The results of this study suggest that S-phase fraction of cirrhotic liver parenchyma may be employed as a new parameter in the prognostic evaluation of HCC patients.
Flow cytometric analysis of DNA content was done on 133 primary squamous cell carcinomas of the larynx. Overall, 76 tumors (57.1%) were not diploid (aneuploid or tetraploid). The DNA index (DI) was calculated and grouped into three levels. Fifty-seven cases had a DI in a range of 1.85 to 2.15 (44 diploid and 13 tetraploid). The cases were grouped in relation to ploidy, proliferative index, and the tumor-node-metastasis (TNM) system. Every group was analyzed with respect to survival rate. Ploidy was related to histocytologic grade. In well-differentiated tumors (G1) survival rates at 48 months were 41.7% in diploid cases and 27.7% in nondiploid ones (relative risk [RR], 2.01; 95% confidence interval [CI], 0.89, 4.52). In NO cases that underwent surgery, survival rates at 48 months were, respectively, 81.8% and 49.2% (RR, 5.07; 95% CI, 0.76, 33.93). These results suggest that ploidy may be a new independent parameter of prognosis in squamous cell carcinoma of the larynx. This is useful in clinical practice because it allows the clinician to recognize those cases with poorer prognosis among the early tumors at a stage where other prognostic parameters are not yet available.
A male infant was delivered by elective Caesarean section weighing 4164g (between 99th and 99.6th centile) at 37 weeks gestation. Antenatal corticosteroids were administered prior to delivery. APGAR scores were 8 at one minute and 9 at five minutes. The baby was assessed by the paediatric surgical team and underwent emergency laparotomy, ileostomy and mucus fistula formation within 12 hours of delivery. Intraoperatively there was generalised peritoneal contamination and ascites with luminal content in the peritoneal cavity. A perforation of the small bowel, approximately 10cm from the terminal ileum was noted. Antenatal bowel perforation is an uncommon condition, with an incidence of 1/35,000. Ultrasound and MRI findings prior to delivery were in keeping with clinical findings at laparotomy of ascites and meconium peritonitis. VP09.19 Omphalocele: a bland pathology? Review of a series of cases in the Obstetrics and
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