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Here we show that 3D silk scaffolds loaded with nicotinic acid have great potential for tissue engineering due to their excellent cytocompatibility and ability to decrease the expression of proinflammatory markers in a concentration dependent manner.

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This study has focused on mesoporous silica nanoparticles as a drug delivery system of insulin, which was synthesized via a hydrothermal process. The morphology and composition of the silica nanoparticles were characterized by different analytical techniques such as Scanning Electron Microscope (SEM), X-Ray Diffraction Analysis (XRD), Fourier Transform Infrared spectroscopy (FTIR) and BrunauerEmmettTeller (BET). The percentage of drug loading and the in vitro drug release properties of the mesoporous silica nanoparticles in gastrointestinal tract were investigated in simulated gastrointestinal conditions by ultraviolet-visible spectroscopy. The results showed the amorphous structure of SBA-15 in mesoporous silica particles has a narrow pore size distribution. Also, particles shape was nearly wheat-like with almost homogeneous size distribution. Furthermore, it was revealed that the mesoporous silica nanoparticles have a high insulin loading and release capacity. These prominent behaviors make mesoporous silica nanoparticles promising material as a drug carrier for insulin delivery.

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Correction for ‘Silk based scaffolds with immunomodulatory capacity: anti-inflammatory effects of nicotinic acid’ by Abdollah Zakeri Siavashani et al., Biomater. Sci., 2019, DOI: 10.1039/c9bm00814d.