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Recently, it has been found that moxifloxacin, an antibiotic drug, promotes wound healing without induction to bacterial resistance.

Keeping in view the antimicrobial nature of polyvinylimidazole, the antioxidant property of gum acacia, the mucoadhesive and gel-forming nature of Carbopol, the anesthetic action of lidocaine, and the antimicrobial action of gentamicin, in the present work, an attempt was made to prepare lidocaine and gentamicin loaded gum acacia−Carbopol−polyvinylimidazole based hydrogel wound dressings for better wound healing. These hydrogel dressings were characterized by 13 C NMR, FTIR, SEM, cryo-SEM, AFM, XRD, DSC, swelling, and network parameter studies. Some properties of wound dressings were also determined which include the following: hemolysis, hemostatic potential, oxygen permeability, water vapor transmission rate, antioxidant activity, mucoadhesion, protein adsorption, degradation studies, antimicrobial properties (against Pseudomonas aeruginosa bacteria), microbial penetration, mechanical properties (tensile strength, burst strength, resilience, relaxation, folding endurance and gel strength) drug release, and histological studies. The synergic effects of the mucoadhesive, antimicrobial, and antioxidant nature of hydrogel dressings make them suitable candidate as wound dressing material.

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In the present work an attempt has been made to design the antibiotic drug loaded carbopolpoly(NVP) based hydrogel wound dressings for better wound care. The polymer films were characterized by SEM-EDX, AFM, FTIR, 13 CNMR, TGA/DTA/DTG, DSC, and swelling studies. Besides drug release, various biomedical properties (viz. blood compatibility, mucoadhesion, oxygen permeability, water vapour transmission rate, microbial penetration, tensile strength, bursting strength, resilience, stress relaxation, and folding endurance) have also been studied. The polymer films have been observed to be biocompatible, permeable to oxygen and water vapour and have absorbed simulated wound fluid 11.37±0.31g/g of polymer film. The drug release profile followed the Case-II diffusion mechanism and release profile best fitted in Hixson-Crowell's kinetic models. Mechanical properties results showed that the polymer film had 0.65±0.12 Nmm −2 tensile strength, 119.38±14.26% elongationand 25.49±0.72% resilience.