Phytochemical Composition and Antimalarial Activity of Methanol Leaf Extract of Crateva adansonii in Plasmodium berghei Infected Mice

Tsado, Amos Ndarubu; Bashir, Lawal; Mohammed, Suleiman Adamu; Famous, I O; Yahaya, A.; Aibu, M Shu; Caleb, T.

doi:10.9734/bbj/2015/16038

Cited by 18 publications

(10 citation statements)

References 14 publications

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“…The presence of important phytochemical in this plant is an indication that this plant if properly screened could yield a drug of pharmaceutical significance. However, the absence of phlobatannins agree with early studies which also found that not all phytochemicals are present in all plant and those that present differs according to the solvent use in the extraction process [31][32]. Alloxan induced diabetic untreated rats shows progressive increase in blood glucose level throughout the study period.…”

Section: Resultssupporting

confidence: 88%

Phytochemicals, hypoglycemic and hypolipidemic effects of methanol leaf extract of Hibiscus sabdariffa in alloxan induced diabetic rats

Tsado¹,

Onukogu²,

Alfa³

et al. 2019

GSC Biol. and Pharm. Sci.

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This study investigates the phytochemicals, antidiabetic and hypolipidemic activities of Hibiscus sabdariffa methanol leaves extract in alloxan induced diabetic wistar rat by administering graded oral doses (100, 200 and 400 mg/kg body weight) for 21 days. Results revealed that the methanol leaf extract of Hibiscus sabdariffa contains 51.90±3.89 mg/100g of tannins, 102.56±6.89 mg/100g of saponins, 54.78±3.89 mg/100g of alkaloids, 67.45±3.87 mg/100g of flavonoids and 121.54±5.67 mg/100g of phenols. The extract showed dosed dependent significant (p<0.05) antidiabetic activity with significant improvement in body weight. The extract also resulted in significant (p<0.05) reduction serum cholesterol, triglycerides. LDL-cholesterol level and increase HDL-cholesterol when compared with untreated control. In conclusion, this study demonstrates, for the first time, that Hibiscus sabdariffa is effective in inhibiting hyperglycemia and dyslipidemia in diabetes condition.

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Section: Resultssupporting

confidence: 88%

Phytochemicals, hypoglycemic and hypolipidemic effects of methanol leaf extract of Hibiscus sabdariffa in alloxan induced diabetic rats

Tsado¹,

Onukogu²,

Alfa³

et al. 2019

GSC Biol. and Pharm. Sci.

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“…More significant suppressive effects were noted at 400 mg/kg and 600 mg/kg dose level. e chemosuppression activity of the crude extract was in a dose-dependent manner which could be attributed to the concentration of schizonticidal compounds in the extract [1,25]. is antimalarial activity observed in M. dianthera plant extract is in agreement with the other studies on different plant species of Lamiaceae family.…”

Section: Discussionsupporting

confidence: 88%

Antimalarial Activity of Meriandra dianthera Leaf Extracts in Plasmodium berghei‐Infected Mice

Hagazy

Sibhat

Karim

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To evaluate the antimalarial effect of aqueous methanolic extract and solvent fractions of Meriandra dianthera leaves against Plasmodium berghei in mice model. Method. M. dianthera leaves were extracted with 80% methanol and dried. The dried crude extract was then defatted and further fractionated with chloroform, ethyl acetate, and butanol. Acute oral toxicity test was performed as per the Organization for Economic Cooperation and Development guideline 425. Peter’s 4-day suppressive test was used to determine the in vivo antimalarial activity of the extract and fractions. Result. The crude leaf extract of Meriandra dianthera showed parasite inhibition of 42.28% and 45.52% at doses of 400 and 600 mg/kg, respectively, as compared to the negative control. Moreover, the mice which received chloroform and aqueous fractions at the dose of 400 mg/kg/day showed significant (P<0.001) chemosuppression compared to the negative control. Both the extract and fractions were able to prevent P. berghei induced body weight loss and body temperature reduction and also increased the survival time of the mice as compared to the negative control. The aqueous methanolic leaf extract of M. dianthera showed no gross signs of toxicity or mortality in mice until a single oral dose of 2000 mg/kg. Conclusion. The extracts of M. dianthera leaves showed promising antimalarial activity, with no sign of toxicity and therefore may support its traditional use for the treatment of malaria.

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“…Therefore, the screening of medicinal plants known for their anti-malarial properties is gaining popularity. Newbouldia laevis (N. laevis) and Crateva adansonii (C. adansonii) are few of such plants that are suspected in Nigeria for their effects against malaria related fever [13,14]. This study was planned to investigate the N. laevis and C. adansonii leaf extracts for their anti-plasmodial activities.…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity Studies and Anti-plasmodial Potentials of Newbouldia laevis and Crateva adansonii in Plasmodium Berghei-infected Mice

Tsado

Jigam

Akanya

et al. 2020

IJT

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Background: Newbouldia laevis and Crateva adansonii are popular plants used traditionally in the management of patients with malaria infection in Nigeria. In this study, the acute toxicity and anti-plasmodial effects of the leaf extracts of Newbouldia laevis and Crateva adansonii were investigated in mice. Methods: The Anti-plasmodial activities of both extracts were investigated individually and combined in mice infected with the chloroquine sensitive ANKA-65 Plasmodium berghei strain. Five groups of four mice each were used in our experiments. The LD50 was determined, using the line equation of the mortality against dose levels plot. Results: The extracts of N. laevis and C. adansonii had a safety level of 200 mg/kg (LD50= 471.43 mg/kg) and 600 mg/kg (LD50=3,500 mg/kg), respectively. Each experimental group was infected with P. berghei strain. The percent inhibition of parasitemia induced by the extracts of N. laevis and C. adansonii were 30.14±2.88% and 61.35±1.41%, respectively, compared to the 78.89% achieved for the standard drug (chloroquine). Mice treated with the combined extracts had a parasite inhibition of 24.23±0.86%. Upon the analysis of the extracts, there were tannins, steroids, flavonoids, saponins and alkaloids in both. The quantitative analyses revealed that tannins were the most abundant (261.85±4.76 mg/100 g & 92.71±6.58 mg/100 g) while saponins were the least abundant (15.09±1.13 mg/100 g & 14.08±1.28 mg/100 g) phytochemicals in both extracts. Conclusion: The findings support the notion that the traditional use of either plant in the management of malaria in Nigeria appears to be logical.

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Phytochemical Composition and Antimalarial Activity of Methanol Leaf Extract of Crateva adansonii in Plasmodium berghei Infected Mice

Cited by 18 publications

References 14 publications

Phytochemicals, hypoglycemic and hypolipidemic effects of methanol leaf extract of Hibiscus sabdariffa in alloxan induced diabetic rats

Phytochemicals, hypoglycemic and hypolipidemic effects of methanol leaf extract of Hibiscus sabdariffa in alloxan induced diabetic rats

Antimalarial Activity of Meriandra dianthera Leaf Extracts in Plasmodium berghei‐Infected Mice

Acute Toxicity Studies and Anti-plasmodial Potentials of Newbouldia laevis and Crateva adansonii in Plasmodium Berghei-infected Mice

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