Acacia gum polysaccharide based hydrogel wound dressings: Synthesis, characterization, drug delivery and biomedical properties

Singh, Baljit; Sharma, Sushma; Dhiman, Abhishek

doi:10.1016/j.carbpol.2017.02.039

Cited by 95 publications

(30 citation statements)

References 42 publications

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“…[40] Peak at 1656 and 1655 cm −1 appears due to presence of CO stretching for Ga (figure c-i, ii, iii, and iv). [41] Presence of aromatic C-N stretching of C 3 N 4 is confirmed by peaks 795 and 773 cm −1 (figure c-iii). [42,43] Peak at 1218 cm −1 confirmed stretching of aromatic C-N group in NMBA.…”

Section: Fabricating Of Nanocomposite Hydrogel and Swelling Studiesmentioning

confidence: 87%

Gum Acacia‐cl‐poly(acrylamide)@carbon nitride Nanocomposite Hydrogel for Adsorption of Ciprofloxacin and its Sustained Release in Artificial Ocular Solution

Sharma

Thakur

Kumar

et al. 2020

Macro Materials & Eng

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In the present work, a nanocomposite hydrogel is designed consisting of gum acacia, poly(acrylamide) and carbon nitride by facile microwave approach. This nanocomposite hydrogel is sensitive to environmental stimuli which is essential for its application in environmental remediation and as a drug delivery system. The effects of carbon nitride percentage and microwave Watt variation on swelling capacity of gum acacia‐cl‐poly(acrylamide)@carbon nitride (Ga‐cl‐PAM@C3N4) nanocomposite hydrogel are analyzed. The structural characterizations are considered by numerous techniques such as FTIR (Fourier transform infra‐red spectroscopy), X‐ray diffraction, transmission electron microscopy, scanning electron microscopy, and elemental mapping. Batch experiment is performed for remediation of ciprofloxacin (CIP) drug from water. Various parameters such as effect of ciprofloxacin doses, Ga‐cl‐PAM@C3N4 nanocomposite hydrogel dosage, pH, time and temperature for adsorption of CIP on gum acacia‐cl‐poly(acrylamide)@carbon nitride nanocomposite hydrogel is examined. Maximum adsorption capacity of Ga‐cl‐PAM@C3N4 nanocomposite hydrogel observed is 169.49 mg g−1 at pH 6.4. The drug loading and drug release capacity of Ga‐cl‐PAM@C3N4 nanocomposite hydrogel is investigated for ciprofloxacin. Drug release is monitored in artificial ocular solution (pH 8), saline (pH 5.5), acetate buffer (pH 2.2), and distilled water. Maximum drug release is observed in artificial ocular solution.

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Section: Fabricating Of Nanocomposite Hydrogel and Swelling Studiesmentioning

confidence: 87%

Gum Acacia‐cl‐poly(acrylamide)@carbon nitride Nanocomposite Hydrogel for Adsorption of Ciprofloxacin and its Sustained Release in Artificial Ocular Solution

Sharma

Thakur

Kumar

et al. 2020

Macro Materials & Eng

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“…Acacia gum (AcG)/polyvinylpyrollidone/carbopol hydrogel films for wound dressing exhibited antioxidant, non-hemolytic, and mucoadhesive in nature and absorbed wound fluid. In addition, hydrogel films that showed the release of the moxifloxacin drug from the hydrogel network followed non-Fickian diffusion mechanism and were best-fitted to the Higuchi model [187]. Further, ZnO NPs show antimicrobial behavior and improve the wound healing process.…”

Section: Wound Dressingmentioning

confidence: 91%

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

et al. 2020

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The engineering of tissues under a three-dimensional (3D) microenvironment is a great challenge and needs a suitable supporting biomaterial-based scaffold that may facilitate cell attachment, spreading, proliferation, migration, and differentiation for proper tissue regeneration or organ reconstruction. Polysaccharides as natural polymers promise great potential in the preparation of a three-dimensional artificial extracellular matrix (ECM) (i.e., hydrogel) via various processing methods and conditions. Natural polymers, especially gums, based upon hydrogel systems, provide similarities largely with the native ECM and excellent biological response. Here, we review the origin and physico-chemical characteristics of potentially used natural gums. In addition, various forms of scaffolds (e.g., nanofibrous, 3D printed-constructs) based on gums and their efficacy in 3D cell culture and various tissue regenerations such as bone, osteoarthritis and cartilage, skin/wound, retinal, neural, and other tissues are discussed. Finally, the advantages and limitations of natural gums are precisely described for future perspectives in tissue engineering and regenerative medicine in the concluding remarks.

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“…Hydrogel‐based wound dressings are one of the most effective methods for wound treatment, which meets the important dressing requirements, including: a) allowing gases to be exchanged at the interface of wound and outside, b) keeping the wound moist while absorbing a large amount of exudate and maintaining constant temperature of the wound through the interface, c) pain reduction through cooling the surface and active intervention during the wound healing process, d) preventing the bacteria from infracting the wound surface. Due to the excellent properties of polysaccharides' mentioned before, they have been researched for use as a wound dressing material …”

Section: Biomedical Applications Of Polysaccharides and Polysaccharidmentioning

confidence: 99%

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Zhu

Mao

Cheng

et al. 2019

Adv Materials Inter

260

142

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Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.

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Acacia gum polysaccharide based hydrogel wound dressings: Synthesis, characterization, drug delivery and biomedical properties

Cited by 95 publications

References 42 publications

Gum Acacia‐cl‐poly(acrylamide)@carbon nitride Nanocomposite Hydrogel for Adsorption of Ciprofloxacin and its Sustained Release in Artificial Ocular Solution

Gum Acacia‐cl‐poly(acrylamide)@carbon nitride Nanocomposite Hydrogel for Adsorption of Ciprofloxacin and its Sustained Release in Artificial Ocular Solution

Recent Advances in Natural Gum-Based Biomaterials for Tissue Engineering and Regenerative Medicine: A Review

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

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