We report and discuss a case consisting of 2 lesions that developed at different times in the same parotid gland. Although the first lesion showed morphologic features similar to those of the benign lymphoepithelial lesion, a monotypic IgM/K pattern was also revealed by the immunoperoxidase method in its lymphoid infiltrates. Thus, on cytologic grounds, the first lesion was classified as lymphoplasmacytic immunocytoma (according to Kiel criteria). In the second lesion, which recurred 3 years later, the prominent feature was a marked predominance of plasma cells with the same monoclonal IgM/K as the preceding lymphoma. These findings suggests that a B-lymphomatous cell monoclone may undergo morphologic maturation along the lineage of its competence. Secondly, they indicate that every case of benign lymphoepithelial lesion of the salivary glands should undergo thorough immunologic evaluation to exclude the possibility of signs of precocious lymphomatous transformation.
Angiogenic capacity was tested in 14 non-Hodgkin's lymphomas, 7 Hodgkin's lymphomas and 15 cervical lymph nodes nonneoplastic but draining a territory with a laryngeal carcinoma. The objective was to find out whether different groups of lymphomas showed differences in their angiogenic capacity and to compare the ability to induce neovascularization of neoplastic lymphocytes. Frequency and intensity of the angiogenic response were similar for classes of lymphomas different for morphologic and immunologic characteristics. The presence of a carcinoma was sufficient to induce in tributary, nonmetastatic lymph nodes an angiogenic activity comparable to that known to characterize antigenically stimulated lymphocytes.
The present paper describes lymphomagenesis in Swiss mice given nitrosomethylurea (NMU) at birth, and thymectomized at 12 days of age. In mice, at this age, migration of T lymphocytes to other parts of the body has already taken place. On the other hand, the precocious thymectomy prevents any possible interference between thymus and the extrathymic lymphoid system in lymphomagenesis since the major target organ for NMU lymphoma induction is absent. No lymphatic tumours developed in NMU-treated thymectomized mice, although they survived for a long time after thymectomy and about twice as long as the time required for thymus lymphoma production. It can be concluded that NMU in the present experimental system induces lymphomas exclusively in the thymus, while the thymus-dependent and independent areas of the peripheral lymphatic tissues are not affected.
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