The study was carried out to determine the antimicrobial activities of Carica papaya and its major antimicrobial constituents (phytochemicals). The aqueous and ethanol extracts from the leaves and stem back of these plants were tested using well Diffusion method for their antimicrobial activity against some members of Enterobacteriales family isolated from diarrheic stool sample (Escherichia coli, Shigella spp, Salmonella typhi and Pseudomonas aeruginosa). Statistical analysis of the result shows that both the extracts demonstrated higher activities against bacteria tested, with the average zone of inhibition of 15.44mm, 14.78mm, 12.92mm and 11.31mm for Shigella, Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa respectively. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the extracts ranges between 12.5-100 mg/ml. Preliminary phytochemical analyses showed that the extracts contain alkaloids, tannins, terpenoids, anthraquinones, reducing sugar, amino acid, flavonoids, saponins, glycosides and phenols. Demonstration of antibacterial activity against the test isolates is an indication that there is possibility of sourcing alternative antibiotic substances in these plants for the production of newer antibacterial agents.
Malaria and typhoid fever are of tremendous public health concern in sub inclusive). Because of the high prevalence of malaria and typhoid fever in Nigeria, co common. This study was aimed at determining the prevalence co-infection among febrile patients in Kumbotso Local Government Area Kano, Nigeria. A Total of 125 subjects of both age and sex suggestive of Malaria and/or typhoid fever were used as participants. Five milliliter (5 ml) of blood samples were collected from each of the participant for widal tests and blood film from a period of April, 2015 to October, 2015. The results revealed a malaria prevalence of 55% (69/125). The sero while 22% (28/125) had malaria and typhoid fever co negative for both malaria and typhoid fever. However, the result showed that malaria is more likely to cause fever than typhoid infection. Statistical analysis of th significant different on the incident of malaria and that of typhoid fever among febrile patients at p > 0.05. It is recommended that intervention programs aimed at reducing malaria and typhoid infections should be increased in such areas, especially in the wet seasons.
Objectives of the Study: An Epidemiological Research, a cross-sectional study, was conducted to determine the magnitude of human contamination of irrigation canal perimeter as it relates to the prevalence and intensity of schistosome cercarial infection in snail vectors.
Place and Duration of Study: The study was conducted along water canal located within an irrigation area, Kano River Project Phase I, Kadawa, between January and June, 2012.
Methodology: The study area was categorized into Zone of Heavy Contamination (ZHC), Zone of Light Contamination (ZLC) and Zone of Free Contamination (ZFC) based on the density of faecal lumps observed along the canal perimeter using 1 m2 quadrat sampling technique. Snail vectors of schistosomiasis were collected from these zones, identified and subjected to cercarial shedding. Brevifurcate apharyngeate cercariae were identified as schistosome cercariae.
Results: Of the 827 snails collected 28.54% shed schistosome cercariae. The breakdown of infection prevalence was 31.37%, 27.69% and 26.26% for ZHC, ZLC and ZFC respectively. Three snail species recovered in the study area, Bulinus globosus, B. rohlfsi and Biomphalaria pfeifferi had infection intensity of 8.6, 5.67 and 3.94 respectively, with total mean intensity of 4.67. A Chi-squared analysis did not show any significant difference in infection prevalence in the three zones (χ2cal. 0.025, χ22, 0.05 = 5.99). However, infection intensity was significantly different in the three zones and among the three snail species using analysis of variance (P<0.05).
Conclusion: Human environmental contamination with faeces and urine around irrigation canals remains the source of infection to snail hosts and then to humans. It is presumed that contact control through avoidance of defaecation in the open and building of pit latrines near water contact points along irrigation canals will be effective means of drawing a barrier to infection with schistosomes in the study area.
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