrei, Gracíela; Snoeck, Robert; Clercq, Erik De; Chavignon, Olivier; Teulade, Jean‐Claude; Fauvelle, F.

doi:10.1080/15257779508012425

Cited by 20 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Imidazo [1,2-a]pyrimidines are significant compounds in pharmaceutical chemistry [1][2][3]. Among them, benzimidazo [1,2-a]pyrimidinone and its derivatives have attracted considerable attention due to their various biological activities [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Catalyst-free tandem Michael addition-cyclization reactions in aqueous media for the synthesis of benzimidazo[1,2-a]pyrimidinone derivatives

Ren

Wang

et al. 2010

Sci. China Chem.

View full text Add to dashboard Cite

The catalyst-free reactions of Baylis-Hillman alcohols (1a-i) with 2-aminobenzimidazole (2) in THF-H 2 O (1:4) were developed for the convenient and greener synthesis of benzimidazo[1,2-a]pyrimidinone derivatives (3a-i). The pesticidal activities of 3a-i were examined to investigate a new biological activity of the imidazo[1,2-a]pyrimidinone-type compounds.aqueous media, Baylis-Hillman alcohol, 2-aminobenzimidazole, pesticidal activity

show abstract

Section: Introductionmentioning

confidence: 99%

Catalyst-free tandem Michael addition-cyclization reactions in aqueous media for the synthesis of benzimidazo[1,2-a]pyrimidinone derivatives

Ren

Wang

et al. 2010

Sci. China Chem.

View full text Add to dashboard Cite

show abstract

“…This compound showed a marked anti-HIV-1 activity and was 20-fold less toxic for the bone marrow than azidothymidine (AZT). In addition, they showed that ethoxymethyl (E-EPU) or benzyloxymethyl (E-BPU) derivatives (7,8) were active against AZT-resistant HIV-1 strains. 3b,c In continuation of our studies on nitrogen bridgehead heterocycles, 4 we were interested in the synthesis and antiviral activity of 3-substituted imidazo[1,2-a]azine and -diazine.…”

mentioning

confidence: 98%

Synthesis of Acyclo-C-nucleosides in the Imidazo[1,2-a]pyridine and Pyrimidine Series as Antiviral Agents

et al. 1996

View full text Add to dashboard Cite

show abstract

“…More specifically, imidazo[1,2-a]pyrimidine derivatives have already been described as benzodiazepine receptor agonists, 1 as well as antiviral, 2 antitumor, 3 and antimicrobial agents, 4 and calcium-channel blockers. 5 Trifluoromethyl-substituted pyrimidines and their condensed cyclic derivatives are well known to possess great importance in the medicinal and agricultural fields.…”

mentioning

confidence: 99%

Synthesis and Characterization of Some Novel 2-(Trifluoromethyl)pyrimido[1,2-a]benzimidazoles and Pyrimido[1,2-a]benzimidazol-2H)-ones of Biological Interest

Zanatta¹,

Amaral²,

Esteves-Souza³

et al. 2006

Synthesis

View full text Add to dashboard Cite

S y n t h e s i s o f S o m e N o v e l P y r i m i d o [ 1 , 2 -a ] b e n z i m i d a z o l e sAbstract: The synthesis of some potentially active 2-(trifluoromethyl)pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-a]benzimidazol-2(1H)-ones by the cyclization of 4-alkoxyvinyl trifluoro(chloro)methyl ketones with 2-aminobenzimidazole is described. The structure of the products was assigned based on 1 H and 13 C NMR as well as 2D-NMR experiments. Some of the obtained products exhibited significant DNA-topoisomerase I inhibitory activity.

show abstract

Synthesis and Antiviral Activity of 2 and 3-Substituted Imidazo[1,2-a]pyrimidine

Cited by 20 publications

References 0 publications

Catalyst-free tandem Michael addition-cyclization reactions in aqueous media for the synthesis of benzimidazo[1,2-a]pyrimidinone derivatives

Catalyst-free tandem Michael addition-cyclization reactions in aqueous media for the synthesis of benzimidazo[1,2-a]pyrimidinone derivatives

Synthesis of Acyclo-C-nucleosides in the Imidazo[1,2-a]pyridine and Pyrimidine Series as Antiviral Agents

Synthesis and Characterization of Some Novel 2-(Trifluoromethyl)pyrimido[1,2-a]benzimidazoles and Pyrimido[1,2-a]benzimidazol-2H)-ones of Biological Interest

Contact Info

Product

Resources

About