Protective effects of vitamin D
            <sub>3</sub>
            (cholecalciferol) on vancomycin-induced oxidative nephrotoxic damage in rats

Al-Sroji, Rouba Yasser; Al-Laham, Shaza; Almandili, Ahmad

doi:10.1080/13880209.2023.2204916

Cited by 3 publications

(3 citation statements)

References 69 publications

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“…Bagheri et al [25] evaluated the reno-protective advantages of quercetin in rats with induced ischemia/reperfusion injury through the modulation of inflammatory cytokines, NF-kB, and apoptotic proteins. Respecting Vitamin D3 findings in our study, Al-Sroji et al [24] reported that active vitamin D3 lowers oxidative stress and may mitigate renal and glomerular damage. These effects might result from upregulation of the cytosolic SOD enzyme and downregulation of the expression of NADPH oxidase.…”

Section: Discussionsupporting

confidence: 73%

“…However, in their CKD model, it tended to lower the MDA level and the degree of fibrosis in the kidney. Furthermore, Al-Sroji et al [24] reported that vitamin D3 treatment prevented acute renal damage caused by lipopolysaccharide (LPS) and lowered urea and creatinine levels. Moreover, oxidative stress decreased damage of renal tissue and glomeruli damage was mitigated by active vitamin D3.…”

Section: Discussionmentioning

confidence: 99%

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Effects Of Quercetin and Vitamin D3 on Klotho Gene Expression in Relation to Neurological Functions in Chronic Kidney Disease Rat Model

Abozaid,

Abd-Alaleem,

Abd-Elsalam

et al. 2023

Zagazig University Medical Journal

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Background: Chronic kidney disease (CKD) is a gradual damage to kidneys, featured by tubular atrophy, glomerulosclerosis and interstitial fibrosis. It is associated with cognitive dysfunctions. Moreover, inflammation and oxidative stress play vital roles in pathophysiology and progression of both CKD and accompanying neurobehavioral changes. This study aimed to detect possible beneficial effects of quercetin and vitamin D on progression of CKD and its associated neurological complications and to detect their possible mechanism/s in relation to klotho gene expression in CKD rat model. Methods: Thirty adult male albino rats were allocated into 5 groups as the following: Group 1 (Control group), Group 2 (CKD group), Group 3 (CKD+ quercetin group), Group 4 (CKD+VIT D3), and Group 5 (CKD+ quercetin+ VIT D3). Kidney function tests, some inflammatory, apoptotic and oxidative stress markers, BDNF, Klotho gene expression in kidney and brain and behavioral tests were assessed for all groups.Results: There was a significant deterioration in all parameters in CKD group. However, treated groups showed a significant improvement, especially the combined treated group. These results were supported by the significant improvement in histopathological examination. Conclusion: Quercetin and vitamin D supplementation caused elevation of klotho gene expression which in turn decreases oxidative stress, fibrosis, and apoptosis. They also increase BDNF which attenuates the associated neurobehavioral complications. So, they had a prophylactic role in CKD, prevented its progression and attenuated the associated neurobehavioral complications.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Effects Of Quercetin and Vitamin D3 on Klotho Gene Expression in Relation to Neurological Functions in Chronic Kidney Disease Rat Model

Abozaid,

Abd-Alaleem,

Abd-Elsalam

et al. 2023

Zagazig University Medical Journal

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“…1,25(OH) 2 D 3 treatment reduced the biomarkers of oxidative stress (lipid hydroxides and protein carbonyls), while the expression of antioxidant enzymes (glutathione peroxidase, superoxide dismutase, and catalase) was restored to normal levels [85]. Similarly, vitamin D sufficiency and supplementation have been associated with decreased oxidative stress and increased antioxidant biomarkers in both animal models [144][145][146][147] and human studies [148][149][150][151][152] of other health conditions, including Type II Diabetes. In addition, as discussed, vitamin D helps decrease the M1 microglial population, a potent contributor to elevated nitric oxide and reactive oxygen intermediates in MS. 1,25(OH) 2 D 3 can downregulate iNOS in activated microglia in culture and in reactive astrocytes from EAE mice [35,118].…”

Section: Reducing Oxidative Stressmentioning

confidence: 98%

The Role of Vitamin D in Neuroprotection in Multiple Sclerosis: An Update

et al. 2023

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Multiple sclerosis (MS) is a complex neurological condition that involves both inflammatory demyelinating and neurodegenerative components. MS research and treatments have traditionally focused on immunomodulation, with less investigation of neuroprotection, and this holds true for the role of vitamin D in MS. Researchers have already established that vitamin D plays an anti-inflammatory role in modulating the immune system in MS. More recently, researchers have begun investigating the potential neuroprotective role of vitamin D in MS. The active form of vitamin D, 1,25(OH)2D3, has a range of neuroprotective properties, which may be important in remyelination and/or the prevention of demyelination. The most notable finding relevant to MS is that 1,25(OH)2D3 promotes stem cell proliferation and drives the differentiation of neural stem cells into oligodendrocytes, which carry out remyelination. In addition, 1,25(OH)2D3 counteracts neurodegeneration and oxidative stress by suppressing the activation of reactive astrocytes and M1 microglia. 1,25(OH)2D3 also promotes the expression of various neuroprotective factors, including neurotrophins and antioxidant enzymes. 1,25(OH)2D3 decreases blood–brain barrier permeability, reducing leukocyte recruitment into the central nervous system. These neuroprotective effects, stimulated by 1,25(OH)2D3, all enhance neuronal survival. This review summarizes and connects the current evidence supporting the vitamin D-mediated mechanisms of action for neuroprotection in MS.

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Advances in nephroprotection: the therapeutic role of selenium, silver, and gold nanoparticles in renal health

Karunakar,

Edwin,

Gopalakrishnan

et al. 2024

Int Urol Nephrol

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Protective effects of vitamin D ₃ (cholecalciferol) on vancomycin-induced oxidative nephrotoxic damage in rats

Cited by 3 publications

References 69 publications

Effects Of Quercetin and Vitamin D3 on Klotho Gene Expression in Relation to Neurological Functions in Chronic Kidney Disease Rat Model

Effects Of Quercetin and Vitamin D3 on Klotho Gene Expression in Relation to Neurological Functions in Chronic Kidney Disease Rat Model

The Role of Vitamin D in Neuroprotection in Multiple Sclerosis: An Update

Advances in nephroprotection: the therapeutic role of selenium, silver, and gold nanoparticles in renal health

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Protective effects of vitamin D 3 (cholecalciferol) on vancomycin-induced oxidative nephrotoxic damage in rats

Cited by 3 publications

References 69 publications

Effects Of Quercetin and Vitamin D3 on Klotho Gene Expression in Relation to Neurological Functions in Chronic Kidney Disease Rat Model

Effects Of Quercetin and Vitamin D3 on Klotho Gene Expression in Relation to Neurological Functions in Chronic Kidney Disease Rat Model

The Role of Vitamin D in Neuroprotection in Multiple Sclerosis: An Update

Advances in nephroprotection: the therapeutic role of selenium, silver, and gold nanoparticles in renal health

Contact Info

Product

Resources

About

Protective effects of vitamin D ₃ (cholecalciferol) on vancomycin-induced oxidative nephrotoxic damage in rats