Objectives: Oral cancer represents a health burden worldwide. Up to 90% of oral cancer cases are squamous cell carcinomas (SCC). The data on oral SCC in Yemen are lacking. The objective of this study therefore was to describe and analyze the demographic, clinical and histological characteristics of Yemeni patients with oral SCC. Study Design: In this cross-sectional study, two sets of retrospective data for Yemeni cancer patients were obtained officially by two different registries. Patients with oral SCC were included. Their ages were dichotomized using 40 and 45 years alternately as individual cut-points for young and old patients. The patients` demographic, clinical and histological characteristics were statistically analyzed. Results: There were 457 Yemenis with oral SCC; 253 patients (55.4%) were men. The overall mean age was 58.15±14.11 years. The tongue was the most affected oral sub-site accounting for 53% of the reported cases. The well and moderately differentiated oral SCC accounted for 55.5% and 25.6% of the total cases respectively. Noteworthy, 62 patients (14%) were affected by the age of ?40; this increased to 105 patients (23%) aged ?45 years. Additionally, a high proportion of oral SCC patients (62%, 283) were diagnosed at advanced tumor stages (regional extension or metastasized). The distributions of histological grades and tumor stages in young and old patients were significantly different (P=0.006 and 0.026 respectively). Conclusion: The relative frequency of oral SCC among Yemeni young people is high. Unfortunately, most of oral SCC patients in Yemen were diagnosed at advanced stage. Key words:Oral squamous cell carcinoma, Yemen, young patients, advanced stage.

Hospital-based studies have revealed very high relative frequencies of oral and pharyngeal cancers in Yemen. This study estimated the relative frequencies of oral and pharyngeal cancers among Yemeni cancer patients registered in 2007 and 2008 and determined patients' demographic and tumour characteristics. Of the registered 7515 cases, 302 (4.0%) were oral cancer and 239 (3.2%) pharyngeal cancer. Oral cancer was significantly more frequent among females while pharyngeal cancer was significantly more frequent among males. Oral cancer patients were significantly older than pharyngeal cancer patients. The tongue was the most affected oral site (53.6%) while the nasopharynx comprised 89.5% of pharyngeal cancers. The most frequent morphological type was squamous cell carcinoma (93.2%). High proportions of oral cancer (71.5%) and pharyngeal cancer (77.4%) patients were diagnosed at advanced stages. Compared with other countries in the region, oral cancer and nasopharyngeal cancer represent substantial national health burdens in Yemen. enregistrés, 302 concernaient des cancers de la cavité buccale (4,0 %) et 239 des cancers du pha rynx (3,2 %). Les cancers de la cavité buccale étaient nettement plus fréquents chez les femmes alors que les cancers du pharynx étaient beaucoup plus nombreux chez les hommes. Les patients atteints d'un cancer de la cavité buccale étaient bien plus âgés que les patients souffrant d'un cancer du pharynx. La langue était le site le plus souvent touché de la cavité buccale (53,6 %) alors que le nasopharynx était impliqué dans 89,5 % des cancers du pharynx. Le type morphologique le plus fréquent était l'épithéliome malpighien (93,2 %). Des proportions élevées de patients atteints d'un cancer de la cavité buccale (71,5 %) ou du pharynx (77,4 %) ont reçu un diagnostic à un stade avancé de la maladie. Par rapport à d'autres pays de la Région, le cancer de la cavité buccale et du nasopharynx représente une charge sanitaire importante pour le Yémen au niveau national. ‫استعادية‬ ‫دراسة‬ ‫اليمن:‬ ‫يف‬ ‫والبلعوم‬ ‫الفم‬ ‫رسطانا‬

No abstract

No abstract

Stress – related disturbances are classified among the health problems that have global interest, especially which are related to gastrointestinal system. The consequent oxidative stress is confirmed to be responsible for the development of gastric mucosal ulcers and necrosis. That is accompanied with the release of different inflammatory mediators. On the other hand, the ratio of obesity is gradually increasing in the world. It impairs the quality of life because of its associated serious complications. Vitamin E is a fat-soluble, free radicals scavenger antioxidant. It has anti-inflammatory and cell membrane-stabilizing properties. Besides, it has anti – obesity effects. The present study highlights the potential therapeutic effects of vitamin E in the treatment of stress-induced gastric ulcers in rats. Stomach injury was induced in fasted rats by cold- restraint stress (CRS) method. Vitamin E was administered orally at a dose of 100 mg/kg for 7 consecutive days. Rats were sacrificed on the 8th day. Assessment of the stomach injury was by studying body weight changes, macroscopic examinations, histological study, and determination of oxidative stress markers (MDA stomach content and SOD enzyme activity). Vitamin E administration alleviated the stomach injury degree, and caused a remarkable body weight decrease, with a statistical significance in comparison with the stressed group. Vitamin exerted good effects in reducing body weight, and healing of stress-induced gastric ulcers in rats.

It is noteworthy to examine the efficacies of vitamin E and its combination with an antagonist of histamine receptor 2 in the treatment of stress gastric ulcers. Animals were divided into 6 groups; group 1 (normal control), group 2 (Coldrestraint stress; CRS), group 3 (ranitidine 20 mg/kg), group 4 (vitamin E 100 mg/kg), group 5 (ranitidine 10 mg/kg + vitamin E 50 mg/kg ), group 6 (ranitidine 5 mg/kg + vitamin E 50 mg/kg ). Drugs were administered orally for 7 consecutive days 1 hour after induction of the gastric injury. Rats were sacrificed. The assessment of stomach damage was by body weight observation, macroscopic examinations, histological study, and determination of oxidative stress markers (MDA stomach content and SOD enzyme activity). Present findings showed that the using of vitamin E with ranitidine is dose-dependent, and more effective than using vitamin E alone in the management of stress-induced lesions. Vitamin E caused a remarkable body weight decrease.