Effect of amino-functionalization on insulin delivery and cell viability for two types of silica mesoporous structures

Siavashani, Abdollah Zakeri; Nazarpak, Masoumeh Haghbin; Fayyazbakhsh, Fateme; Toliyat, Tayebeh; McInnes, Steven J. P.; Solati‐Hashjin, Mehran

doi:10.1007/s10853-016-0301-1

Cited by 23 publications

(5 citation statements)

References 58 publications

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“…As shown in Fig. 3c, the SAXRD pattern of MSNs showed four peaks corresponding to diffraction of (100), (110), (200), and (210) planes, which are the characteristic peaks of MCM-41 type MSNs, indicating that the synthesized MSNs have hexagonal type of mesoporous structure [40, 49] that supported the TEM results discussed previously. Three measurements were taken of the samples.…”

Section: Resultssupporting

confidence: 83%

Mesoporous silicate nanoparticles/3D nanofibrous scaffold-mediated dual-drug delivery for bone tissue engineering

Yao

Liu

Selvaratnam

et al. 2018

Journal of Controlled Release

111

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Controlled delivery systems play a critical role in the success of bone morphogenetic proteins (i.e., BMP2 and BMP7) for challenged bone repair. Instead of single-drug release that is currently and commonly prevalent, dual-drug delivery strategies are highly desired to achieve effective bone regeneration because natural bone repair process is driven by multiple factors. Particularly, angiogenesis is essential for osteogenesis and requires more than just one factor (e.g., Vascular Endothelial Growth Factor, VEGF). Therefore, we developed a novel mesoporous silicate nanoparticles (MSNs) incorporated-3D nanofibrous gelatin (GF) scaffold for dual-delivery of BMP2 and deferoxamine (DFO). DFO is a hypoxia-mimetic drug that can activate hypoxia-inducible factor-1 alpha (HIF-1α), and trigger subsequent angiogenesis. Sustained BMP2 release system was achieved through encapsulation into large-pored MSNs, while the relative short-term release of DFO was engineered through covalent conjugation with chitosan to reduce its cytotoxicity and elongate its half-life. Both MSNs and DFO were incorporated onto a porous 3D GF scaffold to serve as a biomimetic osteogenic microenvironment. Our data indicated that DFO and BMP2 were released from a scaffold at different release rates (10 vs 28 days) yet maintained their angiogenic and osteogenic ability, respectively. Importantly, our data indicated that the released DFO significantly improved BMP2-induced osteogenic differentiation where the dose/duration was important for its effects in both mouse and human stem cell models. Thus, we developed a novel and tunable MSNs/GF 3D scaffold-mediated dual-drug delivery system and studied the potential application of the both FDA-approved DFO and BMP2 for bone tissue engineering.

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Section: Resultssupporting

confidence: 83%

Mesoporous silicate nanoparticles/3D nanofibrous scaffold-mediated dual-drug delivery for bone tissue engineering

Yao

Liu

Selvaratnam

et al. 2018

Journal of Controlled Release

111

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“…The dod cage has an accessible window size of ∼1.3 nm shared with the mcp-d cage that has additional hexagonal windows of ∼1.7 nm as shown in Figure 2. 39 Considering the wide investigations of mesoporous silica materials for encapsulation of active molecules for biocatalysis 40 and prolonged drug delivery for decades, 41,42 a mesoporous silica material, MCM-41, was also investigated for comparison. 43 ■ EXPERIMENTAL SECTION General Information.…”

Section: ■ Introductionmentioning

confidence: 99%

Investigation of the Mesoporous Metal–Organic Framework as a New Platform To Study the Transport Phenomena of Biomolecules

Chen

Hong

et al. 2017

ACS Appl. Mater. Interfaces

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Mesoporous materials, Tb-mesoMOF and MCM-41, were used to study the transport phenomena of biomolecules entering the interior pores from solution. Vitamins B and B were successfully encapsulated into these mesoporous materials, whereas Tb-mesoMOF (0.33 g of B/g, 0.01 g of B/g) adsorbed a higher amount of vitamin per mass than MCM-41 (0.21 g of B/g, 0.002 g of B/g). The diffusion mechanism of the biomolecules entering Tb-mesoMOF was evaluated using a mathematical model. The Raman spectroscopy studies showed vitamin B has been encapsulated within Tb-mesoMOF's pores, and evaluation of the peak shifts indicated strong interactions linking vitamin B's pyrroline moiety with Tb-mesoMOF's triazine and benzoate rings. Because of these stronger interactions between the vitamins and Tb-mesoMOF, longer egress times were observed than with MCM-41.

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“…25 The peak at 1464 cm À1 can be attributed to the N-H stretching absorption of the aminopropyl groups. 26 The new peaks conrmed the presence of APTES on A-HT, which indicated the successful modication of nanoparticles. For the TMC-reacted A-HT, the new peaks at 1800 cm À1 and 1441 cm À1 could be assigned to the C]O stretching absorption and O-H deformation of carboxylic acid group, which came from the hydrolysis of the unreacted acyl chloride unit.…”

Section: Resultsmentioning

confidence: 95%

Development of high-performance mixed matrix reverse osmosis membranes by incorporating aminosilane-modified hydrotalcite

Cao¹,

Wang²,

Chen³

et al. 2020

RSC Adv.

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Effect of amino-functionalization on insulin delivery and cell viability for two types of silica mesoporous structures

Cited by 23 publications

References 58 publications

Mesoporous silicate nanoparticles/3D nanofibrous scaffold-mediated dual-drug delivery for bone tissue engineering

Mesoporous silicate nanoparticles/3D nanofibrous scaffold-mediated dual-drug delivery for bone tissue engineering

Investigation of the Mesoporous Metal–Organic Framework as a New Platform To Study the Transport Phenomena of Biomolecules

Development of high-performance mixed matrix reverse osmosis membranes by incorporating aminosilane-modified hydrotalcite

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