The study was aimed to investigate the phytochemical constituents and antibacterial activity of Senna siamea leaves extracts against some pathogen bacteria. Aqueous and ethanol extracts from Senna siamea leaves were prepared, screened for phytochemical analysis and tested for its antibacterial activity against 6 pathogenic bacteria (Klebsiella pneumoneae, Salmonella typhi, Shigella spp, Escherichia coli, and Pseudomonas aeruginosa) recovered from stool sample of patients attending Murtala Muhammad Specialist Hospital Kano. Phytochemical screening of the extracts showed that Senna siamea extract contain Alkaloid, Anthraquinone, saponin, tannin, phenol, steroid, flavonoid, terpenoid and glycosides. Statistical analysis of the result showed that highest antibacterial activity was recorded in ethanol extract with average zone of inhibition of 14.12±1.51 mm among the isolates while aqueous extracts recorded an average zone of inhibition of 12.00±1.06 mm. Based on the susceptibility of the organisms to the extracts, E. coli was found to be the highest susceptible organisms with average zone of inhibition of 14.29±1.12 mm, followed S. aureus(13.61±1.23mm), Salmonella typhi(13.56±1.89mm), Shigella (13.22±1.41mm), Pseudomonas(12.36±1.38mm) while least average zone of inhibition is shown by Klebsiella(11.33±0.80mm). The MIC and MBC of the extracts ranges from 3.125 to 50mg/ ml There is no significant different on the susceptibility of the organisms against the extracts at p<0.05. The results of the present study have supported the therapeutic potential of Senna siamea and its use as medicinal plant.