Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Singh, Baljit; Dhiman, Abhishek

doi:10.25082/jpbr.2019.01.001

Cited by 15 publications

(11 citation statements)

References 64 publications

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“…Similarly, two endothermic peaks are indicated at 280 °C and 310 °C, respectively, followed by a phase glass transition. This indicates that developed hydrogels lead to thermal degradation in the range of 350–400 °C, although the thermal stability of the developed hydrogels exhibits better stability than the individual components [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

Using Carbomer-Based Hydrogels for Control the Release Rate of Diclofenac Sodium: Preparation and In Vitro Evaluation

Suhail

Minhas

2020

Pharmaceuticals

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The aim of the current research work was to prepare Car934-g-poly(acrylic acid) hydrogels by the free-radical polymerization technique. Various concentrations of carbopol, acrylic acid and ethylene glycol dimethacrylate were employed for the fabrication of Car934-g-poly(acrylic acid) hydrogels. Fourier-transform infrared spectroscopy (FTIR), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Scanning electron microscope (SEM) and Powder X-ray diffractometry (PXRD) studies were performed to know the structural arrangement, thermal stability, physical appearance and amorphous network of developed hydrogels. FTIR analysis revealed that carbopol reacted with acrylic acid during the process of polymerization and confirmed the grafting of acrylic acid over the backbone of carbopol. TGA and DSC studies showed that developed hydrogels were thermally stable. Surface morphology was analyzed by SEM, which confirmed a porous network of hydrogels. PXRD analysis indicated that crystallinity of the drug was reduced by the amorphous network of hydrogels. Furthermore, swelling studies for all developed hydrogels were performed at both media, i.e., pH 1.2 and 7.4, and higher swelling was exhibited at pH 7.4. Sol–gel analysis was performed to evaluate the soluble unreacted part of the fabricated hydrogels. Similarly, an in-vitro study was conducted for all hydrogel formulations at both acidic (pH 1.2) and basic (pH 7.4) mediums, and a greater drug release was observed at pH 7.4. Different kinetics such as zero-order, first-order, the Higuchi model and the Korsmeyer–Peppas model were applied to know the mechanism of release order of drugs from the hydrogels.

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Section: Resultsmentioning

confidence: 99%

Using Carbomer-Based Hydrogels for Control the Release Rate of Diclofenac Sodium: Preparation and In Vitro Evaluation

Suhail

Minhas

2020

Pharmaceuticals

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“…Figure b,c shows the DSC thermograms of PAA, PAA/HA, and PAA/functionalized-HA hydrogels (HG) evaluated at pH = 7.4 and 4.1. All thermograms exhibit three characteristic regions ascribed to the following transitions: − (A) water, melting transition, T m ; (B) water, evaporation transition, T e ; and (C) polymer, glass transition ( T g ). After deconvolution, the identified regions turned out to be the sum of several peaks representing different phase switches; thermodynamic parameters are summarized in Table S2.…”

Section: Resultsmentioning

confidence: 99%

Hydroxyapatite Nanoparticle Mesogens: Morphogenesis of pH-Sensitive Macromolecular Liquid Crystals

Benedini

Moglie

Ruso

et al. 2021

Crystal Growth & Design

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Numerous living structural materials display self-assembly of building blocks. Biological molecular networks exhibit lyotropic liquid crystalline properties that can support non-equilibrium pathways influenced by dynamic processes at the microscale. With the aim of taking a further step toward the conquest of a biomimetic material to apply in calcified tissue regeneration, in this work, we have evaluated the chemical grafting of phosphorous amide (C–N–P) and α-amino phosphonate (N–C–P) molecular fragments on previously created biomimetic hydroxyapatite (HA) nanoparticles (nano-HA). Molecular combinations were selected due to their recognized capability of influencing bone physiology and pathology. We have assessed the effect of the type and degree of nano-HA substitution over the spontaneous self-association of acidic macromolecules that respond to pH stimulation. The produced materials were inspected by Fourier transform infrared and solid-state nuclear magnetic resonance spectroscopy, small-angle X-ray scattering, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and polarized light and high-resolution electron transmission microscopy. A complete analysis of the experimental data proved that under specific synthetic conditions, it is possible to obtain substituted-HA nanoparticles that are able to act as mesogenic agents. These systems that dynamically respond to pH can be tailored in vitro to induce, at concentration values analogous to biogenic ones, lyotropic liquid crystal organization on acid macromolecules.

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“…Conclusively, the discussion demonstrates that the fabricated network of microgel was thermally stable due to the cross-linking of its basic unreacted ingredients. B. Singh et al (2019) developed carbopol-based hydrogels and reported high thermal stability for fabricated hydrogels [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…Aliquot of 5 mL was taken after a regular interval of time and a medium of the same quantity was added back to maintain the sink condition constant throughout the dissolution experiment. The collected aliquots were analyzed on a UV-vis spectrophotometer (U-5100, 3J2-0014, Tokyo, Japan) at λ max 272 nm in triplicate [ 43 ]. In order to deduce the release mechanism of TP from ASPA-pAMPS microgels, zero order, first order, Korsmeyer–Peppas, and Higuchi kinetic models were applied for all formulations of the developed microgels [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Synthesis and In Vitro Evaluation of Aspartic Acid Based Microgels for Sustained Drug Delivery

Suhail

Xie

Liu

et al. 2021

Gels

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The main focus of the current study was to sustain the releasing behavior of theophylline by fabricated polymeric microgels. The free radical polymerization technique was used for the development of aspartic acid-co-poly(2-acrylamido-2-methylpropanesulfonic acid) microgels while using various combinations of aspartic acid, 2-acrylamido-2-methylpropanesulfonic acid, and N′,N′-methylene bisacrylamide as a polymer, monomer, and cross-linker, respectively. Ammonium peroxodisulfate and sodium hydrogen sulfite were used as initiators. Characterizations such as DSC, TGA, SEM, FTIR, and PXRD were performed for the fabricated microgels to assess their thermal stability with unreacted polymer and monomer, their surface morphology, the formation of a new polymeric system of microgels by evaluating the cross-linking of functional groups of the microgels’ contents, and to analyze the reduction in crystallinity of the theophylline by fabricated microgels. Various studies such as dynamic swelling, drug loading, sol–gel analysis, in vitro drug release studies, and kinetic modeling were carried out for the developed microgels. Both dynamic swelling and percent drug release were found higher at pH 7.4 as compared to pH 1.2 due to the deprotonation of functional groups of aspartic acid and AMPS. Similarly, sol–gel analysis was performed and an increase in gel fraction was observed with the increasing concentration of microgel contents, while sol fraction was decreased. Conclusively, the prepared carrier system has the potential to sustain the release of the theophylline for an extended period of time.

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Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management

Cited by 15 publications

References 64 publications

Using Carbomer-Based Hydrogels for Control the Release Rate of Diclofenac Sodium: Preparation and In Vitro Evaluation

Using Carbomer-Based Hydrogels for Control the Release Rate of Diclofenac Sodium: Preparation and In Vitro Evaluation

Hydroxyapatite Nanoparticle Mesogens: Morphogenesis of pH-Sensitive Macromolecular Liquid Crystals

Synthesis and In Vitro Evaluation of Aspartic Acid Based Microgels for Sustained Drug Delivery

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