Background:The disease of the oral cavity is quite common in the society is periodontitis. The main cause of this condition is a certain bacterial infection found in dental plaque. In general, metronidazole gel will be given as additional therapy to treat bacterial colonization. Mangosteen peel extract gel contains xanthones and flavonoids which are known to be antibacterial and antiinflammatory. This research aims to specify the differences in the effectiveness of anti-inflammatory between mangosteen peel extract and metronidazole gel on fibroblast proliferation. Method: This is a laboratory experimental design using post-test only design consisted of 50% mangosteen peel extract gel group, 75% mangosteen peel extract gel group, 25% metronidazole gel group and metronidazole plus gel group. This research used male Wistar rats induced periodontitis by ligation for 7 days as samples. Results: The results reveal that there was a differences in effectiveness between the 4 groups against the proliferation of fibroblast were analyzed using One Way ANOVA with a significance of 0.000 (p<0.05). Conclusion:It can be concluded that there was differences in the effectiveness of mangosteen peel extract gel and metronidazole gel as anti-inflammatory on proliferation of fibroblast in periodontitis healing process.
Background: Traumatic ulcers are lesions of the oral mucosa caused by mechanical, chemical, and temperature trauma. Traumatic ulcer treatment aims to reduce inflammation, accelerate the healing process, and reduce pain. Bay leaf has anti-inflammatory pharmacological activities. This study aims to determine the effect of bay leaf extract on the expression of fibroblast growth factor in traumatic ulcer oral mucosa in Wistar rats. Method: This is an experimental research with a post-test only control group design, consisting of four groups with 20 sample of male Wistar rats. All animals were injured using a hot burnisher attached to the labial mucosa for 1 second. The gel was applied twice daily until the 3rd and 5th day after the ulcer has formed. Rat mucosal tissues were analyzed by immunohistochemical staining for FGF expressions. Statistical analysis using SPSS Mann-Whitney test. Result: The results showed the mean of cells expressing FGF in the bay gel extract group on the 3rd and 5th days were 8.4 ± 0.8, and 13.6 ± 0.5. Mann Whitney test results showed P<0.05 there is a significant differential expression of FGF traumatic ulcer oral mucosa of experimental animals on days 3 and 5 compared control group. Conclusion: Bay leaf extract increased FGF expression on days 3 and 5 PENDAHULUANUlkus rongga mulut adalah peradangan pada bagian mukosa yang disebabkan kerusakan jaringan epitel rongga mulut dan terbukanya ujung saraf. Traumatik berkaitan adanya trauma mekanik, kimia, dan suhu. Gambaran klinis dari ulkus traumatik merupakan lesi sekunder dengan gambaran khas berupa bentuk soliter bulat, berukuran variatif, kedalaman lesi mencapai lamina propia 1,2,3 .Proses penyembuhan ulkus traumatik dibagi menjadi 3 tahap, fase inflamasi, proliferasi, dan remodeling. Fase inflamasi dibagi menjadi 2 yaitu fase inflamasi awal dan fase inflamasi akhir 4 . Sel yang berperan penting adalah makrofag. Makrofag diklasifikasikan menjadi 2 yaitu makrofag proinflamasi yang berperan pada fase inflamasi awal dan makrofag antiinflamasi atau pro-angiogenik yang berperan pada fase inflamasi akhir.
Background: Estimation of age through teeth is one way to identify living and dead individuals. Age estimates can clarify statements of death, legal and civil matters. One way to identify victims is using periapical radiographs. The use of periapical radiographs in age estimation requires certain method, one of which is the TCI (Tooth Coronal Index) Benindra method modified from Drusini's TCI method. Tooth age assessment using Benindra TCI method based on pulp chamber height measurements.Purpose: to clarify the application of TCI Benindra method in estimating biological age in Semarang population. Material and Method: This research was using total sampling method with a number of 23 periapical radiographs with 7 male and 16 female. The estimated age of the Benindra TCI method was done at the age of 9-21 years and using a mandibular premolar. Tooth age assessment was based on measurements of pulp chamber height using the TCI formula, the results of TCI measurements were entered into the prediction age formula to determine the biological age. Result: the average difference between biological age estimated used the Benindra method and chronological age reached 0,46 years in the 9-21 years age group. There were 7 data that underestimated, 6 data over estimation, and 10 data on estimation.Conclusion: The application of the Benindra TCI method shows good results in estimating the biological age of the Semarang population, because the difference between the estimated age and the chronological age produced by this method is quite small.
Background: Age estimation is forensic science to help victims of disasters, accidents, or criminal cases. Age estimation using panoramic radiographs can be an option. The use of panoramic radiographs in age estimation requiring some methods, one of them is Demirjian method. The assement of tooth age by the Demirjian method is based of the tooth maturation process approach as the indicator.This study aim was to determine the description of biological age estimation using the Demirjian method in the city of Semarang. Method:The design of this research was a cross-sectional study with a total sample 152 (71 boys and 81 girls). The estimated age of the Demirjian method used 7 left mandibular teeth except for the third molar. The age assessment was based on 8 stages of crown calcification to the root, after each tooth score has been added and the maturation score is calculated, and subsequent maturation scores are converted into the age of the tooth to determine the age of 3-16 years. Data analysis using the SPSS program and analyzed by descriptive test. Result: The results obtained by the average difference in biological age and chronological age was 1.1 years and there was 87 data that under estimation, 57 data over estimation, and 8 data on estimation. Conclusion:The depiction of biological age in Semarang, the age group between 3-26 years the average Demirjian method is 1.1 years.
Background: Periodontitis is one of the most common periodontal diseases in Indonesia. Inflammation and the bacteria that cause periodontitis can be treated by providing additional therapy in the form of a gel by the dentist. Mangosteen peel extract gel contains xanthones which function as antibacterial and anti-inflammatory that will accelerate the inflammatory phase. This study aims to determine the effectiveness of a gel made from mangosteen peel extract to increase the number of fibroblast cells on the healing process of periodontitis in Wistar rats. Methods: This is an experimental laboratory with post test only design. The treatment group composed of 50% mangosteen peel extract gel, 75% mangosteen peel extract gel, 25% metronidazole gel, and metronidazole plus mefenamic acid gel which were applied to Wistar rats after periodontitis induced. Results:The research data were analyzed by One Way ANOVA and exhibited a significance score of p = 0.000 (p<0.05) which indicated a significant difference. In the inter-group test with Bonferroni post hoc, it was found that there was no significant difference between the 75% mangosteen peel extract gel group and 25% metronidazole gel group with a score of p = 0.709 (p>0.05). Conclusion:The conclusion of this research showed that mangosteen peel extract gel was effective in increasing the number of fibroblast cells in the recupiration process of periodontitis
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