Malignant lymphomas and renal changes in Swiss mice given nitrosomethylurea

Terrachini, B.; Stramignoni, A

doi:10.1016/0014-2964(67)90028-x

Cited by 16 publications

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“…These tumours were malignant and multi-organ spread was often present. Many appeared to have arisen in the thymus and involved the lungs, heart, spleen, lymph nodes, liver and kidney, similarly to the lymphomata reported by Terracini and Stramignoni (1968) in MNU-treated Swiss mice. Less commonly the malignant lymphomata were composed of large cells.…”

Section: Discussionsupporting

confidence: 65%

“…Treatment of mice with MNU has been reported to give rise to leukaemia (Graffi and Hoffmann, 1966), malignant lymphoma (Terracini and Stramignoni, 1968), lymphomata, lung adenomata and hepatomata (Terracini and Testa, 1970) or to benign bronchial adenomata (Eckert and Seidler, 1971). Even when newborn mice were injected intracerebrally with MNU, only leukaemias and lung tumours, but no brain tumours, resulted (Kelly et al, 1968).…”

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confidence: 99%

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The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice

Searle¹,

Jones²

1976

Br J Cancer

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Summary.-Newborn A, C57BL, DBAf and IF mice were injected s.c. with a range of doses of N-ethyl-N-nitrosourea (ENU). A high proportion of treated mice developed tumours, particularly hepatomata, pulmonary adenomata and carcinomata, and malignant lymphomata of thymus and spleen. Liver tumours occurred most frequently in C57BL and DBAf mice, lung tumours in A mice, and lymphomata in A and DBAf mice. A small proportion of C57BL, DBAf and IF mice developed tumours of the nervous system. The results are discussed with reference to the ready induction of nervous system tumours in similarly treated rats, and their relevance for human cancer.

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Section: Discussionsupporting

confidence: 65%

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confidence: 99%

The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice

Searle¹,

Jones²

1976

Br J Cancer

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“…The incidences of some of these tumours among survivors at 40 weeks of age are reported in Table IV. A significant increase (P < 0.01) of the proportion of mice dying with lung adenomata was found in both sexes in (Graffi and Hoffmann, 1966;Terracini and Stramignoni, 1967;Kelly et al, 1968;Frei, 1970;Joshi and Frei, 1970;Terracini and Testa, 1970;Frei, 1971). The sporadic occurrence of neurogenic tumours in the present series as well as in previous studies differs from findings following a single administration of the related compound N-nitroso-N-ethylurea (Searle and Jones, 1972;Vesselinovitch et al, 1974).…”

Section: Other Tumoursmentioning

confidence: 97%

“…A single adminiAtration of this chemical 'can induice'a high yield of tumours at diff4rent sites in mice and rats (Druckrey et al, 1964;:Graffi and Hoffmann, 1966;-Terracini and Stramignoni, 1967;Kelly et al, 196'';' Leaver, Swann and Magee, 1969-;Frei, 1970;Joshi and Frei, 1970;Terracini arid Testa, 1970;Frei, 1971). NMU-is' also known to undergo rapid deconmposition at physiological pH (Druckrey et 'al., 1967;Swann, 1968 19y?…”

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confidence: 99%

The roles of age at treatment and dose in carcinogenesis in C3Hf/Dp mice with a single administration of N-nitroso-N-methylurea

Terracini¹,

Testa²,

Cabral³

et al. 1976

Br J Cancer

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Summary.-C3Hf/Dp;-mice were given a single i.p. injection of 50, 25 or 5 ,ug/g N-Nitroso-N-Methylurea (NMU) at either I or 70 days of age or 50 flg/g at 21 days of age. They were olbserved until death or until 120 weeks of age.The two highest doses of NMU produced tumours in a wide spectrum of organs, including the thymus, forestomach, lung, liver (only in males), kidneys, ovaries and orbital glands.The only two tumo'lr types which appeared to be closely related to the occurrence of death were thymic lymphomata (most of which were-found in mice dying before 40 weeks after treatment) and carcinomata of the forestomach. Lifetime analyses are presented concerning the occurrence of these two tumour types as well as the occurrence of any tumour'after 40 weeks of age or since treatment.Incidences of thymic lymphomata were 67^60%, 39-0°and 21-20% in mice receiving 50 ,ug/g NMU at 1, 21 and 70 days respectively and 17.1% in mice receiving 25 ug/g at 1 day. In'the other groups the' incidence of thymic lymphomata was zero or negligible. The rate of progression of thymic lymphomata until death was related to both earliness of treatment and dose. On the contrary, incidences and progression of carcinomata of the forestomach were unrelated to age at treatment. Since breakdown of NMU is very rapid and does not require enzymes, these results are considered as evidence that host-tumour interaction differs from organ to organ.No excess of tumours over the controls was found in mice receiving 5 ,ug/g either at 1 or 70 days of age.

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“…On the other hand, thymectomy was precocious enough to prevent any possible interference between the thymus as the major target organ and the extrathymic lymphoid system. NMU has been used because a single dose induces thymic lymphomas with or without involvement of extrathymic organs (Terracini and Stramignoni, 1967).…”

mentioning

confidence: 99%

Nitrosomethylurea-Induced Lymphomas in Thymectomized Mice, in Relation to Thymus-Dependent and Independent Systems

Palestro¹,

Stramignoni²

1975

Oncology

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The present paper describes lymphomagenesis in Swiss mice given nitrosomethylurea (NMU) at birth, and thymectomized at 12 days of age. In mice, at this age, migration of T lymphocytes to other parts of the body has already taken place. On the other hand, the precocious thymectomy prevents any possible interference between thymus and the extrathymic lymphoid system in lymphomagenesis since the major target organ for NMU lymphoma induction is absent. No lymphatic tumours developed in NMU-treated thymectomized mice, although they survived for a long time after thymectomy and about twice as long as the time required for thymus lymphoma production. It can be concluded that NMU in the present experimental system induces lymphomas exclusively in the thymus, while the thymus-dependent and independent areas of the peripheral lymphatic tissues are not affected.

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Malignant lymphomas and renal changes in Swiss mice given nitrosomethylurea

Cited by 16 publications

References 0 publications

The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice

The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice

The roles of age at treatment and dose in carcinogenesis in C3Hf/Dp mice with a single administration of N-nitroso-N-methylurea

Nitrosomethylurea-Induced Lymphomas in Thymectomized Mice, in Relation to Thymus-Dependent and Independent Systems

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